Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Faria, D. R.
Data de Publicação: 2009
Outros Autores: Souza, P. E. A., Durães, F. V., Carvalho Filho, Edgar Marcelino de, Gollob, K. J., Machado, Paulo Roberto Lima, Dutra, Walderez Ornelas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6383
Resumo: Trabalho completo: acesso restrito, p.432–439
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spelling Faria, D. R.Souza, P. E. A.Durães, F. V.Carvalho Filho, Edgar Marcelino deGollob, K. J.Machado, Paulo Roberto LimaDutra, Walderez OrnelasFaria, D. R.Souza, P. E. A.Durães, F. V.Carvalho Filho, Edgar Marcelino deGollob, K. J.Machado, Paulo Roberto LimaDutra, Walderez Ornelas2012-07-09T19:48:10Z20090141-9838http://www.repositorio.ufba.br/ri/handle/ri/6383v. 31, n. 8Trabalho completo: acesso restrito, p.432–439Human infection with Leishmania braziliensis leads to the establishment of cutaneous leishmaniasis (CL), characterized by the appearance of skin lesions that progress from nonulcerated to ulcerated forms. Our goal was to characterize the immunological kinetics associated with this progression, comparing the cellular composition, cytokines and granzyme expression between lesions of patients with early (E-CL) and late stages (L-CL) of CL. Histopathological analysis showed that lesions from L-CL had more exuberant inflammatory infiltrate as compared to E-CL. Although E-CL and L-CL lesions were predominantly mononuclear, lesions from E-CL patients presented higher neutrophil and eosinophil counts than L-CL. While percentages of CD4+ and of CD68+ cells were slightly higher in L-CL, a fivefold increase of CD8+ cells was observed in L-CL, as compared to E-CL. Moreover, CD8+ T-cells from L-CL expressed significantly higher levels of granzyme A than E-CL. Interestingly, granzyme A expression was positively correlated with intensity of the inflammatory infiltrate in L-CL but not E-CL. Lastly, percentages of IFN-c+ and IL-10+ cells were higher in L-CL as compared to E-CL, with CD4+ T-cells and CD68+ monocytes as the main sources of these cytokines, respectively. These results suggest that recruitment of CD8+ granzyme A+ T cells is involved in lesion progression in human CL.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-07-09T19:48:10Z No. of bitstreams: 1 (113)j.1365-3024.2009.01125.x.pdf: 300994 bytes, checksum: 14e5c5ab10f4bab17e0b49fbfcd58826 (MD5)Made available in DSpace on 2012-07-09T19:48:10Z (GMT). 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dc.title.pt_BR.fl_str_mv Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Parasite Immunology
title Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
spellingShingle Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
Faria, D. R.
CD8+ T cells
granzyme
leishmaniasis
lesion
progression
title_short Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
title_full Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
title_fullStr Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
title_full_unstemmed Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
title_sort Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
author Faria, D. R.
author_facet Faria, D. R.
Souza, P. E. A.
Durães, F. V.
Carvalho Filho, Edgar Marcelino de
Gollob, K. J.
Machado, Paulo Roberto Lima
Dutra, Walderez Ornelas
author_role author
author2 Souza, P. E. A.
Durães, F. V.
Carvalho Filho, Edgar Marcelino de
Gollob, K. J.
Machado, Paulo Roberto Lima
Dutra, Walderez Ornelas
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Faria, D. R.
Souza, P. E. A.
Durães, F. V.
Carvalho Filho, Edgar Marcelino de
Gollob, K. J.
Machado, Paulo Roberto Lima
Dutra, Walderez Ornelas
Faria, D. R.
Souza, P. E. A.
Durães, F. V.
Carvalho Filho, Edgar Marcelino de
Gollob, K. J.
Machado, Paulo Roberto Lima
Dutra, Walderez Ornelas
dc.subject.por.fl_str_mv CD8+ T cells
granzyme
leishmaniasis
lesion
progression
topic CD8+ T cells
granzyme
leishmaniasis
lesion
progression
description Trabalho completo: acesso restrito, p.432–439
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-07-09T19:48:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6383
dc.identifier.issn.none.fl_str_mv 0141-9838
dc.identifier.number.pt_BR.fl_str_mv v. 31, n. 8
identifier_str_mv 0141-9838
v. 31, n. 8
url http://www.repositorio.ufba.br/ri/handle/ri/6383
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.pt_BR.fl_str_mv http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2009.01125.x/pdf
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