Helminthic infection and the risk of neurologic disease progression in HTLV-1

Detalhes bibliográficos
Autor(a) principal: Sundberg, Michael A.
Data de Publicação: 2012
Outros Autores: Costa, Davi, Orge, Gloria, Castro, Néviton Matos de, Muniz, André Luís Nunes, Glesby, Marshall J., Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16145
Resumo: Texto completo: acesso restrito. p. 251–255
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spelling Sundberg, Michael A.Costa, DaviOrge, GloriaCastro, Néviton Matos deMuniz, André Luís NunesGlesby, Marshall J.Carvalho Filho, Edgar Marcelino deSundberg, Michael A.Costa, DaviOrge, GloriaCastro, Néviton Matos deMuniz, André Luís NunesGlesby, Marshall J.Carvalho Filho, Edgar Marcelino de2014-09-23T13:56:37Z20121386-6532http://repositorio.ufba.br/ri/handle/ri/16145v. 53, n. 3Texto completo: acesso restrito. p. 251–255Background Infection with the human T-cell lymphotropic virus, type 1 (HTLV-1) has been associated with an increased Th1 response. Interestingly, a higher prevalence of helminthic coinfection has been observed among infected individuals, and subsequent modulation of the immune response typically associated with helminths may influence clinical outcomes among HTLV-1 coinfected individuals. Objective This study was conducted to elucidate the association between helminthic coinfection and the development of clinically characterized neurologic disease that occurs in HTLV-1 infection. Study design In a cohort analysis, incidence of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was recorded. Incidence of clinical outcomes and disease-free survival of several neurologic outcomes associated with HTLV-1 were estimated using the Kaplan–Meier method with log-rank tests. The relationships between helminthic infection and risk of HTLV-1 neurologic outcomes were assessed by Cox proportional hazard modeling. Results Seventy-four coinfected and 79 non-coinfected patients were followed, with 92 helminthic infections observed in the coinfected group. One patient per group developed HAM/TSP and the risk of progression to neurologic disease outcomes did not differ among those with and without helminthic coinfection (p > 0.45). A significant difference was noted in the prevalence of neurologic disease outcomes among all patients at the conclusion of the study (p < 0.01). Conclusions These data suggest that treated helminthic infection does not affect risk of development of neurologic disease in HTLV-1 infection, and reinforce that treatment of helminths does not adversely affect patients with HTLV-1. Importantly, among all patients, an overall progression of neurologic disease was observed.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-20T12:51:08Z No. of bitstreams: 1 Michael A. Sundberg.pdf: 479242 bytes, checksum: ee5a057bf24da81885b61f169cba42fb (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-09-23T13:56:37Z (GMT) No. of bitstreams: 1 Michael A. Sundberg.pdf: 479242 bytes, checksum: ee5a057bf24da81885b61f169cba42fb (MD5)Made available in DSpace on 2014-09-23T13:56:37Z (GMT). No. of bitstreams: 1 Michael A. Sundberg.pdf: 479242 bytes, checksum: ee5a057bf24da81885b61f169cba42fb (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1016/j.jcv.2011.12.018reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHTLV-1HAM/TSPNeurologic diseaseHelminthsSurvival analysisHelminthic infection and the risk of neurologic disease progression in HTLV-1Journal of Clinical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16145/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52ORIGINALMichael A. Sundberg.pdfMichael A. Sundberg.pdfapplication/pdf479242https://repositorio.ufba.br/bitstream/ri/16145/1/Michael%20A.%20Sundberg.pdfee5a057bf24da81885b61f169cba42fbMD51TEXTMichael A. Sundberg.pdf.txtMichael A. 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dc.title.pt_BR.fl_str_mv Helminthic infection and the risk of neurologic disease progression in HTLV-1
dc.title.alternative.pt_BR.fl_str_mv Journal of Clinical Virology
title Helminthic infection and the risk of neurologic disease progression in HTLV-1
spellingShingle Helminthic infection and the risk of neurologic disease progression in HTLV-1
Sundberg, Michael A.
HTLV-1
HAM/TSP
Neurologic disease
Helminths
Survival analysis
title_short Helminthic infection and the risk of neurologic disease progression in HTLV-1
title_full Helminthic infection and the risk of neurologic disease progression in HTLV-1
title_fullStr Helminthic infection and the risk of neurologic disease progression in HTLV-1
title_full_unstemmed Helminthic infection and the risk of neurologic disease progression in HTLV-1
title_sort Helminthic infection and the risk of neurologic disease progression in HTLV-1
author Sundberg, Michael A.
author_facet Sundberg, Michael A.
Costa, Davi
Orge, Gloria
Castro, Néviton Matos de
Muniz, André Luís Nunes
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Costa, Davi
Orge, Gloria
Castro, Néviton Matos de
Muniz, André Luís Nunes
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sundberg, Michael A.
Costa, Davi
Orge, Gloria
Castro, Néviton Matos de
Muniz, André Luís Nunes
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
Sundberg, Michael A.
Costa, Davi
Orge, Gloria
Castro, Néviton Matos de
Muniz, André Luís Nunes
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv HTLV-1
HAM/TSP
Neurologic disease
Helminths
Survival analysis
topic HTLV-1
HAM/TSP
Neurologic disease
Helminths
Survival analysis
description Texto completo: acesso restrito. p. 251–255
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-09-23T13:56:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16145
dc.identifier.issn.none.fl_str_mv 1386-6532
dc.identifier.number.pt_BR.fl_str_mv v. 53, n. 3
identifier_str_mv 1386-6532
v. 53, n. 3
url http://repositorio.ufba.br/ri/handle/ri/16145
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1016/j.jcv.2011.12.018
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