Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13983 |
Resumo: | p. 168-176 |
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Batista, RonanGarcía, Pablo A.Castro, María AngelesCorral, José M. Miguel delSpeziali, Nivaldo L.Varotti, Fernando de P.Paula, Renata C. deGarcía-Fernández, Luis F.Francesch, AndrésFeliciano, Arturo SanOliveira, Alaíde B. deBatista, RonanGarcía, Pablo A.Castro, María AngelesCorral, José M. Miguel delSpeziali, Nivaldo L.Varotti, Fernando de P.Paula, Renata C. deGarcía-Fernández, Luis F.Francesch, AndrésFeliciano, Arturo SanOliveira, Alaíde B. de2013-11-27T19:37:41Z20130223-5234http://repositorio.ufba.br/ri/handle/ri/13983v. 62p. 168-176This paper reports on the syntheses and spectrometric characterisation of eleven novel ent-kaurane diterpenoids, including a complete set of 1H, 13C NMR and crystallographic data for two novel entkaurane diepoxides. Moreover, the antineoplastic cytotoxicity for kaurenoic acid and the majority of entkaurane derivatives were assessed in vitro against a panel of fourteen cancer cell lines, of which allylic alcohols were shown to be the most active compounds. The good in vitro antimalarial activity and the higher selectivity index values observed for some ent-kaurane epoxides against the chloroquine-resistant W2 clone of Plasmodium falciparum indicate that this class of natural products may provide new hits for the development of antimalarial drugs.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-11-27T19:37:41Z No. of bitstreams: 1 55555555555.pdf: 528039 bytes, checksum: 10ec7dd81bfdb43c312fde4f55c162fe (MD5)Made available in DSpace on 2013-11-27T19:37:41Z (GMT). No. of bitstreams: 1 55555555555.pdf: 528039 bytes, checksum: 10ec7dd81bfdb43c312fde4f55c162fe (MD5) Previous issue date: 2013SalvadorEuropean Journal of Medicinal Chemistryhttp://www.sciencedirect.com/science/article/pii/S0223523412007325reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAWedelia paludosa D.C.Ent-Kaurane derivativesIn vitro antimalarial activityPlasmodium falciparumAntineoplastic activitySynthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivativesEuropean Journal of Medicinal Chemistryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL55555555555.pdf55555555555.pdfapplication/pdf528039https://repositorio.ufba.br/bitstream/ri/13983/1/55555555555.pdf10ec7dd81bfdb43c312fde4f55c162feMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13983/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT55555555555.pdf.txt55555555555.pdf.txtExtracted texttext/plain59367https://repositorio.ufba.br/bitstream/ri/13983/3/55555555555.pdf.txt7e6f9502ce01471ad1b30e6b104da50aMD53ri/139832022-07-05 14:03:51.585oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives |
dc.title.alternative.pt_BR.fl_str_mv |
European Journal of Medicinal Chemistry |
title |
Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives |
spellingShingle |
Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives Batista, Ronan Wedelia paludosa D.C. Ent-Kaurane derivatives In vitro antimalarial activity Plasmodium falciparum Antineoplastic activity |
title_short |
Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives |
title_full |
Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives |
title_fullStr |
Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives |
title_full_unstemmed |
Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives |
title_sort |
Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives |
author |
Batista, Ronan |
author_facet |
Batista, Ronan García, Pablo A. Castro, María Angeles Corral, José M. Miguel del Speziali, Nivaldo L. Varotti, Fernando de P. Paula, Renata C. de García-Fernández, Luis F. Francesch, Andrés Feliciano, Arturo San Oliveira, Alaíde B. de |
author_role |
author |
author2 |
García, Pablo A. Castro, María Angeles Corral, José M. Miguel del Speziali, Nivaldo L. Varotti, Fernando de P. Paula, Renata C. de García-Fernández, Luis F. Francesch, Andrés Feliciano, Arturo San Oliveira, Alaíde B. de |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Batista, Ronan García, Pablo A. Castro, María Angeles Corral, José M. Miguel del Speziali, Nivaldo L. Varotti, Fernando de P. Paula, Renata C. de García-Fernández, Luis F. Francesch, Andrés Feliciano, Arturo San Oliveira, Alaíde B. de Batista, Ronan García, Pablo A. Castro, María Angeles Corral, José M. Miguel del Speziali, Nivaldo L. Varotti, Fernando de P. Paula, Renata C. de García-Fernández, Luis F. Francesch, Andrés Feliciano, Arturo San Oliveira, Alaíde B. de |
dc.subject.por.fl_str_mv |
Wedelia paludosa D.C. Ent-Kaurane derivatives In vitro antimalarial activity Plasmodium falciparum Antineoplastic activity |
topic |
Wedelia paludosa D.C. Ent-Kaurane derivatives In vitro antimalarial activity Plasmodium falciparum Antineoplastic activity |
description |
p. 168-176 |
publishDate |
2013 |
dc.date.accessioned.fl_str_mv |
2013-11-27T19:37:41Z |
dc.date.issued.fl_str_mv |
2013 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/13983 |
dc.identifier.issn.none.fl_str_mv |
0223-5234 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 62 |
identifier_str_mv |
0223-5234 v. 62 |
url |
http://repositorio.ufba.br/ri/handle/ri/13983 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
European Journal of Medicinal Chemistry |
publisher.none.fl_str_mv |
European Journal of Medicinal Chemistry |
dc.source.pt_BR.fl_str_mv |
http://www.sciencedirect.com/science/article/pii/S0223523412007325 |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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UFBA |
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Repositório Institucional da UFBA |
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Repositório Institucional da UFBA |
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