Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S1678-9946201759067 https://repositorio.unifesp.br/handle/11600/55442 |
Resumo: | Despite recent advances in therapy for chronic hepatitis C (CHC), the disease caused by genotype 3 virus (GEN3) is still considered a treatment challenge in certain patient subgroups. The aim of this retrospective study was to evaluate the effectiveness and safety of the peginterferon (Peg-IFN) and ribavirin (RBV) combination treatment for GEN3/CHC patients, and to evaluate sustained virological response (SVR) indicators and early treatment interruption due to serious adverse events (SAE). This was a retrospective observational study of GEN3/CHC patients, co-infected or not by HIV and treated with Peg-IFN/RBV in nine Brazilian healthcare centers. The study sample included 184 GEN3/CHC patients |
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Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virusHepatitis CChronic hepatitis CCoinfection HCV-HIVInterferonsRibavirinHCV genotypesDespite recent advances in therapy for chronic hepatitis C (CHC), the disease caused by genotype 3 virus (GEN3) is still considered a treatment challenge in certain patient subgroups. The aim of this retrospective study was to evaluate the effectiveness and safety of the peginterferon (Peg-IFN) and ribavirin (RBV) combination treatment for GEN3/CHC patients, and to evaluate sustained virological response (SVR) indicators and early treatment interruption due to serious adverse events (SAE). This was a retrospective observational study of GEN3/CHC patients, co-infected or not by HIV and treated with Peg-IFN/RBV in nine Brazilian healthcare centers. The study sample included 184 GEN3/CHC patients70 (38%) were co-infected with HIV. The overall SVR rate was 57.1% (95% CI 50-64). Among co-infected and mono-infected patients, the SVR rate was 51.4% (36/70) and 60.5% (69/114), respectively (p=0.241). Thirty-four (18.5%) patients experienced SAE and interrupted treatment. SVR was negatively associated with the use of Peg-IFN alpha 2b (PR 0.7595% CI 0.58-0.99p=0.045) and to early treatment interruption due to SAE (PR 0.3695% CI 0.20-0.68p=0.001). Early treatment interruption due to SAE was associated with age (PR 1.0695% CI 1.02-1.10p<0.001) and occurrence of liver cirrhosis (PR 2.0695% CI 1.11-3.83p=0.022). In conclusion, Peg-IFN/RBV might represent an adequate treatment option, mainly in young patients without advanced liver disease or when the use of direct-action drugs is limited to specific patient groups.Univ Sul Santa Catarina, Fac Med, Dept Ciencias Biol & Saude & Ciencias Sociais Apl, Disciplina Doencas Infecciosas, Av Pedra Branca 25, BR-88137270 Palhoca, SC, BrazilUniv Fed Sao Paulo, Disciplina Infectol, Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Med, Div Gastroenterol & Hepatol, Sao Paulo, SP, BrazilUniv Fed Estado Rio de Janeiro, Dept Clin Med, Disciplina Gastroenterol, Rio De Janeiro, RJ, BrazilUniv Fed Espirito Santo, Serv Infectol, Vitoria, ES, SpainUniv Sao Paulo, Fac Med Ribeirao Preto, Div Gastroenterol, Ribeirao Preto, SP, BrazilInst Infectol Emilio Ribas, Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Med, Dept Doencas Infecciosas & Parasitarias, Sao Paulo, SP, BrazilSecretaria Estadual Saude, Unidade Mista Saude, Unimista 508 509, Brasilia, DF, BrazilUniv Sao Paulo, Inst Med Trop Sao Paulo, Lab Virol, LIM 52, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Disciplina Infectol, Sao Paulo, SP, BrazilWeb of ScienceInst Medicina Tropical Sao Paulo2020-07-17T14:03:30Z2020-07-17T14:03:30Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1590/S1678-9946201759067Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.10.1590/S1678-9946201759067S0036-46652017005000239.pdf0036-4665S0036-46652017005000239https://repositorio.unifesp.br/handle/11600/55442WOS:000414712400001engRevista Do Instituto De Medicina Tropical De Sao PauloSao Pauloinfo:eu-repo/semantics/openAccessGrando, Aline VitaliAbrao Ferreira, Paulo Roberto [UNIFESP]Pessoa, Mario Guimaraesde Campos Mazo, Daniel FerrazBrandao-Mello, Carlos EduardoReuter, TaniaCandolo Martinelli, Ana de LourdesGonzalez, Mario PeribanezSeixas-Santos Nastri, Ana CatharinaCampos, Aleia FaustinaBanks Ferreira Lopes, Max IgorUrbaez Brito, Jose DavidMendes-Correa, Maria Cassiareponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T07:13:25Zoai:repositorio.unifesp.br/:11600/55442Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T07:13:25Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| spellingShingle |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus Grando, Aline Vitali Hepatitis C Chronic hepatitis C Coinfection HCV-HIV Interferons Ribavirin HCV genotypes |
