Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance

Detalhes bibliográficos
Autor(a) principal: Andrade, Bruno Bezerril
Data de Publicação: 2010
Outros Autores: Reis Filho, Antonio, Souza Neto, Sebastião Martins, Clarêncio, Jorge, Camargo, Luís Marcelo Aranha, Barral, Aldina Maria Prado, Barral-Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6063
Resumo: p. 1-8
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spelling Andrade, Bruno BezerrilReis Filho, AntonioSouza Neto, Sebastião MartinsClarêncio, JorgeCamargo, Luís Marcelo AranhaBarral, Aldina Maria PradoBarral-Netto, ManoelAndrade, Bruno BezerrilReis Filho, AntonioSouza Neto, Sebastião MartinsClarêncio, JorgeCamargo, Luís Marcelo AranhaBarral, Aldina Maria PradoBarral-Netto, Manoel2012-06-04T18:11:18Z2012-06-04T18:11:18Z20101475-2875http://www.repositorio.ufba.br/ri/handle/ri/6063v. 9, n. 13p. 1-8Background: Despite clinical descriptions of severe vivax malaria cases having been reported, data regarding immunological and inflammatory patterns are scarce. In this report, the inflammatory and immunological status of both mild and severe vivax malaria cases are compared in order to explore immunopathological events in this disease. Methods and Results: Active and passive malaria case detections were performed during 2007 in Buritis, Rondônia, in the Brazilian Amazon. A total of 219 participants enrolled the study. Study individuals were classified according to the presence of Plasmodium vivax infection within four groups: non-infected (n = 90), asymptomatic (n = 60), mild (n = 50) and severe vivax infection (n = 19). A diagnosis of malaria was made by microscopy and molecular assays. Since at present no clear criteria define severe vivax malaria, this study adapted the consensual criteria from falciparum malaria. Patients with severe P. vivax infection were younger, had lived for shorter time in the endemic area, and recalled having experienced less previous malaria episodes than individuals with no malaria infection and with mild or asymptomatic infection. Strong linear trends were identified regarding increasing plasma levels of C reactive protein (CRP), serum creatinine, bilirubins and the graduation of disease severity. Plasma levels of tumour necrosis factor (TNF), interferon-gamma(IFN-gamma) and also IFN-gamma/interleukin-10 ratios were increased and exhibited a linear trend with gradual augmentation of disease severity. Both laboratory parameters of organ dysfunction and inflammatory cytokines were reduced during anti-parasite therapy in those patients with severe disease. Conclusion: Different clinical presentations of vivax malaria infection present strong association with activation of pro-inflammatory responses and cytokine imbalance. These findings are of utmost importance to improve current knowledge about physiopathological concepts of this serious widespread disease.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-06-04T18:11:18Z No. of bitstreams: 1 (53)1475-2875-9-13.pdf: 686525 bytes, checksum: c7f261ecc134e7e4ae02d8ad8d880c29 (MD5)Made available in DSpace on 2012-06-04T18:11:18Z (GMT). No. of bitstreams: 1 (53)1475-2875-9-13.pdf: 686525 bytes, checksum: c7f261ecc134e7e4ae02d8ad8d880c29 (MD5) Previous issue date: 2010BioMed10.1186/1475-2875-9-13reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASevere Plasmodium vivax malaria exhibits marked inflammatory imbalanceMalaria Journalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6063/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL(53)1475-2875-9-13.pdf(53)1475-2875-9-13.pdfapplication/pdf686525https://repositorio.ufba.br/bitstream/ri/6063/1/%2853%291475-2875-9-13.pdfc7f261ecc134e7e4ae02d8ad8d880c29MD51TEXT(53)1475-2875-9-13.pdf.txt(53)1475-2875-9-13.pdf.txtExtracted texttext/plain32519https://repositorio.ufba.br/bitstream/ri/6063/3/%2853%291475-2875-9-13.pdf.txtd132f06eb877a38b8467b170c62a27c6MD53ri/60632022-07-05 14:03:21.253oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
dc.title.alternative.pt_BR.fl_str_mv Malaria Journal
title Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
spellingShingle Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
Andrade, Bruno Bezerril
title_short Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
title_full Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
title_fullStr Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
title_full_unstemmed Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
title_sort Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
author Andrade, Bruno Bezerril
author_facet Andrade, Bruno Bezerril
Reis Filho, Antonio
Souza Neto, Sebastião Martins
Clarêncio, Jorge
Camargo, Luís Marcelo Aranha
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author_role author
author2 Reis Filho, Antonio
Souza Neto, Sebastião Martins
Clarêncio, Jorge
Camargo, Luís Marcelo Aranha
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Bruno Bezerril
Reis Filho, Antonio
Souza Neto, Sebastião Martins
Clarêncio, Jorge
Camargo, Luís Marcelo Aranha
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Andrade, Bruno Bezerril
Reis Filho, Antonio
Souza Neto, Sebastião Martins
Clarêncio, Jorge
Camargo, Luís Marcelo Aranha
Barral, Aldina Maria Prado
Barral-Netto, Manoel
description p. 1-8
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-06-04T18:11:18Z
dc.date.available.fl_str_mv 2012-06-04T18:11:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6063
dc.identifier.issn.none.fl_str_mv 1475-2875
dc.identifier.number.pt_BR.fl_str_mv v. 9, n. 13
identifier_str_mv 1475-2875
v. 9, n. 13
url http://www.repositorio.ufba.br/ri/handle/ri/6063
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv BioMed
publisher.none.fl_str_mv BioMed
dc.source.pt_BR.fl_str_mv 10.1186/1475-2875-9-13
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