Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5860 |
Resumo: | Acesso restrito: Texto completo. p. 223-229 |
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Oliveira, Ricardo RiccioGollob, Kenneth JohnFigueiredo, Joanemile Pacheco deAlcântara, Leda MariaCardoso, Luciana SantosMota, Carolina Silva Barboza de AquinoCampos, Régis de AlbuquerqueAlmeida, Maria Cecilia Freitas deCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade SantosOliveira, Ricardo RiccioGollob, Kenneth JohnFigueiredo, Joanemile Pacheco deAlcântara, Leda MariaCardoso, Luciana SantosMota, Carolina Silva Barboza de AquinoCampos, Régis de AlbuquerqueAlmeida, Maria Cecilia Freitas deCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade Santos2012-05-14T19:46:20Z20091286-4579http://www.repositorio.ufba.br/ri/handle/ri/5860v. 11, n. 2Acesso restrito: Texto completo. p. 223-229Chronic schistosomiasis induces Th2/T regulatory responses which are able to down-modulate allergic inflammation and asthma. Because costimulatory molecules and IL-10 are essential for inducing tolerance, the aim of this study was to determine by flow cytometry, the expression of CD28, CTLA4, CD40L, CD80, CD86, HLA-DR, IL-10 and IL-10 receptor, by mononuclear cells from asthmatic individuals infected with Schistosoma mansoni and compare with non-infected individuals. Peripheral blood mononuclear cells were stained with fluorochrome conjugated antibodies for the expression of co-stimulatory molecules, and for intracellular CTLA4 and IL-10 expression. There was no significant difference in the frequency of T cells expressing CD28 between the two groups. However, the frequency of TCD4þ cells expressing CTLA4 and CD40L was higher in infected asthmatics. The frequency of monocytes expressing CD80 and CD86 did not differ between groups, while the expression of HLA-DR and IL-10 receptor was higher on monocytes of infected individuals. Furthermore, monocytes and CD4þCD25þ cells of infected individuals expressed higher levels of IL-10. We conclude that, besides alternatively-activated monocytes that are, together with CD4þCD25þ cells, important sources of IL-10, CTLA4 and CD40L expression may also participate in the down-modulation of inflammatory allergic response in S. mansoni-infected asthmatics. 2008 Published by Elsevier Masson SAS.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-14T19:46:20Z No. of bitstreams: 1 __ac.els-cdn.com_S128645...394140052c7ab44f4e8ab3f8ead00.pdf: 223764 bytes, checksum: 41bc4c409cfdbdcc550c17cec4248625 (MD5)Made available in DSpace on 2012-05-14T19:46:20Z (GMT). No. of bitstreams: 1 __ac.els-cdn.com_S128645...394140052c7ab44f4e8ab3f8ead00.pdf: 223764 bytes, checksum: 41bc4c409cfdbdcc550c17cec4248625 (MD5) Previous issue date: 2009http://dx.doi.org/10.1016/j.micinf.2008.11.017, How to Cite or Link Using DOI Cited by in Scopus (7)reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASchistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthmaMicrobes and Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5860/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL__ac.els-cdn.com_S128645...394140052c7ab44f4e8ab3f8ead00.pdf__ac.els-cdn.com_S128645...394140052c7ab44f4e8ab3f8ead00.pdfapplication/pdf223764https://repositorio.ufba.br/bitstream/ri/5860/1/__ac.els-cdn.com_S128645...394140052c7ab44f4e8ab3f8ead00.pdf41bc4c409cfdbdcc550c17cec4248625MD51TEXT__ac.els-cdn.com_S128645...394140052c7ab44f4e8ab3f8ead00.pdf.txt__ac.els-cdn.com_S128645...394140052c7ab44f4e8ab3f8ead00.pdf.txtExtracted texttext/plain34245https://repositorio.ufba.br/bitstream/ri/5860/3/__ac.els-cdn.com_S128645...394140052c7ab44f4e8ab3f8ead00.pdf.txt20279b31a8acc6905e4cc73b2abdc751MD53ri/58602022-07-05 14:03:10.573oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:10Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma |
| dc.title.alternative.pt_BR.fl_str_mv |
Microbes and Infection |
| title |
Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma |
| spellingShingle |
Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma Oliveira, Ricardo Riccio |
| title_short |
Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma |
| title_full |
Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma |
| title_fullStr |
Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma |
| title_full_unstemmed |
Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma |
| title_sort |
Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma |
| author |
Oliveira, Ricardo Riccio |
| author_facet |
Oliveira, Ricardo Riccio Gollob, Kenneth John Figueiredo, Joanemile Pacheco de Alcântara, Leda Maria Cardoso, Luciana Santos Mota, Carolina Silva Barboza de Aquino Campos, Régis de Albuquerque Almeida, Maria Cecilia Freitas de Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| author_role |
author |
| author2 |
Gollob, Kenneth John Figueiredo, Joanemile Pacheco de Alcântara, Leda Maria Cardoso, Luciana Santos Mota, Carolina Silva Barboza de Aquino Campos, Régis de Albuquerque Almeida, Maria Cecilia Freitas de Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Ricardo Riccio Gollob, Kenneth John Figueiredo, Joanemile Pacheco de Alcântara, Leda Maria Cardoso, Luciana Santos Mota, Carolina Silva Barboza de Aquino Campos, Régis de Albuquerque Almeida, Maria Cecilia Freitas de Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos Oliveira, Ricardo Riccio Gollob, Kenneth John Figueiredo, Joanemile Pacheco de Alcântara, Leda Maria Cardoso, Luciana Santos Mota, Carolina Silva Barboza de Aquino Campos, Régis de Albuquerque Almeida, Maria Cecilia Freitas de Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| description |
Acesso restrito: Texto completo. p. 223-229 |
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2009 |
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2009 |
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2012-05-14T19:46:20Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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1286-4579 |
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v. 11, n. 2 |
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1286-4579 v. 11, n. 2 |
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http://dx.doi.org/10.1016/j.micinf.2008.11.017, How to Cite or Link Using DOI Cited by in Scopus (7) |
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