Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies

Detalhes bibliográficos
Autor(a) principal: Athanazio, Daniel Abensur
Data de Publicação: 2009
Outros Autores: Sweet, Gloria Maria Maranhão, Silva, Carlos Alberto, dosSantos, Washington Luis Conrado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14017
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Athanazio, Daniel AbensurSweet, Gloria Maria MaranhãoSilva, Carlos AlbertodosSantos, Washington Luis Conrado2016-04-28T16:44:26Z2016-04-28T16:44:26Z2009ATHANAZIO, D. A. et al. Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies. International Urology Nephrology, v. 41, n. 3, p. 643-645, 2009.1573-2584https://www.arca.fiocruz.br/handle/icict/1401710.1007/s11255-008-9494-9engSpringer VerlagSemiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilChronic lesions in renal biopsies are a well recognized prognostic factor for renal diseases, including lupus nephritis. The methods used for assessment of chronic lesions are, however, largely based on semiquantitative evaluation and may lead to poor reproducibility. Interobserver variation is particularly important in lupus nephritis, in which acute and chronic lesions may occur simultaneously. In this study we tested the reproducibility of chronic lesion assessment performed by three pathologists, two with specific training in renal pathology, using 20 renal biopsies and a standard semiquantitative method. In a second experiment, we evaluated the reproducibility of chronic lesion assessment in 33 biopsies of lupus nephritis by the two nephropathologists. The semiquantitative estimated values were compared with those from a previously proposed morphometric method for quantification of chronic lesions in renal biopsies. Although correlations were observed among the estimated values, there was a wide range of variation when semiquantitative methods were used. In particular, activity and chronicity indices of lupus nephritis were poorly reproducible. In contrast, use of a morphometric score, although not eliminating interobserver variability, led to better reproducibility of estimated values than that obtained with semiquantitative methods.Lupus nephritisKidneyRenal biopsyReproducibility of resultsInterstitial fibrosisNefropatias/patologiaRim/patologiaBiópsia/métodosBiópsia/estatística & dados numéricosDoença CrônicaHumanosNefrite Lúpica/patologiaVariações Dependentes do ObservadorReprodutibilidade dos Testesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14017/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAthanazio DA Semiquantitative....pdfAthanazio DA 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dc.title.pt_BR.fl_str_mv Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
spellingShingle Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
Athanazio, Daniel Abensur
Lupus nephritis
Kidney
Renal biopsy
Reproducibility of results
Interstitial fibrosis
Nefropatias/patologia
Rim/patologia
Biópsia/métodos
Biópsia/estatística & dados numéricos
Doença Crônica
Humanos
Nefrite Lúpica/patologia
Variações Dependentes do Observador
Reprodutibilidade dos Testes
title_short Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title_full Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title_fullStr Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title_full_unstemmed Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
title_sort Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies
author Athanazio, Daniel Abensur
author_facet Athanazio, Daniel Abensur
Sweet, Gloria Maria Maranhão
Silva, Carlos Alberto
dosSantos, Washington Luis Conrado
author_role author
author2 Sweet, Gloria Maria Maranhão
Silva, Carlos Alberto
dosSantos, Washington Luis Conrado
author2_role author
author
author
dc.contributor.author.fl_str_mv Athanazio, Daniel Abensur
Sweet, Gloria Maria Maranhão
Silva, Carlos Alberto
dosSantos, Washington Luis Conrado
dc.subject.en.pt_BR.fl_str_mv Lupus nephritis
Kidney
Renal biopsy
Reproducibility of results
Interstitial fibrosis
topic Lupus nephritis
Kidney
Renal biopsy
Reproducibility of results
Interstitial fibrosis
Nefropatias/patologia
Rim/patologia
Biópsia/métodos
Biópsia/estatística & dados numéricos
Doença Crônica
Humanos
Nefrite Lúpica/patologia
Variações Dependentes do Observador
Reprodutibilidade dos Testes
dc.subject.decs.pt_BR.fl_str_mv Nefropatias/patologia
Rim/patologia
Biópsia/métodos
Biópsia/estatística & dados numéricos
Doença Crônica
Humanos
Nefrite Lúpica/patologia
Variações Dependentes do Observador
Reprodutibilidade dos Testes
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2016-04-28T16:44:26Z
dc.date.available.fl_str_mv 2016-04-28T16:44:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ATHANAZIO, D. A. et al. Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies. International Urology Nephrology, v. 41, n. 3, p. 643-645, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14017
dc.identifier.issn.none.fl_str_mv 1573-2584
dc.identifier.doi.none.fl_str_mv 10.1007/s11255-008-9494-9
identifier_str_mv ATHANAZIO, D. A. et al. Semiquantitative and semi-automated morphometric evaluation of chronic lesions in renal biopsies. International Urology Nephrology, v. 41, n. 3, p. 643-645, 2009.
1573-2584
10.1007/s11255-008-9494-9
url https://www.arca.fiocruz.br/handle/icict/14017
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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