| title_short |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title_full |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title_fullStr |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title_full_unstemmed |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title_sort |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| author |
Grando, Aline Vitali |
| author_facet |
Grando, Aline Vitali Abrao Ferreira, Paulo Roberto [UNIFESP] Pessoa, Mario Guimaraes de Campos Mazo, Daniel Ferraz Brandao-Mello, Carlos Eduardo Reuter, Tania Candolo Martinelli, Ana de Lourdes Gonzalez, Mario Peribanez Seixas-Santos Nastri, Ana Catharina Campos, Aleia Faustina Banks Ferreira Lopes, Max Igor Urbaez Brito, Jose David Mendes-Correa, Maria Cassia |
| author_role |
author |
| author2 |
Abrao Ferreira, Paulo Roberto [UNIFESP] Pessoa, Mario Guimaraes de Campos Mazo, Daniel Ferraz Brandao-Mello, Carlos Eduardo Reuter, Tania Candolo Martinelli, Ana de Lourdes Gonzalez, Mario Peribanez Seixas-Santos Nastri, Ana Catharina Campos, Aleia Faustina Banks Ferreira Lopes, Max Igor Urbaez Brito, Jose David Mendes-Correa, Maria Cassia |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Grando, Aline Vitali Abrao Ferreira, Paulo Roberto [UNIFESP] Pessoa, Mario Guimaraes de Campos Mazo, Daniel Ferraz Brandao-Mello, Carlos Eduardo Reuter, Tania Candolo Martinelli, Ana de Lourdes Gonzalez, Mario Peribanez Seixas-Santos Nastri, Ana Catharina Campos, Aleia Faustina Banks Ferreira Lopes, Max Igor Urbaez Brito, Jose David Mendes-Correa, Maria Cassia |
| dc.subject.por.fl_str_mv |
Hepatitis C Chronic hepatitis C Coinfection HCV-HIV Interferons Ribavirin HCV genotypes |
| topic |
Hepatitis C Chronic hepatitis C Coinfection HCV-HIV Interferons Ribavirin HCV genotypes |
| description |
Despite recent advances in therapy for chronic hepatitis C (CHC), the disease caused by genotype 3 virus (GEN3) is still considered a treatment challenge in certain patient subgroups. The aim of this retrospective study was to evaluate the effectiveness and safety of the peginterferon (Peg-IFN) and ribavirin (RBV) combination treatment for GEN3/CHC patients, and to evaluate sustained virological response (SVR) indicators and early treatment interruption due to serious adverse events (SAE). This was a retrospective observational study of GEN3/CHC patients, co-infected or not by HIV and treated with Peg-IFN/RBV in nine Brazilian healthcare centers. The study sample included 184 GEN3/CHC patients |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2020-07-17T14:03:30Z 2020-07-17T14:03:30Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-9946201759067 Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017. 10.1590/S1678-9946201759067 S0036-46652017005000239.pdf 0036-4665 S0036-46652017005000239 https://repositorio.unifesp.br/handle/11600/55442 WOS:000414712400001 |
| url |
http://dx.doi.org/10.1590/S1678-9946201759067 https://repositorio.unifesp.br/handle/11600/55442 |
| identifier_str_mv |
Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017. 10.1590/S1678-9946201759067 S0036-46652017005000239.pdf 0036-4665 S0036-46652017005000239 WOS:000414712400001 |
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eng |
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eng |
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Revista Do Instituto De Medicina Tropical De Sao Paulo |
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info:eu-repo/semantics/openAccess |
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openAccess |
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- application/pdf |
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Sao Paulo |
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Inst Medicina Tropical Sao Paulo |
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Inst Medicina Tropical Sao Paulo |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268460438388736 |