Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil

Detalhes bibliográficos
Autor(a) principal: Focaccia, R.
Data de Publicação: 2004
Outros Autores: Baraldo, D. C. M., Ferraz, M. L. G., Martinelli, A. L. C., Carrilho, F. J., Gonçales Júnior, F. L., Pedroso, M. L. A., Coelho, H. S. M., Lacerda, M. A., Brandão, C. E., Mattos, A. A., Lira, L. G. C., Zamin Júnior, I., Pinheiro, J. O. P., Tovo, C. V., Both, C. T., Soares, J. A. S., Dittrich, S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6897
Resumo: p.348-355
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spelling Focaccia, R.Baraldo, D. C. M.Ferraz, M. L. G.Martinelli, A. L. C.Carrilho, F. J.Gonçales Júnior, F. L.Pedroso, M. L. A.Coelho, H. S. M.Lacerda, M. A.Brandão, C. E.Mattos, A. A.Lira, L. G. C.Zamin Júnior, I.Pinheiro, J. O. P.Tovo, C. V.Both, C. T.Soares, J. A. S.Dittrich, S.Focaccia, R.Baraldo, D. C. M.Ferraz, M. L. G.Martinelli, A. L. C.Carrilho, F. J.Gonçales Júnior, F. L.Pedroso, M. L. A.Coelho, H. S. M.Lacerda, M. A.Brandão, C. E.Mattos, A. A.Lira, L. G. C.Zamin Júnior, I.Pinheiro, J. O. P.Tovo, C. V.Both, C. T.Soares, J. A. S.Dittrich, S.2012-10-08T19:44:50Z2012-10-08T19:44:50Z2004-101413-8670http://www.repositorio.ufba.br/ri/handle/ri/6897v. 8, n. 5p.348-355Hepatitis C virus (HCV) infection is a serious public health problem, since 80% to 85% of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma. Considering that the response of hepatitis C patients to combination therapy with interferon and ribavirin depends on HCV characteristics as well as on host features, we made a retrospective analysis of demographic and anthropometrical data and HCV genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil. The medical records of 4,996 patients were reviewed, 81% from public and 19% from private institutions. Patients' median age was 46 years, and there was a higher prevalence of male (62%) and white patients (80%). The analysis of HCV-infecting strains showed a predominance of genotype 1 (64%) over genotypes 2 and 3. The patients' mean weight was 70.6 kg, and 65% of the patients weighed less than 77kg. Overweight and obesity were observed in 37.8% and 13.6% of the patients, respectively. Since a body weight of 75 kg or less has been considered an independent factor that significantly increases the odds of achieving a sustained virological response, the Brazilian population seems to have a more favorable body weight profile to achieve a sustained response than the American and European populations. The finding that 65% of chronic hepatitis C patients have a body weight of 77 kg or less may have a positive pharmacoeconomic impact on the treatment of genotype 1 HCV patients with weight-based doses of peginterferon.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-10-08T19:44:50Z No. of bitstreams: 1 Focaccia, R..pdf: 157205 bytes, checksum: 7a99546adbce3f4da4fa6ccb59cff3b8 (MD5)Made available in DSpace on 2012-10-08T19:44:50Z (GMT). No. of bitstreams: 1 Focaccia, R..pdf: 157205 bytes, checksum: 7a99546adbce3f4da4fa6ccb59cff3b8 (MD5) Previous issue date: 2004-10SalvadorThe Brazilian Journal of Infectious Diseases and Contexto Publishinghttp://dx.doi.org/10.1590/S1413-86702004000500003reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHCVChronic hepatitis CGenotypeBody weightBrazilDemographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in BrazilBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALFocaccia, R..pdfFocaccia, R..pdfapplication/pdf157205https://repositorio.ufba.br/bitstream/ri/6897/1/Focaccia%2c%20R..pdf7a99546adbce3f4da4fa6ccb59cff3b8MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6897/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTFocaccia, R..pdf.txtFocaccia, R..pdf.txtExtracted texttext/plain20657https://repositorio.ufba.br/bitstream/ri/6897/3/Focaccia%2c%20R..pdf.txt95293c87f05226612a9db84b0eb0463aMD53ri/68972022-07-05 14:04:04.153oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:04Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
spellingShingle Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
Focaccia, R.
HCV
Chronic hepatitis C
Genotype
Body weight
Brazil
title_short Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
title_full Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
title_fullStr Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
title_full_unstemmed Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
title_sort Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
author Focaccia, R.
author_facet Focaccia, R.
Baraldo, D. C. M.
Ferraz, M. L. G.
Martinelli, A. L. C.
Carrilho, F. J.
Gonçales Júnior, F. L.
Pedroso, M. L. A.
Coelho, H. S. M.
Lacerda, M. A.
Brandão, C. E.
Mattos, A. A.
Lira, L. G. C.
Zamin Júnior, I.
Pinheiro, J. O. P.
Tovo, C. V.
Both, C. T.
Soares, J. A. S.
Dittrich, S.
author_role author
author2 Baraldo, D. C. M.
Ferraz, M. L. G.
Martinelli, A. L. C.
Carrilho, F. J.
Gonçales Júnior, F. L.
Pedroso, M. L. A.
Coelho, H. S. M.
Lacerda, M. A.
Brandão, C. E.
Mattos, A. A.
Lira, L. G. C.
Zamin Júnior, I.
Pinheiro, J. O. P.
Tovo, C. V.
Both, C. T.
Soares, J. A. S.
Dittrich, S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Focaccia, R.
Baraldo, D. C. M.
Ferraz, M. L. G.
Martinelli, A. L. C.
Carrilho, F. J.
Gonçales Júnior, F. L.
Pedroso, M. L. A.
Coelho, H. S. M.
Lacerda, M. A.
Brandão, C. E.
Mattos, A. A.
Lira, L. G. C.
Zamin Júnior, I.
Pinheiro, J. O. P.
Tovo, C. V.
Both, C. T.
Soares, J. A. S.
Dittrich, S.
Focaccia, R.
Baraldo, D. C. M.
Ferraz, M. L. G.
Martinelli, A. L. C.
Carrilho, F. J.
Gonçales Júnior, F. L.
Pedroso, M. L. A.
Coelho, H. S. M.
Lacerda, M. A.
Brandão, C. E.
Mattos, A. A.
Lira, L. G. C.
Zamin Júnior, I.
Pinheiro, J. O. P.
Tovo, C. V.
Both, C. T.
Soares, J. A. S.
Dittrich, S.
dc.subject.por.fl_str_mv HCV
Chronic hepatitis C
Genotype
Body weight
Brazil
topic HCV
Chronic hepatitis C
Genotype
Body weight
Brazil
description p.348-355
publishDate 2004
dc.date.issued.fl_str_mv 2004-10
dc.date.accessioned.fl_str_mv 2012-10-08T19:44:50Z
dc.date.available.fl_str_mv 2012-10-08T19:44:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6897
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 8, n. 5
identifier_str_mv 1413-8670
v. 8, n. 5
url http://www.repositorio.ufba.br/ri/handle/ri/6897
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1413-86702004000500003
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
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