Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16675 |
Resumo: | Texto completo: acesso restrito. p. 2066–2072 |
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Santos, Luciane AmorimCunha, Joana Paixao MonteiroAraujo, Adriano FernandoBrites, CarlosCastro, Bernardo GalvãoAlcântara, Luiz Carlos JúniorSantos, Luciane AmorimCunha, Joana Paixao MonteiroAraujo, Adriano FernandoBrites, CarlosCastro, Bernardo GalvãoAlcântara, Luiz Carlos Júnior2014-11-28T15:45:58Z20110146-6615http://repositorio.ufba.br/ri/handle/ri/16675v. 83, n. 12Texto completo: acesso restrito. p. 2066–2072The extraordinary genetic diversity and immune evasion of human immunodeficiency virus (HIV) pose significant challenges for vaccine development and antiretroviral therapy efficacy. The objective of this study was to characterize the molecular profile of HIV-1 epidemic in Salvador, Bahia, Brazil, determining the genetic subtypes and the presence of antiretroviral resistance mutations. HIV-1 pol DNA sequences from 57 individuals infected with HIV were obtained by PCR, followed by sequencing. The subtypes were determined by phylogenetic analyses and the intersubtype recombination was investigated by bootscanning. The pol subtypes were compared with gag and env subtypes. Antiretroviral susceptibility was evaluated through the Stanford HIV resistance Database. The subtypes frequencies were: 77.2% of subtype B, 1.8% of subtype F1, and 21.0% of BF recombinant forms. Two intergenic and three intragenic BF recombinant patterns were observed. Six (10.5%) viruses were related to CRF28/CRF29, two were related to CRF12 (3.5%), and one (1.8%) was CRF39. Fourteen (24.6%) strains carried one or more mutations associated with at least intermediate resistance: 24.6% had resistance to nucleoside reverse transcriptase inhibitors, 21.0% to non-nucleoside reverse transcriptase inhibitors, and 7% to protease inhibitors. The substitutions I54V (7.0%), M184V (14.0%), and K103N (10.5%) were the most frequent within each class of drugs. The results show a high diversity of BF genotypes and a lower prevalence of major reverse transcriptase and protease drug resistance mutations in Salvador, compared with other regions of Brazil. These findings may contribute to improve treatment strategies of patients infected with HIV-1 from this Brazilian region.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-02-18T14:16:33Z No. of bitstreams: 1 Bernardo Galvao Castro.pdf: 175093 bytes, checksum: 7161dacf3400a63091b7578201e1e0d9 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-28T15:45:58Z (GMT) No. of bitstreams: 1 Bernardo Galvao Castro.pdf: 175093 bytes, checksum: 7161dacf3400a63091b7578201e1e0d9 (MD5)Made available in DSpace on 2014-11-28T15:45:58Z (GMT). No. of bitstreams: 1 Bernardo Galvao Castro.pdf: 175093 bytes, checksum: 7161dacf3400a63091b7578201e1e0d9 (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1002/jmv.22170reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHIV-1CRFResistanceDetection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast BrazilJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALBernardo Galvao Castro.pdfBernardo Galvao Castro.pdfapplication/pdf175093https://repositorio.ufba.br/bitstream/ri/16675/1/Bernardo%20Galvao%20Castro.pdf7161dacf3400a63091b7578201e1e0d9MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16675/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTBernardo Galvao Castro.pdf.txtBernardo Galvao Castro.pdf.txtExtracted texttext/plain27585https://repositorio.ufba.br/bitstream/ri/16675/3/Bernardo%20Galvao%20Castro.pdf.txta362b7ee01812b4ddedfd0f1fee0af6aMD53ri/166752022-07-05 14:02:57.907oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:57Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Journal of Medical Virology |
title |
Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil |
spellingShingle |
Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil Santos, Luciane Amorim HIV-1 CRF Resistance |
title_short |
Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil |
title_full |
Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil |
title_fullStr |
Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil |
title_full_unstemmed |
Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil |
title_sort |
Detection of distinct human immunodeficiency virus Type 1 circulating recombinant forms in Northeast Brazil |
author |
Santos, Luciane Amorim |
author_facet |
Santos, Luciane Amorim Cunha, Joana Paixao Monteiro Araujo, Adriano Fernando Brites, Carlos Castro, Bernardo Galvão Alcântara, Luiz Carlos Júnior |
author_role |
author |
author2 |
Cunha, Joana Paixao Monteiro Araujo, Adriano Fernando Brites, Carlos Castro, Bernardo Galvão Alcântara, Luiz Carlos Júnior |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Luciane Amorim Cunha, Joana Paixao Monteiro Araujo, Adriano Fernando Brites, Carlos Castro, Bernardo Galvão Alcântara, Luiz Carlos Júnior Santos, Luciane Amorim Cunha, Joana Paixao Monteiro Araujo, Adriano Fernando Brites, Carlos Castro, Bernardo Galvão Alcântara, Luiz Carlos Júnior |
dc.subject.por.fl_str_mv |
HIV-1 CRF Resistance |
topic |
HIV-1 CRF Resistance |
description |
Texto completo: acesso restrito. p. 2066–2072 |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2014-11-28T15:45:58Z |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://repositorio.ufba.br/ri/handle/ri/16675 |
dc.identifier.issn.none.fl_str_mv |
0146-6615 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 83, n. 12 |
identifier_str_mv |
0146-6615 v. 83, n. 12 |
url |
http://repositorio.ufba.br/ri/handle/ri/16675 |
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eng |
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eng |
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http://dx.doi.org/ 10.1002/jmv.22170 |
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