Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5675 |
Resumo: | Acesso restrito: Texto completo. p. 565-570. |
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Vilas Bôas, Deise SouzaTakiya, Christina MaedaCoelho-Sampaio, Tatiana LoboMonção-Ribeiro, Leonardo CamposRamos, Eduardo Antônio GonçalvesCabral, Márcia GrilloSantos, Jean Nunes dosVilas Bôas, Deise SouzaTakiya, Christina MaedaCoelho-Sampaio, Tatiana LoboMonção-Ribeiro, Leonardo CamposRamos, Eduardo Antônio GonçalvesCabral, Márcia GrilloSantos, Jean Nunes dos2012-04-19T18:53:22Z20100904-2512http://www.repositorio.ufba.br/ri/handle/ri/5675v. 39, n. 7Acesso restrito: Texto completo. p. 565-570.An inflammatory component consisting of cells and chemical mediators may influence the proliferation and dissemination of the oral squamous cell carcinoma (OSCC). In the present study, we evaluated the possible relationship between Ki-67, tumor-associate macrophages (TAMs), and COX-2 in OSCCs. In addition, the immunodetection of these proteins was associated with different histological grades of malignancy, including invasive and in situ tumors. METHODS: Twenty-seven OSCC cases were examined by light microscopy using criteria adopted WHO, and immunohistochemistry for Ki-67, CD68, and COX-2 using EnVision System in invasive and in situ lesions. Immunohistochemical detection of these proteins was assessed and scored for COX-2, and results were compared with their histological grades of malignancy. RESULTS: A correlation between Ki-67, COX-2, and CD68 was not found. Histological grade of malignancy (HDM) was associated with the Ki-67 immunostaining(P = 0.00), but this was not observed regarding both CD68 (P = 0.51) and COX-2 (P = 0.89). Furthermore, there was a COX-2 overexpression in 62.96% of the sample, and a high density of TAMs in both OSCCs and in situ carcinomas. CONCLUSIONS: Imunolabeling for Ki-67 was directly correlated with less-differentiated tumors, suggesting that this marker may contribute to understand the biological behavior of OSCC, and help to distinguish risk groups of OSCC. Furthermore, the lack of correlation between Ki-67, COX-2, and CD68 indicates that the latter two markers may play a pivotal role in oral carcinogenesis. However, further studies are needed to clarify their contribution for cell proliferation and tumor differentiationSubmitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-04-19T18:53:22Z No. of bitstreams: 1 __onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdf: 280288 bytes, checksum: 2b8e4eff237205424ba672214b95247e (MD5)Made available in DSpace on 2012-04-19T18:53:22Z (GMT). No. of bitstreams: 1 __onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdf: 280288 bytes, checksum: 2b8e4eff237205424ba672214b95247e (MD5) Previous issue date: 2010-08DOI: 10.1111/j.1600-0714.2010.00883.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAcyclooxygenase-2immunohistochemistryKi-67Macrophagessquamous cell carcinomaImmunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinomaJournal of Oral Pathology & Medicineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdf__onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdfapplication/pdf280288https://repositorio.ufba.br/bitstream/ri/5675/1/__onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdf2b8e4eff237205424ba672214b95247eMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5675/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdf.txt__onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdf.txtExtracted texttext/plain30264https://repositorio.ufba.br/bitstream/ri/5675/3/__onlinelibrary.wiley.co...6ba7216fccdef98ac0aa34d8faa27.pdf.txt489e24855efe4024d4ca7bde68bcf453MD53ri/56752022-10-31 21:58:38.21oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-11-01T00:58:38Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Oral Pathology & Medicine |
| title |
Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma |
| spellingShingle |
Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma Vilas Bôas, Deise Souza cyclooxygenase-2 immunohistochemistry Ki-67 Macrophages squamous cell carcinoma |
| title_short |
Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma |
| title_full |
Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma |
| title_fullStr |
Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma |
| title_full_unstemmed |
Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma |
| title_sort |
Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma |
| author |
Vilas Bôas, Deise Souza |
| author_facet |
Vilas Bôas, Deise Souza Takiya, Christina Maeda Coelho-Sampaio, Tatiana Lobo Monção-Ribeiro, Leonardo Campos Ramos, Eduardo Antônio Gonçalves Cabral, Márcia Grillo Santos, Jean Nunes dos |
| author_role |
author |
| author2 |
Takiya, Christina Maeda Coelho-Sampaio, Tatiana Lobo Monção-Ribeiro, Leonardo Campos Ramos, Eduardo Antônio Gonçalves Cabral, Márcia Grillo Santos, Jean Nunes dos |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Vilas Bôas, Deise Souza Takiya, Christina Maeda Coelho-Sampaio, Tatiana Lobo Monção-Ribeiro, Leonardo Campos Ramos, Eduardo Antônio Gonçalves Cabral, Márcia Grillo Santos, Jean Nunes dos Vilas Bôas, Deise Souza Takiya, Christina Maeda Coelho-Sampaio, Tatiana Lobo Monção-Ribeiro, Leonardo Campos Ramos, Eduardo Antônio Gonçalves Cabral, Márcia Grillo Santos, Jean Nunes dos |
| dc.subject.por.fl_str_mv |
cyclooxygenase-2 immunohistochemistry Ki-67 Macrophages squamous cell carcinoma |
| topic |
cyclooxygenase-2 immunohistochemistry Ki-67 Macrophages squamous cell carcinoma |
| description |
Acesso restrito: Texto completo. p. 565-570. |
| publishDate |
2010 |
| dc.date.issued.fl_str_mv |
2010 |
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2012-04-19T18:53:22Z |
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info:eu-repo/semantics/publishedVersion |
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0904-2512 |
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v. 39, n. 7 |
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0904-2512 v. 39, n. 7 |
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http://www.repositorio.ufba.br/ri/handle/ri/5675 |
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DOI: 10.1111/j.1600-0714.2010.00883.x |
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