Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease

Detalhes bibliográficos
Autor(a) principal: Seixas, Magda Oliveira
Data de Publicação: 2010
Outros Autores: Rocha, Larissa C., Carvalho, Mauricio B., Menezes, Joelma Figueiredo, Lyra, Isa Menezes, Nascimento, Valma M. L., Couto, Ricardo David, Atta, Ajax Mercês, Reis, Mitermayer G., Goncalves, Marilda S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5650
Resumo: p. 1-9.
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spelling Seixas, Magda OliveiraRocha, Larissa C.Carvalho, Mauricio B.Menezes, Joelma FigueiredoLyra, Isa MenezesNascimento, Valma M. L.Couto, Ricardo DavidAtta, Ajax MercêsReis, Mitermayer G.Goncalves, Marilda S.Seixas, Magda OliveiraRocha, Larissa C.Carvalho, Mauricio B.Menezes, Joelma FigueiredoLyra, Isa MenezesNascimento, Valma M. L.Couto, Ricardo DavidAtta, Ajax MercêsReis, Mitermayer G.Goncalves, Marilda S.2012-04-19T13:06:48Z2012-04-19T13:06:48Z20101476-511Xhttp://www.repositorio.ufba.br/ri/handle/ri/5650v. 9 n. 9.p. 1-9.Background: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up.We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steadystate children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, antiaggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. Methods: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. Results: Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005), bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001), aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol (P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of cholelithiasis. Conclusions: We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-04-19T13:06:48Z No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf: 223149 bytes, checksum: 4d0409861f587c25482b8f603787d683 (MD5)Made available in DSpace on 2012-04-19T13:06:48Z (GMT). No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf: 223149 bytes, checksum: 4d0409861f587c25482b8f603787d683 (MD5) Previous issue date: 2010DOI: 10.1186/1476-511X-9-91reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALevels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell diseaseLipids in Health and Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5650/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALC__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdfC__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdfapplication/pdf223149https://repositorio.ufba.br/bitstream/ri/5650/1/C__Documents%20and%20Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf4d0409861f587c25482b8f603787d683MD51TEXTC__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf.txtC__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf.txtExtracted texttext/plain37600https://repositorio.ufba.br/bitstream/ri/5650/3/C__Documents%20and%20Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf.txtf835170fedd6885d7426441caaa255a4MD53ri/56502022-07-05 14:03:21.847oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
dc.title.alternative.pt_BR.fl_str_mv Lipids in Health and Disease
title Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
spellingShingle Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
Seixas, Magda Oliveira
title_short Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
title_full Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
title_fullStr Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
title_full_unstemmed Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
title_sort Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
author Seixas, Magda Oliveira
author_facet Seixas, Magda Oliveira
Rocha, Larissa C.
Carvalho, Mauricio B.
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma M. L.
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer G.
Goncalves, Marilda S.
author_role author
author2 Rocha, Larissa C.
Carvalho, Mauricio B.
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma M. L.
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer G.
Goncalves, Marilda S.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Seixas, Magda Oliveira
Rocha, Larissa C.
Carvalho, Mauricio B.
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma M. L.
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer G.
Goncalves, Marilda S.
Seixas, Magda Oliveira
Rocha, Larissa C.
Carvalho, Mauricio B.
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma M. L.
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer G.
Goncalves, Marilda S.
description p. 1-9.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-04-19T13:06:48Z
dc.date.available.fl_str_mv 2012-04-19T13:06:48Z
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5650
dc.identifier.issn.none.fl_str_mv 1476-511X
dc.identifier.number.pt_BR.fl_str_mv v. 9 n. 9.
identifier_str_mv 1476-511X
v. 9 n. 9.
url http://www.repositorio.ufba.br/ri/handle/ri/5650
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dc.source.pt_BR.fl_str_mv DOI: 10.1186/1476-511X-9-91
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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