High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population

Detalhes bibliográficos
Autor(a) principal: Grant, Audrey V.
Data de Publicação: 2008
Outros Autores: Araujo, Maria Ilma Andrade Santos, Ponte, Eduardo Vieira, Oliveira, Ricardo Riccio, Cruz Filho, Álvaro Augusto Souza da, Barnes, Kathleen C., Beaty, Terri H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13637
Resumo: Texto completo: acesso restrito. p. 1121-1131
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spelling Grant, Audrey V.Araujo, Maria Ilma Andrade SantosPonte, Eduardo VieiraOliveira, Ricardo RiccioCruz Filho, Álvaro Augusto Souza daBarnes, Kathleen C.Beaty, Terri H.Grant, Audrey V.Araujo, Maria Ilma Andrade SantosPonte, Eduardo VieiraOliveira, Ricardo RiccioCruz Filho, Álvaro Augusto Souza daBarnes, Kathleen C.Beaty, Terri H.2013-11-13T17:42:26Z20080022-1899http://repositorio.ufba.br/ri/handle/ri/13637v. 198, n. 8Texto completo: acesso restrito. p. 1121-1131Background. Evidence of genetic control for total serum IgE (tIgE) level has been reported in multiple populations, although populations with substantial exposure to helminths have yielded lower estimates of heritability, despite evidence suggesting that genes also control a significant portion of the variation in the number of Schistosoma mansoni eggs per gram of fecal matter. Methods. By use of a whole-population ascertainment scheme, 822 individuals were enrolled from a schistosomiasis-endemic area in Conde, Bahia, in Brazil. Heritability was estimated by using an additive polygenic model, and segregation analysis was performed for 2 quantitative traits, tIgE level and egg count. Results. After adjusting for nongenetic covariates, the heritability of log-transformed tIgE level and logtransformed egg count was estimated at 60% and 31%, respectively. No evidence for a single major gene controlling tIgE level or egg count was observed in segregation analysis for 781 individuals and 403 individuals, respectively, in 318 families, however, which suggests complex biological control. Conclusions. The high heritability of tIgE level indicates that genetic factors are likely to control tIgE level even in the presence of helminthic infection. Substantial heritability for the burden of S. mansoni infection was confirmed in these Brazilian families. Further genetic studies will be needed to dissect the specific genetic factors that underlie these traits.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-08T12:50:58Z No. of bitstreams: 1 J Infect Dis.-2008-Grant-1227-36.pdf: 248409 bytes, checksum: dd8e6b439298f959b6af4c69da79ecf8 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-13T17:42:26Z (GMT) No. of bitstreams: 1 J Infect Dis.-2008-Grant-1227-36.pdf: 248409 bytes, checksum: dd8e6b439298f959b6af4c69da79ecf8 (MD5)Made available in DSpace on 2013-11-13T17:42:26Z (GMT). No. of bitstreams: 1 J Infect Dis.-2008-Grant-1227-36.pdf: 248409 bytes, checksum: dd8e6b439298f959b6af4c69da79ecf8 (MD5) Previous issue date: 2009http://dx.doi.org/10.1086/591946reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHigh heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian populationJournal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALJ Infect Dis.-2008-Grant-1227-36.pdfJ Infect Dis.-2008-Grant-1227-36.pdfapplication/pdf248409https://repositorio.ufba.br/bitstream/ri/13637/1/J%20Infect%20Dis.-2008-Grant-1227-36.pdfdd8e6b439298f959b6af4c69da79ecf8MD51LICENSElicense.txtlicense.txttext/plain1383https://repositorio.ufba.br/bitstream/ri/13637/2/license.txt05eca2f01d0b3307819d0369dab18a34MD52TEXTJ Infect Dis.-2008-Grant-1227-36.pdf.txtJ Infect Dis.-2008-Grant-1227-36.pdf.txtExtracted texttext/plain47194https://repositorio.ufba.br/bitstream/ri/13637/3/J%20Infect%20Dis.-2008-Grant-1227-36.pdf.txt968a3f9be4426ba9f6d2168a0004bcdcMD53ri/136372022-09-22 10:20:25.655oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-09-22T13:20:25Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
dc.title.alternative.pt_BR.fl_str_mv Journal of Infectious Diseases
title High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
spellingShingle High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
Grant, Audrey V.
title_short High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
title_full High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
title_fullStr High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
title_full_unstemmed High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
title_sort High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
author Grant, Audrey V.
author_facet Grant, Audrey V.
Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Cruz Filho, Álvaro Augusto Souza da
Barnes, Kathleen C.
Beaty, Terri H.
author_role author
author2 Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Cruz Filho, Álvaro Augusto Souza da
Barnes, Kathleen C.
Beaty, Terri H.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grant, Audrey V.
Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Cruz Filho, Álvaro Augusto Souza da
Barnes, Kathleen C.
Beaty, Terri H.
Grant, Audrey V.
Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Cruz Filho, Álvaro Augusto Souza da
Barnes, Kathleen C.
Beaty, Terri H.
description Texto completo: acesso restrito. p. 1121-1131
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-11-13T17:42:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13637
dc.identifier.issn.none.fl_str_mv 0022-1899
dc.identifier.number.pt_BR.fl_str_mv v. 198, n. 8
identifier_str_mv 0022-1899
v. 198, n. 8
url http://repositorio.ufba.br/ri/handle/ri/13637
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1086/591946
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