Primary focal segmental glomerulosclerosis in children: prognostic factors

Detalhes bibliográficos
Autor(a) principal: Martinelli, Reinaldo
Data de Publicação: 2001
Outros Autores: Okumura, Alice Setsuko, Pereira, Luis José, Rocha, Heonir
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7703
Resumo: Texto completo: acesso restrito. p. 658–661
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spelling Martinelli, ReinaldoOkumura, Alice SetsukoPereira, Luis JoséRocha, HeonirMartinelli, ReinaldoOkumura, Alice SetsukoPereira, Luis JoséRocha, Heonir2012-12-20T18:59:24Z20010931-041Xhttp://www.repositorio.ufba.br/ri/handle/ri/7703v. 16, n. 8Texto completo: acesso restrito. p. 658–661To study the clinical course and the predictors of outcome in children and adolescents, 39 patients with nephrotic syndrome and primary focal segmental glomerulosclerosis (FSGS) were followed for a mean of 84.6 months. Thirty-six patients were treated with prednisone, either alone or in conjunction with cyclophosphamide. The clinical course was one of sustained remission in 4 patients, frequent relapse in 13, persistent nonnephrotic proteinuria in 5, and persistent nephrotic syndrome in 17; 2 patients had stable renal failure and 8 had progressive renal failure, 5 of them evolving to end-stage renal failure (ESRF). Resistance to prednisone was recorded in 76.6% of patients. The use of cyclophosphamide plus prednisone was of benefit in 42.8% of patients; 22.2% of the prednisone-resistant patients achieved remission of the nephrotic syndrome. A Kaplan-Meier analysis revealed a survival rate of 92% after 5 years, 86% after 10 years, and 76% after 15 years. Using both univariate and multivariate analysis, persistent nephrotic syndrome was associated with progression to ESRF and the remission of proteinuria with maintenance of renal function. As the outcome of the nephrotic syndrome in FSGS is significantly improved by remission of proteinuria, it is conceivable that immunosuppressive medication may be used in conjunction with prednisone in patients with steroid resistance.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-20T18:59:24Z No. of bitstreams: 1 Martinelli.pdf: 159351 bytes, checksum: b287502dc1350eaae5baa4ee8f227dd6 (MD5)Made available in DSpace on 2012-12-20T18:59:24Z (GMT). No. of bitstreams: 1 Martinelli.pdf: 159351 bytes, checksum: b287502dc1350eaae5baa4ee8f227dd6 (MD5) Previous issue date: 2001http://dx.doi.org/10.1007/s004670100639reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANephrotic syndromeFocal segmental glomerulosclerosisPredictorsCyclophosphamideOutcomePrimary focal segmental glomerulosclerosis in children: prognostic factorsPediatric Nephrologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7703/3/license.txt1b89a9a0548218172d7c829f87a0eab9MD53ORIGINALMartinelli.pdfMartinelli.pdfapplication/pdf159351https://repositorio.ufba.br/bitstream/ri/7703/1/Martinelli.pdfb287502dc1350eaae5baa4ee8f227dd6MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7703/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTMartinelli.pdf.txtMartinelli.pdf.txtExtracted texttext/plain22287https://repositorio.ufba.br/bitstream/ri/7703/4/Martinelli.pdf.txtd6b2a5532006147f2050b270c1562c2cMD54ri/77032022-07-05 14:03:08.882oai:repositorio.ufba.br:ri/7703Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:08Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Primary focal segmental glomerulosclerosis in children: prognostic factors
dc.title.alternative.pt_BR.fl_str_mv Pediatric Nephrology
title Primary focal segmental glomerulosclerosis in children: prognostic factors
spellingShingle Primary focal segmental glomerulosclerosis in children: prognostic factors
Martinelli, Reinaldo
Nephrotic syndrome
Focal segmental glomerulosclerosis
Predictors
Cyclophosphamide
Outcome
title_short Primary focal segmental glomerulosclerosis in children: prognostic factors
title_full Primary focal segmental glomerulosclerosis in children: prognostic factors
title_fullStr Primary focal segmental glomerulosclerosis in children: prognostic factors
title_full_unstemmed Primary focal segmental glomerulosclerosis in children: prognostic factors
title_sort Primary focal segmental glomerulosclerosis in children: prognostic factors
author Martinelli, Reinaldo
author_facet Martinelli, Reinaldo
Okumura, Alice Setsuko
Pereira, Luis José
Rocha, Heonir
author_role author
author2 Okumura, Alice Setsuko
Pereira, Luis José
Rocha, Heonir
author2_role author
author
author
dc.contributor.author.fl_str_mv Martinelli, Reinaldo
Okumura, Alice Setsuko
Pereira, Luis José
Rocha, Heonir
Martinelli, Reinaldo
Okumura, Alice Setsuko
Pereira, Luis José
Rocha, Heonir
dc.subject.por.fl_str_mv Nephrotic syndrome
Focal segmental glomerulosclerosis
Predictors
Cyclophosphamide
Outcome
topic Nephrotic syndrome
Focal segmental glomerulosclerosis
Predictors
Cyclophosphamide
Outcome
description Texto completo: acesso restrito. p. 658–661
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2012-12-20T18:59:24Z
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7703
dc.identifier.issn.none.fl_str_mv 0931-041X
dc.identifier.number.pt_BR.fl_str_mv v. 16, n. 8
identifier_str_mv 0931-041X
v. 16, n. 8
url http://www.repositorio.ufba.br/ri/handle/ri/7703
dc.language.iso.fl_str_mv eng
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