Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America

Detalhes bibliográficos
Autor(a) principal: Figueiredo, Camila Alexandrina
Data de Publicação: 2013
Outros Autores: Amorim, Leila Denise Alves Ferreira, Alcântara-Neves, Neuza Maria, Matos, Sheila Maria Alvim de, Cooper, Philip J., Rodrigues, Laura C., Barreto, Mauricio Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/11948
Resumo: Texto completo. Acesso restrito. p. 1064-1068
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spelling Figueiredo, Camila AlexandrinaAmorim, Leila Denise Alves FerreiraAlcântara-Neves, Neuza MariaMatos, Sheila Maria Alvim deCooper, Philip J.Rodrigues, Laura C.Barreto, Mauricio LimaFigueiredo, Camila AlexandrinaAmorim, Leila Denise Alves FerreiraAlcântara-Neves, Neuza MariaMatos, Sheila Maria Alvim deCooper, Philip J.Rodrigues, Laura C.Barreto, Mauricio Lima2013-06-17T13:32:37Z2013-06-17T13:32:37Z20130091-6749http://www.repositorio.ufba.br/ri/handle/ri/11948v. 131, n. 4Texto completo. Acesso restrito. p. 1064-1068Background It has been proposed that improved hygiene and reduced experience of infections in childhood influences the development of allergic diseases. The mechanisms by which the hygiene operates are not well established but are underpinned by two apparently incompatible immunologic paradigms, the balance of TH1 versus TH2 cytokines and IL-10–mediated regulation of TH2 cytokines. Objective This study defined immunologic phenotypes with the use of latent class analysis and investigated their associations with environmental factors, markers of allergy and asthma, in a Latin American population. Methods We studied 1127 children living in urban Brazil. Data on wheeze and environmental exposures were collected with standardized questionnaires. Atopy was measured by specific IgE in serum and skin prick test reactivity to aeroallergens. Cytokines were measured in culture after the stimulation of peripheral blood leukocytes with mitogen. Infections with pathogens were assessed by serology and stool examinations. Children were classified as having high or low burden of infection. Latent class analysis was used to identify immune phenotypes on the basis of cytokine production. Logistic regression was used to evaluate the adjusted effects of environment and burden of infection on the immunologic phenotypes and the effect of the phenotypes on atopy and asthma. Results Three phenotypes were identified, labeled underresponsive, intermediate, and responsive. Children of more educated mothers, living in improved environmental conditions, and with a low burden of infection were significantly more likely to have the responsive phenotype. The responsive phenotype was significantly associated with an increased prevalence of atopy but not asthma. Conclusion Our findings contribute to a better understanding of the immune mechanisms by which the hygiene hypothesis operates in urban Latin America.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-06-17T13:32:37Z No. of bitstreams: 1 22222222222.pdf: 154786 bytes, checksum: 0e61d96490c243a4bed35abd60aa18ea (MD5)Made available in DSpace on 2013-06-17T13:32:37Z (GMT). No. of bitstreams: 1 22222222222.pdf: 154786 bytes, checksum: 0e61d96490c243a4bed35abd60aa18ea (MD5) Previous issue date: 2013SalvadorJournal of Allergy and Clinical Immunologyhttp://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.jaci.2013.01.016reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALCAenvironmentinfectionsimmune phenotypeschildrenhygiene hypothesisSCAALAEnvironmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin AmericaJournal of Allergy and Clinical Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/11948/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL22222222222.pdf22222222222.pdfapplication/pdf154786https://repositorio.ufba.br/bitstream/ri/11948/1/22222222222.pdf0e61d96490c243a4bed35abd60aa18eaMD51TEXT22222222222.pdf.txt22222222222.pdf.txtExtracted texttext/plain33524https://repositorio.ufba.br/bitstream/ri/11948/3/22222222222.pdf.txtf15f97f07f39485aa80a76b13580f63eMD53ri/119482022-07-05 14:02:50.364oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
dc.title.alternative.pt_BR.fl_str_mv Journal of Allergy and Clinical Immunology
title Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
spellingShingle Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
Figueiredo, Camila Alexandrina
LCA
environment
infections
immune phenotypes
children
hygiene hypothesis
SCAALA
title_short Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
title_full Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
title_fullStr Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
title_full_unstemmed Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
title_sort Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
author Figueiredo, Camila Alexandrina
author_facet Figueiredo, Camila Alexandrina
Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
Matos, Sheila Maria Alvim de
Cooper, Philip J.
Rodrigues, Laura C.
Barreto, Mauricio Lima
author_role author
author2 Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
Matos, Sheila Maria Alvim de
Cooper, Philip J.
Rodrigues, Laura C.
Barreto, Mauricio Lima
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo, Camila Alexandrina
Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
Matos, Sheila Maria Alvim de
Cooper, Philip J.
Rodrigues, Laura C.
Barreto, Mauricio Lima
Figueiredo, Camila Alexandrina
Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
Matos, Sheila Maria Alvim de
Cooper, Philip J.
Rodrigues, Laura C.
Barreto, Mauricio Lima
dc.subject.por.fl_str_mv LCA
environment
infections
immune phenotypes
children
hygiene hypothesis
SCAALA
topic LCA
environment
infections
immune phenotypes
children
hygiene hypothesis
SCAALA
description Texto completo. Acesso restrito. p. 1064-1068
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-06-17T13:32:37Z
dc.date.available.fl_str_mv 2013-06-17T13:32:37Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/11948
dc.identifier.issn.none.fl_str_mv 0091-6749
dc.identifier.number.pt_BR.fl_str_mv v. 131, n. 4
identifier_str_mv 0091-6749
v. 131, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/11948
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Journal of Allergy and Clinical Immunology
publisher.none.fl_str_mv Journal of Allergy and Clinical Immunology
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.jaci.2013.01.016
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