Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Vilas Bôas, Deise Souza
Data de Publicação: 2013
Outros Autores: Takiya, Christina Maeda, Gurgel, Clarissa Araújo Silva, Cabral, Márcia Grillo, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15137
Resumo: p. 194-199
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spelling Vilas Bôas, Deise SouzaTakiya, Christina MaedaGurgel, Clarissa Araújo SilvaCabral, Márcia GrilloSantos, Jean Nunes dosVilas Bôas, Deise SouzaTakiya, Christina MaedaGurgel, Clarissa Araújo SilvaCabral, Márcia GrilloSantos, Jean Nunes dos2014-07-07T20:32:54Z2014-07-07T20:32:54Z20130103-6440http://repositorio.ufba.br/ri/handle/ri/15137v. 24, n. 3p. 194-199Tumor-associated macrophages (TAM) are the main cellular component in stroma of many tumors and participate in tumor angiogenesis. The aim of present study was to compare the microvascular density (MVD) and infiltrating macrophage density (IMD) in oral squamous cell carcinomas (OSCCs) with different histological grades. A histomorphometric analysis was performed after immunohistochemistry using antibodies such as von-Willebrand factor and CD68. A significant difference in MVD was found between well and moderately differentiated OSCCs (p<0.05). TAM were largely present in all studied tumors and the IMD was not different among OSCCs with different histological grades (p=0.381). Significant correlation between MVD and IMD was not observed (p=0.870). In conclusion, these results suggest that TAM and angiogenesis have an influence at different histological grades of OSCC. However, the lack of correlation between MVD and IMD could suggest that angiogenesis does not depend on the number of macrophages present in OSCC, but their predominant phenotype. Further studies involving distinct phenotypes of macrophages should be done to better understand the influence of TAM on the tumor angiogenesis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-13T11:19:57Z No. of bitstreams: 1 0103-6440-bdj-24-03-194.pdf: 4115297 bytes, checksum: 605b0cc05a14be329bc514a6bf1ea21d (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-07-07T20:32:54Z (GMT) No. of bitstreams: 1 0103-6440-bdj-24-03-194.pdf: 4115297 bytes, checksum: 605b0cc05a14be329bc514a6bf1ea21d (MD5)Made available in DSpace on 2014-07-07T20:32:54Z (GMT). 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dc.title.pt_BR.fl_str_mv Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma
dc.title.alternative.pt_BR.fl_str_mv Brazilian Dental Journal
title Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma
spellingShingle Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma
Vilas Bôas, Deise Souza
Angiogenesis
Macrophages
Oral squamous cell carcinoma
Immunohistochemistry
title_short Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma
title_full Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma
title_fullStr Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma
title_full_unstemmed Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma
title_sort Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma
author Vilas Bôas, Deise Souza
author_facet Vilas Bôas, Deise Souza
Takiya, Christina Maeda
Gurgel, Clarissa Araújo Silva
Cabral, Márcia Grillo
Santos, Jean Nunes dos
author_role author
author2 Takiya, Christina Maeda
Gurgel, Clarissa Araújo Silva
Cabral, Márcia Grillo
Santos, Jean Nunes dos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vilas Bôas, Deise Souza
Takiya, Christina Maeda
Gurgel, Clarissa Araújo Silva
Cabral, Márcia Grillo
Santos, Jean Nunes dos
Vilas Bôas, Deise Souza
Takiya, Christina Maeda
Gurgel, Clarissa Araújo Silva
Cabral, Márcia Grillo
Santos, Jean Nunes dos
dc.subject.por.fl_str_mv Angiogenesis
Macrophages
Oral squamous cell carcinoma
Immunohistochemistry
topic Angiogenesis
Macrophages
Oral squamous cell carcinoma
Immunohistochemistry
description p. 194-199
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-07-07T20:32:54Z
dc.date.available.fl_str_mv 2014-07-07T20:32:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15137
dc.identifier.issn.none.fl_str_mv 0103-6440
dc.identifier.number.pt_BR.fl_str_mv v. 24, n. 3
identifier_str_mv 0103-6440
v. 24, n. 3
url http://repositorio.ufba.br/ri/handle/ri/15137
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/0103-6440201302049
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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