Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives

Detalhes bibliográficos
Autor(a) principal: Batista, Ronan
Data de Publicação: 2013
Outros Autores: García, Pablo A., Castro, María Angeles, Corral, José M. Miguel del, Speziali, Nivaldo L., Varotti, Fernando de P., Paula, Renata C. de, García-Fernández, Luis F., Francesch, Andrés, Feliciano, Arturo San, Oliveira, Alaíde B. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13983
Resumo: p. 168-176
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spelling Batista, RonanGarcía, Pablo A.Castro, María AngelesCorral, José M. Miguel delSpeziali, Nivaldo L.Varotti, Fernando de P.Paula, Renata C. deGarcía-Fernández, Luis F.Francesch, AndrésFeliciano, Arturo SanOliveira, Alaíde B. deBatista, RonanGarcía, Pablo A.Castro, María AngelesCorral, José M. Miguel delSpeziali, Nivaldo L.Varotti, Fernando de P.Paula, Renata C. deGarcía-Fernández, Luis F.Francesch, AndrésFeliciano, Arturo SanOliveira, Alaíde B. de2013-11-27T19:37:41Z20130223-5234http://repositorio.ufba.br/ri/handle/ri/13983v. 62p. 168-176This paper reports on the syntheses and spectrometric characterisation of eleven novel ent-kaurane diterpenoids, including a complete set of 1H, 13C NMR and crystallographic data for two novel entkaurane diepoxides. Moreover, the antineoplastic cytotoxicity for kaurenoic acid and the majority of entkaurane derivatives were assessed in vitro against a panel of fourteen cancer cell lines, of which allylic alcohols were shown to be the most active compounds. The good in vitro antimalarial activity and the higher selectivity index values observed for some ent-kaurane epoxides against the chloroquine-resistant W2 clone of Plasmodium falciparum indicate that this class of natural products may provide new hits for the development of antimalarial drugs.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-11-27T19:37:41Z No. of bitstreams: 1 55555555555.pdf: 528039 bytes, checksum: 10ec7dd81bfdb43c312fde4f55c162fe (MD5)Made available in DSpace on 2013-11-27T19:37:41Z (GMT). No. of bitstreams: 1 55555555555.pdf: 528039 bytes, checksum: 10ec7dd81bfdb43c312fde4f55c162fe (MD5) Previous issue date: 2013SalvadorEuropean Journal of Medicinal Chemistryhttp://www.sciencedirect.com/science/article/pii/S0223523412007325reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAWedelia paludosa D.C.Ent-Kaurane derivativesIn vitro antimalarial activityPlasmodium falciparumAntineoplastic activitySynthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivativesEuropean Journal of Medicinal Chemistryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL55555555555.pdf55555555555.pdfapplication/pdf528039https://repositorio.ufba.br/bitstream/ri/13983/1/55555555555.pdf10ec7dd81bfdb43c312fde4f55c162feMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13983/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT55555555555.pdf.txt55555555555.pdf.txtExtracted texttext/plain59367https://repositorio.ufba.br/bitstream/ri/13983/3/55555555555.pdf.txt7e6f9502ce01471ad1b30e6b104da50aMD53ri/139832022-07-05 14:03:51.585oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
dc.title.alternative.pt_BR.fl_str_mv European Journal of Medicinal Chemistry
title Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
spellingShingle Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
Batista, Ronan
Wedelia paludosa D.C.
Ent-Kaurane derivatives
In vitro antimalarial activity
Plasmodium falciparum
Antineoplastic activity
title_short Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
title_full Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
title_fullStr Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
title_full_unstemmed Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
title_sort Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
author Batista, Ronan
author_facet Batista, Ronan
García, Pablo A.
Castro, María Angeles
Corral, José M. Miguel del
Speziali, Nivaldo L.
Varotti, Fernando de P.
Paula, Renata C. de
García-Fernández, Luis F.
Francesch, Andrés
Feliciano, Arturo San
Oliveira, Alaíde B. de
author_role author
author2 García, Pablo A.
Castro, María Angeles
Corral, José M. Miguel del
Speziali, Nivaldo L.
Varotti, Fernando de P.
Paula, Renata C. de
García-Fernández, Luis F.
Francesch, Andrés
Feliciano, Arturo San
Oliveira, Alaíde B. de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Batista, Ronan
García, Pablo A.
Castro, María Angeles
Corral, José M. Miguel del
Speziali, Nivaldo L.
Varotti, Fernando de P.
Paula, Renata C. de
García-Fernández, Luis F.
Francesch, Andrés
Feliciano, Arturo San
Oliveira, Alaíde B. de
Batista, Ronan
García, Pablo A.
Castro, María Angeles
Corral, José M. Miguel del
Speziali, Nivaldo L.
Varotti, Fernando de P.
Paula, Renata C. de
García-Fernández, Luis F.
Francesch, Andrés
Feliciano, Arturo San
Oliveira, Alaíde B. de
dc.subject.por.fl_str_mv Wedelia paludosa D.C.
Ent-Kaurane derivatives
In vitro antimalarial activity
Plasmodium falciparum
Antineoplastic activity
topic Wedelia paludosa D.C.
Ent-Kaurane derivatives
In vitro antimalarial activity
Plasmodium falciparum
Antineoplastic activity
description p. 168-176
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-27T19:37:41Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.none.fl_str_mv 0223-5234
dc.identifier.number.pt_BR.fl_str_mv v. 62
identifier_str_mv 0223-5234
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url http://repositorio.ufba.br/ri/handle/ri/13983
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dc.publisher.none.fl_str_mv European Journal of Medicinal Chemistry
publisher.none.fl_str_mv European Journal of Medicinal Chemistry
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