Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis

Bibliographic Details
Main Author: Atta, Ajax Mercês
Publication Date: 1998
Other Authors: D'Oliveira Junior, Argemiro, Correa, Jefferson, Atta, Maria Luiza Brito de Sousa, Almeida, Roque Pacheco de, Carvalho Filho, Edgar Marcelino de
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/12720
Summary: p. 426–430
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spelling Atta, Ajax MercêsD'Oliveira Junior, ArgemiroCorrea, JeffersonAtta, Maria Luiza Brito de SousaAlmeida, Roque Pacheco deCarvalho Filho, Edgar Marcelino deAtta, Ajax MercêsD'Oliveira Junior, ArgemiroCorrea, JeffersonAtta, Maria Luiza Brito de SousaAlmeida, Roque Pacheco deCarvalho Filho, Edgar Marcelino de2013-08-23T21:54:32Z2013-08-23T21:54:32Z1998http://www.repositorio.ufba.br/ri/handle/ri/12720p. 426–430Abstract. Visceral leishmaniasis (VL) is characterized by a depression of the T helper cell type 1 immune response. Although mRNA expression for interleukin-4 (IL-4) is observed, evidence of the role of this cytokine in the pathogenesis of VL has been lacking. Since IL-4 is involved in IgE synthesis, we measured the total IgE and Leishmania antigen-specific IgE antibody levels in sera from patients with VL. Specific IgE antibodies detected by an ELISA technique after absorbing the sera with purified sheep IgG anti-human IgG were found in all 23 patients with VL and were not detected in subjects with subclinical Leishmania chagasi infection (n 5 10), Chagas’ disease (n 5 10), atopic patients (n 5 10), and healthy controls (n 5 10). Levels of Leishmania-specific IgE (optical density values) before and after treatment were 0.100 6 0.03 (mean 6 SD) and 0.028 6 0.002, respectively (P , 0.05). These results indicate that a specific IgE response is useful in the diagnosis of active disease and to evaluate response to treatment.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-08-20T19:04:15Z No. of bitstreams: 1 4444444444444444444444.pdf: 81049 bytes, checksum: 80b46900692f3f8459a653c83f5aca3e (MD5)Approved for entry into archive by Alda Lima da Silva(sivalda@ufba.br) on 2013-08-23T21:54:32Z (GMT) No. of bitstreams: 1 4444444444444444444444.pdf: 81049 bytes, checksum: 80b46900692f3f8459a653c83f5aca3e (MD5)Made available in DSpace on 2013-08-23T21:54:32Z (GMT). No. of bitstreams: 1 4444444444444444444444.pdf: 81049 bytes, checksum: 80b46900692f3f8459a653c83f5aca3e (MD5) Previous issue date: 1998SalvadorThe American Society of Tropical Medicine and Hygienehttp://www.ajtmh.org/content/59/3/426.full.pdf+htmlreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniose visceralAnti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasisThe American Society of Tropical Medicine and Hygieneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12720/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL4444444444444444444444.pdf4444444444444444444444.pdfapplication/pdf81049https://repositorio.ufba.br/bitstream/ri/12720/1/4444444444444444444444.pdf80b46900692f3f8459a653c83f5aca3eMD51TEXT4444444444444444444444.pdf.txt4444444444444444444444.pdf.txtExtracted texttext/plain28039https://repositorio.ufba.br/bitstream/ri/12720/3/4444444444444444444444.pdf.txt3286a0dc0d09eec421debe2bd8c394a4MD53ri/127202022-07-05 14:02:49.941oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:49Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv The American Society of Tropical Medicine and Hygiene
title Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
spellingShingle Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
Atta, Ajax Mercês
Leishmaniose visceral
title_short Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
title_full Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
title_fullStr Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
title_full_unstemmed Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
title_sort Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
author Atta, Ajax Mercês
author_facet Atta, Ajax Mercês
D'Oliveira Junior, Argemiro
Correa, Jefferson
Atta, Maria Luiza Brito de Sousa
Almeida, Roque Pacheco de
Carvalho Filho, Edgar Marcelino de
author_role author
author2 D'Oliveira Junior, Argemiro
Correa, Jefferson
Atta, Maria Luiza Brito de Sousa
Almeida, Roque Pacheco de
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Atta, Ajax Mercês
D'Oliveira Junior, Argemiro
Correa, Jefferson
Atta, Maria Luiza Brito de Sousa
Almeida, Roque Pacheco de
Carvalho Filho, Edgar Marcelino de
Atta, Ajax Mercês
D'Oliveira Junior, Argemiro
Correa, Jefferson
Atta, Maria Luiza Brito de Sousa
Almeida, Roque Pacheco de
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Leishmaniose visceral
topic Leishmaniose visceral
description p. 426–430
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2013-08-23T21:54:32Z
dc.date.available.fl_str_mv 2013-08-23T21:54:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12720
url http://www.repositorio.ufba.br/ri/handle/ri/12720
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv The American Society of Tropical Medicine and Hygiene
dc.source.pt_BR.fl_str_mv http://www.ajtmh.org/content/59/3/426.full.pdf+html
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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