Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14902 |
Resumo: | p. 1-6 |
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Carvalho Filho, Paulo Cirino deTrindade, Soraya CastroOlczak, TeresaSampaio, Geraldo P.Oliveira Neto, Milton G.Santos, Heidiane Alves dosPereira, Bianca F. P.Costa, Lilia MouraXavier, Márcia TostaNascimento, Roberto José MeyerCarvalho Filho, Paulo Cirino deTrindade, Soraya CastroOlczak, TeresaSampaio, Geraldo P.Oliveira Neto, Milton G.Santos, Heidiane Alves dosPereira, Bianca F. P.Costa, Lilia MouraXavier, Márcia TostaNascimento, Roberto José Meyer2014-05-05T13:41:28Z2014-05-05T13:41:28Z20131471-2180http://repositorio.ufba.br/ri/handle/ri/14902v. 13, n. 1p. 1-6Background: Apoptosis is a highly controlled process of cell death that can be induced by periodontopathogens. The present study aimed to investigate the expression of Fas and Bcl-2 proteins by CD3+ T cells in vitro under stimulation by total Porphyromonas gingivalis antigens and purified recombinant P. gingivalis HmuY protein. Results: CD3+ T cells derived from CP patients and stimulated with HmuY expressed higher levels of Bcl-2 compared to identical cells stimulated with P. gingivalis crude extract or cells derived from NP control subjects (p = 0.043). Conclusion: The authors hypothesize that P. gingivalis HmuY plays a role in the pathogenesis of chronic periodontitis, possibly by reducing or delaying apoptosis in T cells through a pathway involving the Bcl-2 protein.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-05T13:41:28Z No. of bitstreams: 1 1471-2180-13-206.pdf: 352627 bytes, checksum: 4dc8ffb5e345d260f7a3e95deca4758a (MD5)Made available in DSpace on 2014-05-05T13:41:28Z (GMT). No. of bitstreams: 1 1471-2180-13-206.pdf: 352627 bytes, checksum: 4dc8ffb5e345d260f7a3e95deca4758a (MD5) Previous issue date: 2013http://dx.doi.org/10.1186/1471-2180-13-206reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAPorphyromonas gingivalisHmuYBcl-2FasApoptosisPorphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cellsBMC Microbiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINAL1471-2180-13-206.pdf1471-2180-13-206.pdfapplication/pdf352627https://repositorio.ufba.br/bitstream/ri/14902/1/1471-2180-13-206.pdf4dc8ffb5e345d260f7a3e95deca4758aMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14902/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT1471-2180-13-206.pdf.txt1471-2180-13-206.pdf.txtExtracted texttext/plain29439https://repositorio.ufba.br/bitstream/ri/14902/3/1471-2180-13-206.pdf.txt5a68d602ef0668b2418e8a4784f49f3cMD53ri/149022022-08-08 13:17:42.481oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:42Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells |
| dc.title.alternative.pt_BR.fl_str_mv |
BMC Microbiology |
| title |
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells |
| spellingShingle |
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells Carvalho Filho, Paulo Cirino de Porphyromonas gingivalis HmuY Bcl-2 Fas Apoptosis |
| title_short |
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells |
| title_full |
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells |
| title_fullStr |
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells |
| title_full_unstemmed |
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells |
| title_sort |
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells |
| author |
Carvalho Filho, Paulo Cirino de |
| author_facet |
Carvalho Filho, Paulo Cirino de Trindade, Soraya Castro Olczak, Teresa Sampaio, Geraldo P. Oliveira Neto, Milton G. Santos, Heidiane Alves dos Pereira, Bianca F. P. Costa, Lilia Moura Xavier, Márcia Tosta Nascimento, Roberto José Meyer |
| author_role |
author |
| author2 |
Trindade, Soraya Castro Olczak, Teresa Sampaio, Geraldo P. Oliveira Neto, Milton G. Santos, Heidiane Alves dos Pereira, Bianca F. P. Costa, Lilia Moura Xavier, Márcia Tosta Nascimento, Roberto José Meyer |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho Filho, Paulo Cirino de Trindade, Soraya Castro Olczak, Teresa Sampaio, Geraldo P. Oliveira Neto, Milton G. Santos, Heidiane Alves dos Pereira, Bianca F. P. Costa, Lilia Moura Xavier, Márcia Tosta Nascimento, Roberto José Meyer Carvalho Filho, Paulo Cirino de Trindade, Soraya Castro Olczak, Teresa Sampaio, Geraldo P. Oliveira Neto, Milton G. Santos, Heidiane Alves dos Pereira, Bianca F. P. Costa, Lilia Moura Xavier, Márcia Tosta Nascimento, Roberto José Meyer |
| dc.subject.por.fl_str_mv |
Porphyromonas gingivalis HmuY Bcl-2 Fas Apoptosis |
| topic |
Porphyromonas gingivalis HmuY Bcl-2 Fas Apoptosis |
| description |
p. 1-6 |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
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2014-05-05T13:41:28Z |
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2014-05-05T13:41:28Z |
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info:eu-repo/semantics/article |
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1471-2180 |
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v. 13, n. 1 |
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1471-2180 v. 13, n. 1 |
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http://repositorio.ufba.br/ri/handle/ri/14902 |
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http://dx.doi.org/10.1186/1471-2180-13-206 |
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