The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil

Detalhes bibliográficos
Autor(a) principal: Araújo, Iguaracyra Barreto de Oliveira
Data de Publicação: 2006
Outros Autores: Bittencourt, Achilea Candida Lisboa, Schaer-Barbosa, Helenemarie, Martins Netto, Eduardo, Mendonça, Núbia, Foss, Hans-Dieter, Hummel, Michael, Stein, Harald
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12286
Resumo: Texto completo: acesso restrito. p.315-319
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spelling Araújo, Iguaracyra Barreto de OliveiraBittencourt, Achilea Candida LisboaSchaer-Barbosa, HelenemarieMartins Netto, EduardoMendonça, NúbiaFoss, Hans-DieterHummel, MichaelStein, HaraldAraújo, Iguaracyra Barreto de OliveiraBittencourt, Achilea Candida LisboaSchaer-Barbosa, HelenemarieMartins Netto, EduardoMendonça, NúbiaFoss, Hans-DieterHummel, MichaelStein, Harald2013-07-25T16:00:37Z20060945-6317http://www.repositorio.ufba.br/ri/handle/ri/12286v.449 n. 3Texto completo: acesso restrito. p.315-319Pediatric Hodgkin lymphoma (HL) occurring in developing regions is different from HL in industrialized countries due to the higher frequency of association with Epstein–Barr virus (EBV) infection. This infection is related to classical HL (cHL) but is virtually absent in nodular lymphocyte predominant HL (nLPHL). We studied the phenotype and the expression of EBV gene products in 90 pediatric cases by immunohistochemistry and in situ hybridization. EBV-positive tumor cells were found exclusively in cHL. The infection occurred with high frequency in all cHL subtypes, but it predominated in the mixed cellularity and lymphocyte depletion subtypes. These results reinforce the hypothesis that EBV plays a major role in the etiology of pediatric cHL in developing areas. Curiously, the frequency of EBV infection in HL was identical to the previously described for Burkitt’s lymphoma in the same pediatric population. As both lymphomas have a postulated precursor cell in the germinal center (GC), the pattern of latently EBV-infected GC cells previously described in Bahia may be related to the development of these lymphomas.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-07-25T16:00:37Z No. of bitstreams: 1 10.1007_s00428-006-0244-z.pdf: 191308 bytes, checksum: 69b77e758b9dab1554a7f5db35f376c5 (MD5)Made available in DSpace on 2013-07-25T16:00:37Z (GMT). No. of bitstreams: 1 10.1007_s00428-006-0244-z.pdf: 191308 bytes, checksum: 69b77e758b9dab1554a7f5db35f376c5 (MD5) Previous issue date: 2006http://dx.doi.org/ 10.1007/s00428-006-0244-zreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEpstein–Barr virus infectionClassical Hodgkin lymphomaNodular lymphocyte predominant Hodgkin lymphomaPediatric Hodgkin lymphomaThe high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, BrazilVirchows Archinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL10.1007_s00428-006-0244-z.pdf10.1007_s00428-006-0244-z.pdfapplication/pdf191308https://repositorio.ufba.br/bitstream/ri/12286/1/10.1007_s00428-006-0244-z.pdf69b77e758b9dab1554a7f5db35f376c5MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12286/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT10.1007_s00428-006-0244-z.pdf.txt10.1007_s00428-006-0244-z.pdf.txtExtracted texttext/plain22602https://repositorio.ufba.br/bitstream/ri/12286/3/10.1007_s00428-006-0244-z.pdf.txta010b6a2e696996f6afc8c6c3a4da340MD53ri/122862022-08-08 13:17:33.237oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:33Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil
dc.title.alternative.pt_BR.fl_str_mv Virchows Arch
title The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil
spellingShingle The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil
Araújo, Iguaracyra Barreto de Oliveira
Epstein–Barr virus infection
Classical Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma
Pediatric Hodgkin lymphoma
title_short The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil
title_full The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil
title_fullStr The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil
title_full_unstemmed The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil
title_sort The high frequency of EBV infection in pediatric Hodgkin lymphoma is related to the classical type in Bahia, Brazil
author Araújo, Iguaracyra Barreto de Oliveira
author_facet Araújo, Iguaracyra Barreto de Oliveira
Bittencourt, Achilea Candida Lisboa
Schaer-Barbosa, Helenemarie
Martins Netto, Eduardo
Mendonça, Núbia
Foss, Hans-Dieter
Hummel, Michael
Stein, Harald
author_role author
author2 Bittencourt, Achilea Candida Lisboa
Schaer-Barbosa, Helenemarie
Martins Netto, Eduardo
Mendonça, Núbia
Foss, Hans-Dieter
Hummel, Michael
Stein, Harald
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Iguaracyra Barreto de Oliveira
Bittencourt, Achilea Candida Lisboa
Schaer-Barbosa, Helenemarie
Martins Netto, Eduardo
Mendonça, Núbia
Foss, Hans-Dieter
Hummel, Michael
Stein, Harald
Araújo, Iguaracyra Barreto de Oliveira
Bittencourt, Achilea Candida Lisboa
Schaer-Barbosa, Helenemarie
Martins Netto, Eduardo
Mendonça, Núbia
Foss, Hans-Dieter
Hummel, Michael
Stein, Harald
dc.subject.por.fl_str_mv Epstein–Barr virus infection
Classical Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma
Pediatric Hodgkin lymphoma
topic Epstein–Barr virus infection
Classical Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma
Pediatric Hodgkin lymphoma
description Texto completo: acesso restrito. p.315-319
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-07-25T16:00:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12286
dc.identifier.issn.none.fl_str_mv 0945-6317
dc.identifier.number.pt_BR.fl_str_mv v.449 n. 3
identifier_str_mv 0945-6317
v.449 n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/12286
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1007/s00428-006-0244-z
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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