Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals

Detalhes bibliográficos
Autor(a) principal: Oliveira, Sergio Costa
Data de Publicação: 2006
Outros Autores: Pacífico, Lucila Grossi Gonçalves, Goes, Alfredo Miranda de, Oliveira, Ricardo Riccio, Cardoso, Luciana Santos, Araujo, Maria Ilma Andrade Santos, Fonseca, Cristina Toscano, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5063
Resumo: p. 6
id UFBA-2_e1d05ba17e2b4daba5b545753b6016db
oai_identifier_str oai:repositorio.ufba.br:ri/5063
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Oliveira, Sergio CostaPacífico, Lucila Grossi GonçalvesGoes, Alfredo Miranda deOliveira, Ricardo RiccioCardoso, Luciana SantosAraujo, Maria Ilma Andrade SantosFonseca, Cristina ToscanoCarvalho Filho, Edgar Marcelino deOliveira, Sergio CostaPacífico, Lucila Grossi GonçalvesGoes, Alfredo Miranda deOliveira, Ricardo RiccioCardoso, Luciana SantosAraujo, Maria Ilma Andrade SantosFonseca, Cristina ToscanoCarvalho Filho, Edgar Marcelino de2012-01-07T01:43:22Z2012-01-07T01:43:22Z2006-101678-8060http://www.repositorio.ufba.br/ri/handle/ri/5063v. 101.p. 6Asthmatics infected with Schistosoma mansoni have a less severe course of asthma and an inhibition of the Th2 inflammatory response that seems to be mediated by interleukin (IL-10). The objective of this study was to evaluate the capacity of some S. mansoni antigens to stimulate IL-10 production in vitro by cells of asthmatic infected individuals. Peripheral bloods mononuclear cells were stimulated with the S. mansoni recombinant antigens Sm22.6, Sm14, P24, and PIII antigen. IL-10 was measured in the supernatants of cultures. As the recombinant antigens were cloned in Escherichia coli, we blocked contaminant endotoxin with polymyxin B added to the cultures. We demonstrated that all antigens used drove high production of IL-10 in S. mansoni infected individuals (n = 13, 408 ± 514 and 401 ± 383 pg/ml, 484 ± 245 pg/ml, 579 ± 468 pg/ml, respectively). In asthmatics infected with S. mansoni (n = 21) rP24 induced higher levels of IL-10 (565 ± 377 pg/ml) when compared to PIII, rSm14 and rSm22.6 (184 ± 209 pg/ml; 292 ± 243 pg/ml; 156 ± 247 pg/ml, respectively). Conclusion: the S. mansoni antigens evaluated in this study stimulated IL-10 production by cells from infected individuals and therefore they have the potential to be used as a modulator of the inflammatory response in asthma.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-07T01:43:22Z No. of bitstreams: 1 Schistosoma mansoni antigen-driven.pdf: 217763 bytes, checksum: e119d6db58de471e43ff1ec4b42986b5 (MD5)Made available in DSpace on 2012-01-07T01:43:22Z (GMT). No. of bitstreams: 1 Schistosoma mansoni antigen-driven.pdf: 217763 bytes, checksum: e119d6db58de471e43ff1ec4b42986b5 (MD5) Previous issue date: 2006-10Schistosoma mansoni recombinant proteins - Smansoni antigens - interleukin-10Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individualsMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALSchistosoma mansoni antigen-driven.pdfSchistosoma mansoni antigen-driven.pdfapplication/pdf217763https://repositorio.ufba.br/bitstream/ri/5063/1/Schistosoma%20mansoni%20antigen-driven.pdfe119d6db58de471e43ff1ec4b42986b5MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5063/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTSchistosoma mansoni antigen-driven.pdf.txtSchistosoma mansoni antigen-driven.pdf.txtExtracted texttext/plain25191https://repositorio.ufba.br/bitstream/ri/5063/3/Schistosoma%20mansoni%20antigen-driven.pdf.txt330e1147c9a16b4488c8248bf24f4cc1MD53ri/50632022-07-05 14:03:17.239oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
dc.title.alternative.pt_BR.fl_str_mv Memórias do Instituto Oswaldo Cruz
title Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
spellingShingle Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
Oliveira, Sergio Costa
Schistosoma mansoni recombinant proteins - S
mansoni antigens - interleukin-10
title_short Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
title_full Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
title_fullStr Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
title_full_unstemmed Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
title_sort Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
author Oliveira, Sergio Costa
author_facet Oliveira, Sergio Costa
Pacífico, Lucila Grossi Gonçalves
Goes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Araujo, Maria Ilma Andrade Santos
Fonseca, Cristina Toscano
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Pacífico, Lucila Grossi Gonçalves
Goes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Araujo, Maria Ilma Andrade Santos
Fonseca, Cristina Toscano
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Sergio Costa
Pacífico, Lucila Grossi Gonçalves
Goes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Araujo, Maria Ilma Andrade Santos
Fonseca, Cristina Toscano
Carvalho Filho, Edgar Marcelino de
Oliveira, Sergio Costa
Pacífico, Lucila Grossi Gonçalves
Goes, Alfredo Miranda de
Oliveira, Ricardo Riccio
Cardoso, Luciana Santos
Araujo, Maria Ilma Andrade Santos
Fonseca, Cristina Toscano
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Schistosoma mansoni recombinant proteins - S
mansoni antigens - interleukin-10
topic Schistosoma mansoni recombinant proteins - S
mansoni antigens - interleukin-10
description p. 6
publishDate 2006
dc.date.issued.fl_str_mv 2006-10
dc.date.accessioned.fl_str_mv 2012-01-07T01:43:22Z
dc.date.available.fl_str_mv 2012-01-07T01:43:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5063
dc.identifier.issn.none.fl_str_mv 1678-8060
dc.identifier.number.pt_BR.fl_str_mv v. 101.
identifier_str_mv 1678-8060
v. 101.
url http://www.repositorio.ufba.br/ri/handle/ri/5063
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/5063/1/Schistosoma%20mansoni%20antigen-driven.pdf
https://repositorio.ufba.br/bitstream/ri/5063/2/license.txt
https://repositorio.ufba.br/bitstream/ri/5063/3/Schistosoma%20mansoni%20antigen-driven.pdf.txt
bitstream.checksum.fl_str_mv e119d6db58de471e43ff1ec4b42986b5
1b89a9a0548218172d7c829f87a0eab9
330e1147c9a16b4488c8248bf24f4cc1
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459391676973056

Registros relacionados