Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/11948 |
Resumo: | Texto completo. Acesso restrito. p. 1064-1068 |
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Figueiredo, Camila AlexandrinaAmorim, Leila Denise Alves FerreiraAlcântara-Neves, Neuza MariaMatos, Sheila Maria Alvim deCooper, Philip J.Rodrigues, Laura C.Barreto, Mauricio LimaFigueiredo, Camila AlexandrinaAmorim, Leila Denise Alves FerreiraAlcântara-Neves, Neuza MariaMatos, Sheila Maria Alvim deCooper, Philip J.Rodrigues, Laura C.Barreto, Mauricio Lima2013-06-17T13:32:37Z2013-06-17T13:32:37Z20130091-6749http://www.repositorio.ufba.br/ri/handle/ri/11948v. 131, n. 4Texto completo. Acesso restrito. p. 1064-1068Background It has been proposed that improved hygiene and reduced experience of infections in childhood influences the development of allergic diseases. The mechanisms by which the hygiene operates are not well established but are underpinned by two apparently incompatible immunologic paradigms, the balance of TH1 versus TH2 cytokines and IL-10–mediated regulation of TH2 cytokines. Objective This study defined immunologic phenotypes with the use of latent class analysis and investigated their associations with environmental factors, markers of allergy and asthma, in a Latin American population. Methods We studied 1127 children living in urban Brazil. Data on wheeze and environmental exposures were collected with standardized questionnaires. Atopy was measured by specific IgE in serum and skin prick test reactivity to aeroallergens. Cytokines were measured in culture after the stimulation of peripheral blood leukocytes with mitogen. Infections with pathogens were assessed by serology and stool examinations. Children were classified as having high or low burden of infection. Latent class analysis was used to identify immune phenotypes on the basis of cytokine production. Logistic regression was used to evaluate the adjusted effects of environment and burden of infection on the immunologic phenotypes and the effect of the phenotypes on atopy and asthma. Results Three phenotypes were identified, labeled underresponsive, intermediate, and responsive. Children of more educated mothers, living in improved environmental conditions, and with a low burden of infection were significantly more likely to have the responsive phenotype. The responsive phenotype was significantly associated with an increased prevalence of atopy but not asthma. Conclusion Our findings contribute to a better understanding of the immune mechanisms by which the hygiene hypothesis operates in urban Latin America.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-06-17T13:32:37Z No. of bitstreams: 1 22222222222.pdf: 154786 bytes, checksum: 0e61d96490c243a4bed35abd60aa18ea (MD5)Made available in DSpace on 2013-06-17T13:32:37Z (GMT). No. of bitstreams: 1 22222222222.pdf: 154786 bytes, checksum: 0e61d96490c243a4bed35abd60aa18ea (MD5) Previous issue date: 2013SalvadorJournal of Allergy and Clinical Immunologyhttp://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.jaci.2013.01.016reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALCAenvironmentinfectionsimmune phenotypeschildrenhygiene hypothesisSCAALAEnvironmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin AmericaJournal of Allergy and Clinical Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/11948/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL22222222222.pdf22222222222.pdfapplication/pdf154786https://repositorio.ufba.br/bitstream/ri/11948/1/22222222222.pdf0e61d96490c243a4bed35abd60aa18eaMD51TEXT22222222222.pdf.txt22222222222.pdf.txtExtracted texttext/plain33524https://repositorio.ufba.br/bitstream/ri/11948/3/22222222222.pdf.txtf15f97f07f39485aa80a76b13580f63eMD53ri/119482022-07-05 14:02:50.364oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America |
dc.title.alternative.pt_BR.fl_str_mv |
Journal of Allergy and Clinical Immunology |
title |
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America |
spellingShingle |
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America Figueiredo, Camila Alexandrina LCA environment infections immune phenotypes children hygiene hypothesis SCAALA |
title_short |
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America |
title_full |
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America |
title_fullStr |
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America |
title_full_unstemmed |
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America |
title_sort |
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America |
author |
Figueiredo, Camila Alexandrina |
author_facet |
Figueiredo, Camila Alexandrina Amorim, Leila Denise Alves Ferreira Alcântara-Neves, Neuza Maria Matos, Sheila Maria Alvim de Cooper, Philip J. Rodrigues, Laura C. Barreto, Mauricio Lima |
author_role |
author |
author2 |
Amorim, Leila Denise Alves Ferreira Alcântara-Neves, Neuza Maria Matos, Sheila Maria Alvim de Cooper, Philip J. Rodrigues, Laura C. Barreto, Mauricio Lima |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Figueiredo, Camila Alexandrina Amorim, Leila Denise Alves Ferreira Alcântara-Neves, Neuza Maria Matos, Sheila Maria Alvim de Cooper, Philip J. Rodrigues, Laura C. Barreto, Mauricio Lima Figueiredo, Camila Alexandrina Amorim, Leila Denise Alves Ferreira Alcântara-Neves, Neuza Maria Matos, Sheila Maria Alvim de Cooper, Philip J. Rodrigues, Laura C. Barreto, Mauricio Lima |
dc.subject.por.fl_str_mv |
LCA environment infections immune phenotypes children hygiene hypothesis SCAALA |
topic |
LCA environment infections immune phenotypes children hygiene hypothesis SCAALA |
description |
Texto completo. Acesso restrito. p. 1064-1068 |
publishDate |
2013 |
dc.date.accessioned.fl_str_mv |
2013-06-17T13:32:37Z |
dc.date.available.fl_str_mv |
2013-06-17T13:32:37Z |
dc.date.issued.fl_str_mv |
2013 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/11948 |
dc.identifier.issn.none.fl_str_mv |
0091-6749 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 131, n. 4 |
identifier_str_mv |
0091-6749 v. 131, n. 4 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/11948 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Journal of Allergy and Clinical Immunology |
publisher.none.fl_str_mv |
Journal of Allergy and Clinical Immunology |
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http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.jaci.2013.01.016 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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