Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study

Bibliographic Details
Main Author: Hounie, Ana Gabriela
Publication Date: 2007
Other Authors: Pauls, David L., Campos, Maria Conceição do Rosário, Mercadante, Marcos Tomanik, Diniz, Juliana Belo, Mathis, Maria Alice de, Mathis, Maria Eugênia de, Chacon, Priscila, Shavitt, Roseli Gedanke, Curi, Mariana, Guilherme, Luiza, Miguel, Euripedes Constantino
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://repositorio.ufba.br/ri/handle/ri/14814
Summary: Texto completo: acesso restrito. p. 266–272
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spelling Hounie, Ana GabrielaPauls, David L.Campos, Maria Conceição do RosárioMercadante, Marcos TomanikDiniz, Juliana BeloMathis, Maria Alice deMathis, Maria Eugênia deChacon, PriscilaShavitt, Roseli GedankeCuri, MarianaGuilherme, LuizaMiguel, Euripedes ConstantinoHounie, Ana GabrielaPauls, David L.Campos, Maria Conceição do RosárioMercadante, Marcos TomanikDiniz, Juliana BeloMathis, Maria Alice deMathis, Maria Eugênia deChacon, PriscilaShavitt, Roseli GedankeCuri, MarianaGuilherme, LuizaMiguel, Euripedes Constantino2014-04-09T13:56:37Z20070006-3223http://repositorio.ufba.br/ri/handle/ri/14814v. 61, n. 3Texto completo: acesso restrito. p. 266–272Background: Obsessive-compulsive spectrum disorders (OCSDs) are more frequent in patients with active or prior rheumatic fever (RF), suggesting that OCSD and RF may share underlying etiologic mechanisms. Our objective was to estimate the frequency of OCSD in first-degree relatives (FDRs) of RF patients and controls to determine whether there is a familial relationship between OCSD and RF. Methods: This is a case-control family study. Of the 98 probands included in this study, 31 had RF without Sydenham’s chorea (SC) and had 131 relatives, 28 had RF with SC and had 120 relatives, and 39 were controls without RF. All probands, 87.9% of the RF FDRs and 93.7% of the control FDRs were assessed directly with structured psychiatric interviews and best-estimate diagnoses were assigned. Odds ratios of morbid risks were estimated using logistic regression by the generalized estimating equations (GEE) method and compared between groups. Results: The rate of OCSDs was significantly higher among FDRs of RF probands than among FDRs of controls (n=37; 14.7% vs. n=10; 7.3%, i=.0279). A diagnosis of OCSDs in an RF proband was associated with a higher rate of OCSDs among FDRs when compared to control FDRs (p-GEE=.02). There was a trend for a higher rate of OCSDs among FDRs of RF probands presenting no OCSD, although the difference was not significant (p-GEE=.09). Conclusion: The results are consistent with the hypothesis that a familial relationship exists between OCSD and RF, since an OCSD in the RF proband was found to increase the risk of OCSDs among FDRs. Additional neuroimmunological and genetic studies involving larger samples are needed to further elucidate this apparent familial relationship between RF and OCSD.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-03-12T12:13:15Z No. of bitstreams: 1 1-s2.0-S0006322306002393-main.pdf: 122023 bytes, checksum: 085eababba16ac75fd34f7729d8c6f1d (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-04-09T13:56:37Z (GMT) No. of bitstreams: 1 1-s2.0-S0006322306002393-main.pdf: 122023 bytes, checksum: 085eababba16ac75fd34f7729d8c6f1d (MD5)Made available in DSpace on 2014-04-09T13:56:37Z (GMT). No. of bitstreams: 1 1-s2.0-S0006322306002393-main.pdf: 122023 bytes, checksum: 085eababba16ac75fd34f7729d8c6f1d (MD5) Previous issue date: 2007http://dx.doi.org/10.1016/j.biopsych.2006.02.021reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAFamily studyObsessive-compulsive disorderRheumatic feverTicsTouretteObsessive-Compulsive spectrum disorders and Rheumatic Fever: a family studyBiological Psychiatryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0006322306002393-main.pdf1-s2.0-S0006322306002393-main.pdfapplication/pdf122023https://repositorio.ufba.br/bitstream/ri/14814/1/1-s2.0-S0006322306002393-main.pdf085eababba16ac75fd34f7729d8c6f1dMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14814/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT1-s2.0-S0006322306002393-main.pdf.txt1-s2.0-S0006322306002393-main.pdf.txtExtracted texttext/plain39647https://repositorio.ufba.br/bitstream/ri/14814/3/1-s2.0-S0006322306002393-main.pdf.txt3232e3fea1cbe4f37df7aae97b0bc35eMD53ri/148142022-07-05 14:03:15.5oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:15Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study
dc.title.alternative.pt_BR.fl_str_mv Biological Psychiatry
title Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study
spellingShingle Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study
Hounie, Ana Gabriela
Family study
Obsessive-compulsive disorder
Rheumatic fever
Tics
Tourette
title_short Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study
title_full Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study
title_fullStr Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study
title_full_unstemmed Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study
title_sort Obsessive-Compulsive spectrum disorders and Rheumatic Fever: a family study
author Hounie, Ana Gabriela
author_facet Hounie, Ana Gabriela
Pauls, David L.
Campos, Maria Conceição do Rosário
Mercadante, Marcos Tomanik
Diniz, Juliana Belo
Mathis, Maria Alice de
Mathis, Maria Eugênia de
Chacon, Priscila
Shavitt, Roseli Gedanke
Curi, Mariana
Guilherme, Luiza
Miguel, Euripedes Constantino
author_role author
author2 Pauls, David L.
Campos, Maria Conceição do Rosário
Mercadante, Marcos Tomanik
Diniz, Juliana Belo
Mathis, Maria Alice de
Mathis, Maria Eugênia de
Chacon, Priscila
Shavitt, Roseli Gedanke
Curi, Mariana
Guilherme, Luiza
Miguel, Euripedes Constantino
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hounie, Ana Gabriela
Pauls, David L.
Campos, Maria Conceição do Rosário
Mercadante, Marcos Tomanik
Diniz, Juliana Belo
Mathis, Maria Alice de
Mathis, Maria Eugênia de
Chacon, Priscila
Shavitt, Roseli Gedanke
Curi, Mariana
Guilherme, Luiza
Miguel, Euripedes Constantino
Hounie, Ana Gabriela
Pauls, David L.
Campos, Maria Conceição do Rosário
Mercadante, Marcos Tomanik
Diniz, Juliana Belo
Mathis, Maria Alice de
Mathis, Maria Eugênia de
Chacon, Priscila
Shavitt, Roseli Gedanke
Curi, Mariana
Guilherme, Luiza
Miguel, Euripedes Constantino
dc.subject.por.fl_str_mv Family study
Obsessive-compulsive disorder
Rheumatic fever
Tics
Tourette
topic Family study
Obsessive-compulsive disorder
Rheumatic fever
Tics
Tourette
description Texto completo: acesso restrito. p. 266–272
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-04-09T13:56:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14814
dc.identifier.issn.none.fl_str_mv 0006-3223
dc.identifier.number.pt_BR.fl_str_mv v. 61, n. 3
identifier_str_mv 0006-3223
v. 61, n. 3
url http://repositorio.ufba.br/ri/handle/ri/14814
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.biopsych.2006.02.021
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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