Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies

Detalhes bibliográficos
Autor(a) principal: Athanazio, Daniel Abensur
Data de Publicação: 2009
Outros Autores: Sweet, Gloria Maria Maranhão, Silva, Carlos Alberto, Santos, Washington Luis Conrado dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/4783
Resumo: p.643–651
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spelling Athanazio, Daniel AbensurSweet, Gloria Maria MaranhãoSilva, Carlos AlbertoSantos, Washington Luis Conrado dosAthanazio, Daniel AbensurSweet, Gloria Maria MaranhãoSilva, Carlos AlbertoSantos, Washington Luis Conrado dos2011-12-06T13:45:53Z2011-12-06T13:45:53Z20091573-2584http://www.repositorio.ufba.br/ri/handle/ri/4783n. 41p.643–651Chronic lesions in renal biopsies are a well recognized prognostic factor for renal diseases, including lupus nephritis. The methods used for assessment of chronic lesions are, however, largely based on semiquantitative evaluation and may lead to poor reproducibility. Interobserver variation is particularly important in lupus nephritis, in which acute and chronic lesions may occur simultaneously. In this study we tested the reproducibility of chronic lesion assessment performed by three pathologists, two with specific training in renal pathology, using 20 renal biopsies and a standard semiquantitative method. In a second experiment, we evaluated the reproducibility of chronic lesion assessment in 33 biopsies of lupus nephritis by the two nephropathologists. The semiquantitative estimated values were compared with those from a previously proposed morphometric method for quantification of chronic lesions in renal biopsies. Although correlations were observed among the estimated values, there was a wide range of variation when semiquantitative methods were used. In particular, activity and chronicity indices of lupus nephritis were poorly reproducible. In contrast, use of a morphometric score, although not eliminating interobserver variability, led to better reproducibility of estimated values than that obtained with semiquantitative methods.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-12-06T13:45:53Z No. of bitstreams: 1 text.pdf: 272388 bytes, checksum: a3b28236816aaca079e186e45391bb01 (MD5)Made available in DSpace on 2011-12-06T13:45:53Z (GMT). No. of bitstreams: 1 text.pdf: 272388 bytes, checksum: a3b28236816aaca079e186e45391bb01 (MD5) Previous issue date: 2009Lupus nephritisKidneyRenal biopsyReproducibility of resultsInterstitial fibrosisSemiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsiesInternational Urology and Nephrologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALtext.pdftext.pdfapplication/pdf272388https://repositorio.ufba.br/bitstream/ri/4783/1/text.pdfa3b28236816aaca079e186e45391bb01MD51LICENSElicense.txtlicense.txttext/plain1748https://repositorio.ufba.br/bitstream/ri/4783/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTtext.pdf.txttext.pdf.txtExtracted texttext/plain33136https://repositorio.ufba.br/bitstream/ri/4783/3/text.pdf.txt4230c372dc50df9b71f65779f4ec65d1MD53ri/47832022-07-05 14:03:16.899oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:16Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
dc.title.alternative.pt_BR.fl_str_mv International Urology and Nephrology
title Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
spellingShingle Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
Athanazio, Daniel Abensur
Lupus nephritis
Kidney
Renal biopsy
Reproducibility of results
Interstitial fibrosis
title_short Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title_full Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title_fullStr Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title_full_unstemmed Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title_sort Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
author Athanazio, Daniel Abensur
author_facet Athanazio, Daniel Abensur
Sweet, Gloria Maria Maranhão
Silva, Carlos Alberto
Santos, Washington Luis Conrado dos
author_role author
author2 Sweet, Gloria Maria Maranhão
Silva, Carlos Alberto
Santos, Washington Luis Conrado dos
author2_role author
author
author
dc.contributor.author.fl_str_mv Athanazio, Daniel Abensur
Sweet, Gloria Maria Maranhão
Silva, Carlos Alberto
Santos, Washington Luis Conrado dos
Athanazio, Daniel Abensur
Sweet, Gloria Maria Maranhão
Silva, Carlos Alberto
Santos, Washington Luis Conrado dos
dc.subject.por.fl_str_mv Lupus nephritis
Kidney
Renal biopsy
Reproducibility of results
Interstitial fibrosis
topic Lupus nephritis
Kidney
Renal biopsy
Reproducibility of results
Interstitial fibrosis
description p.643–651
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-12-06T13:45:53Z
dc.date.available.fl_str_mv 2011-12-06T13:45:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/4783
dc.identifier.issn.none.fl_str_mv 1573-2584
dc.identifier.number.pt_BR.fl_str_mv n. 41
identifier_str_mv 1573-2584
n. 41
url http://www.repositorio.ufba.br/ri/handle/ri/4783
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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