Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals

Detalhes bibliográficos
Autor(a) principal: Oliveira, Sergio Costa
Data de Publicação: 2006
Outros Autores: Pacífico, Lucila Grossi Gonçalves, Goes, Alfredo Miranda de, Oliveira, Ricardo Riccio, Cardoso, Luciana Santos, Araujo, Maria Ilma Andrade Santos, Fonseca, Cristina Toscano, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5063
Resumo: p. 6
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spelling Oliveira, Sergio CostaPacífico, Lucila Grossi GonçalvesGoes, Alfredo Miranda deOliveira, Ricardo RiccioCardoso, Luciana SantosAraujo, Maria Ilma Andrade SantosFonseca, Cristina ToscanoCarvalho Filho, Edgar Marcelino deOliveira, Sergio CostaPacífico, Lucila Grossi GonçalvesGoes, Alfredo Miranda deOliveira, Ricardo RiccioCardoso, Luciana SantosAraujo, Maria Ilma Andrade SantosFonseca, Cristina ToscanoCarvalho Filho, Edgar Marcelino de2012-01-07T01:43:22Z2012-01-07T01:43:22Z2006-101678-8060http://www.repositorio.ufba.br/ri/handle/ri/5063v. 101.p. 6Asthmatics infected with Schistosoma mansoni have a less severe course of asthma and an inhibition of the Th2 inflammatory response that seems to be mediated by interleukin (IL-10). The objective of this study was to evaluate the capacity of some S. mansoni antigens to stimulate IL-10 production in vitro by cells of asthmatic infected individuals. Peripheral bloods mononuclear cells were stimulated with the S. mansoni recombinant antigens Sm22.6, Sm14, P24, and PIII antigen. IL-10 was measured in the supernatants of cultures. As the recombinant antigens were cloned in Escherichia coli, we blocked contaminant endotoxin with polymyxin B added to the cultures. We demonstrated that all antigens used drove high production of IL-10 in S. mansoni infected individuals (n = 13, 408 ± 514 and 401 ± 383 pg/ml, 484 ± 245 pg/ml, 579 ± 468 pg/ml, respectively). In asthmatics infected with S. mansoni (n = 21) rP24 induced higher levels of IL-10 (565 ± 377 pg/ml) when compared to PIII, rSm14 and rSm22.6 (184 ± 209 pg/ml; 292 ± 243 pg/ml; 156 ± 247 pg/ml, respectively). Conclusion: the S. mansoni antigens evaluated in this study stimulated IL-10 production by cells from infected individuals and therefore they have the potential to be used as a modulator of the inflammatory response in asthma.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-07T01:43:22Z No. of bitstreams: 1 Schistosoma mansoni antigen-driven.pdf: 217763 bytes, checksum: e119d6db58de471e43ff1ec4b42986b5 (MD5)Made available in DSpace on 2012-01-07T01:43:22Z (GMT). No. of bitstreams: 1 Schistosoma mansoni antigen-driven.pdf: 217763 bytes, checksum: e119d6db58de471e43ff1ec4b42986b5 (MD5) Previous issue date: 2006-10Schistosoma mansoni recombinant proteins - Smansoni antigens - interleukin-10Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individualsMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALSchistosoma mansoni antigen-driven.pdfSchistosoma mansoni antigen-driven.pdfapplication/pdf217763https://repositorio.ufba.br/bitstream/ri/5063/1/Schistosoma%20mansoni%20antigen-driven.pdfe119d6db58de471e43ff1ec4b42986b5MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5063/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTSchistosoma mansoni antigen-driven.pdf.txtSchistosoma mansoni antigen-driven.pdf.txtExtracted texttext/plain25191https://repositorio.ufba.br/bitstream/ri/5063/3/Schistosoma%20mansoni%20antigen-driven.pdf.txt330e1147c9a16b4488c8248bf24f4cc1MD53ri/50632022-07-05 14:03:17.239oai:repositorio.ufba.br:ri/5063VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
dc.title.alternative.pt_BR.fl_str_mv Memórias do Instituto Oswaldo Cruz
title Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
spellingShingle Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
Oliveira, Sergio Costa
Schistosoma mansoni recombinant proteins - S
mansoni antigens - interleukin-10
title_short Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
title_full Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
title_fullStr Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
title_full_unstemmed Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
title_sort Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
author Oliveira, Sergio Costa
author_facet Oliveira, Sergio Costa
Pacífico, Lucila Grossi Gonçalves
Goes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Araujo, Maria Ilma Andrade Santos
Fonseca, Cristina Toscano
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Pacífico, Lucila Grossi Gonçalves
Goes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Araujo, Maria Ilma Andrade Santos
Fonseca, Cristina Toscano
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Sergio Costa
Pacífico, Lucila Grossi Gonçalves
Goes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Araujo, Maria Ilma Andrade Santos
Fonseca, Cristina Toscano
Carvalho Filho, Edgar Marcelino de
Oliveira, Sergio Costa
Pacífico, Lucila Grossi Gonçalves
Goes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Araujo, Maria Ilma Andrade Santos
Fonseca, Cristina Toscano
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Schistosoma mansoni recombinant proteins - S
mansoni antigens - interleukin-10
topic Schistosoma mansoni recombinant proteins - S
mansoni antigens - interleukin-10
description p. 6
publishDate 2006
dc.date.issued.fl_str_mv 2006-10
dc.date.accessioned.fl_str_mv 2012-01-07T01:43:22Z
dc.date.available.fl_str_mv 2012-01-07T01:43:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5063
dc.identifier.issn.none.fl_str_mv 1678-8060
dc.identifier.number.pt_BR.fl_str_mv v. 101.
identifier_str_mv 1678-8060
v. 101.
url http://www.repositorio.ufba.br/ri/handle/ri/5063
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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