Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13749 |
Resumo: | Texto completo: acesso restrito. p. 455-462 |
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Nascimento, M. C. F.Leite Primo, Janeusa RitaBittencourt, Achilea Candida LisboaSiqueira, I.Oliveira, M. de FátimaNascimento, Roberto José MeyerSchriefer, Nicolaus Albert BorgesSantos, S. B.Carvalho Filho, Edgar Marcelino deNascimento, M. C. F.Leite Primo, Janeusa RitaBittencourt, Achilea Candida LisboaSiqueira, I.Oliveira, M. de FátimaNascimento, Roberto José MeyerSchriefer, Nicolaus Albert BorgesSantos, S. B.Carvalho Filho, Edgar Marcelino de2013-11-19T20:01:13Z20090009-9104http://repositorio.ufba.br/ri/handle/ri/13749v. 156, n. 3Texto completo: acesso restrito. p. 455-462Human T lymphotropic virus-type 1 (HTLV-1) is the causal agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T cell leukaemia/lymphoma and infective dermatitis associated with HTLV-1 (IDH). Over-production of proinflammatory cytokines and an increase in HTLV-1 proviral load are features of HAM/TSP, but the immunological basis of IDH has not been established. In addition to severe cutaneous manifestations, the importance of IDH relies on the observation that up to 30% of children with IDH develop HAM/TSP in childhood and adolescence. In this study we determined the immune response in patients with IDH measuring interleukin (IL)-4, IL-5, IL-10, interferon (IFN)-γ and tumour necrosis factor (TNF)-α levels as well as the HTLV-1 proviral load. Additionally, regulatory cytokines and anti-cytokines were added to cultures to evaluate the ability of these molecules to down-modulate TNF-α and IFN-γ synthesis. HTLV-1 carriers and patients with HAM/TSP served as controls. TNF-α and IFN-γ levels were higher in IDH than in HTLV-1 carriers. There was no difference in IFN-γ and TNF-α concentrations in IDH and HAM/TSP patients. There was a tendency for higher IL-4 mRNA expression and immunoglobulin E (IgE) levels in IDH than in HTLV-1 carriers, but the difference did not reach statistical significance. The HTLV-1 proviral load was significantly higher in IDH patients than in HTLV-1 carriers. IDH is characterized by an exaggerated Th1 immune response and high HTLV-1 proviral load. The similarities between the immunological response in patients with IDH and HAM/TSP and the high proviral load observed in IDH provide support that IDH is a risk factor for development of HAM/TSP.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-11T11:31:02Z No. of bitstreams: 1 j.1365-2249.2008.03869.x.pdf: 353199 bytes, checksum: eeb6d05c544ac17ae54deed87e068f8b (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-19T20:01:13Z (GMT) No. of bitstreams: 1 j.1365-2249.2008.03869.x.pdf: 353199 bytes, checksum: eeb6d05c544ac17ae54deed87e068f8b (MD5)Made available in DSpace on 2013-11-19T20:01:13Z (GMT). No. of bitstreams: 1 j.1365-2249.2008.03869.x.pdf: 353199 bytes, checksum: eeb6d05c544ac17ae54deed87e068f8b (MD5) Previous issue date: 2009http://dx.doi.org/10.1111/j.1365-2249.2008.03869.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACytokines/interleukinsDermatological infectionsHTLV-I/IIInfective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesisClinical and Experimental Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALj.1365-2249.2008.03869.x.pdfj.1365-2249.2008.03869.x.pdfapplication/pdf353199https://repositorio.ufba.br/bitstream/ri/13749/1/j.1365-2249.2008.03869.x.pdfeeb6d05c544ac17ae54deed87e068f8bMD51LICENSElicense.txtlicense.txttext/plain1365https://repositorio.ufba.br/bitstream/ri/13749/2/license.txt5371a150bdc863f78dcf39281543bd86MD52TEXTj.1365-2249.2008.03869.x.pdf.txtj.1365-2249.2008.03869.x.pdf.txtExtracted texttext/plain35164https://repositorio.ufba.br/bitstream/ri/13749/3/j.1365-2249.2008.03869.x.pdf.txt2d897fa50a042b66d3365aa343ea45baMD53ri/137492022-07-05 14:03:28.263oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis |
| dc.title.alternative.pt_BR.fl_str_mv |
Clinical and Experimental Immunology |
| title |
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis |
| spellingShingle |
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis Nascimento, M. C. F. Cytokines/interleukins Dermatological infections HTLV-I/II |
| title_short |
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis |
| title_full |
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis |
| title_fullStr |
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis |
| title_full_unstemmed |
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis |
| title_sort |
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis |
| author |
Nascimento, M. C. F. |
| author_facet |
Nascimento, M. C. F. Leite Primo, Janeusa Rita Bittencourt, Achilea Candida Lisboa Siqueira, I. Oliveira, M. de Fátima Nascimento, Roberto José Meyer Schriefer, Nicolaus Albert Borges Santos, S. B. Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Leite Primo, Janeusa Rita Bittencourt, Achilea Candida Lisboa Siqueira, I. Oliveira, M. de Fátima Nascimento, Roberto José Meyer Schriefer, Nicolaus Albert Borges Santos, S. B. Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nascimento, M. C. F. Leite Primo, Janeusa Rita Bittencourt, Achilea Candida Lisboa Siqueira, I. Oliveira, M. de Fátima Nascimento, Roberto José Meyer Schriefer, Nicolaus Albert Borges Santos, S. B. Carvalho Filho, Edgar Marcelino de Nascimento, M. C. F. Leite Primo, Janeusa Rita Bittencourt, Achilea Candida Lisboa Siqueira, I. Oliveira, M. de Fátima Nascimento, Roberto José Meyer Schriefer, Nicolaus Albert Borges Santos, S. B. Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Cytokines/interleukins Dermatological infections HTLV-I/II |
| topic |
Cytokines/interleukins Dermatological infections HTLV-I/II |
| description |
Texto completo: acesso restrito. p. 455-462 |
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2009 |
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2009 |
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2013-11-19T20:01:13Z |
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0009-9104 |
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v. 156, n. 3 |
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0009-9104 v. 156, n. 3 |
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