Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Homero Gustavo Correia
Data de Publicação: 2013
Outros Autores: Pontes, Alana Abrantes Nogueira De, Adan, Luís Fernando Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15045
Resumo: Texto completo: acesso restrito. p. 191-196
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spelling Rodrigues, Homero Gustavo CorreiaPontes, Alana Abrantes Nogueira DeAdan, Luís Fernando FernandesRodrigues, Homero Gustavo CorreiaPontes, Alana Abrantes Nogueira DeAdan, Luís Fernando Fernandes2014-06-04T16:18:52Z20131792-1074http://repositorio.ufba.br/ri/handle/ri/15045v. 6, n. 1Texto completo: acesso restrito. p. 191-196Numerous experiments have been conducted over the last few years aiming to identify molecular markers that show the diagnostic accuracy of fine‑needle aspiration (FNA), particularly in thyroid lesions that are considered indeterminate. Using certain search arguments and previously defined criteria, 37 studies reporting experiments with the BRAF mutation in pre‑operative FNA of the thyroid were selected from the electronic databases PUBMED, MEDLINE, SCOPUS and LILACS, in order to gather evidence with regard to the possible contribution of BRAF in the management of thyroid carcinoma. There were no cases positive for BRAF in follicular carcinomas (FTCs), Hürthle cell carcinomas (HCCs) or medullary thyroid carcinomas (MTCs). Among the 11 cases of anaplastic thyroid carcinomas (ATC), three showed positive results for the BRAF mutation. The number of cases positive for BRAF among the benign lesions was not significant. The average prevalence of BRAF‑positive cases in papillary carcinomas (PTC) was 58.6%, while in follicular variants of papillary carcinoma (FVPTC), the average prevalence was 29.6%. For lesions diagnosed as indeterminate or suspicious, the average prevalence of BRAF positivity in PTC was 48.5%. The experiments included in the present study indicated a specificity of almost 100% and a high predominance of the BRAF mutation in PTC, distinguishing the marker in the planning and medical management of papillary carcinoma of the thyroid.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-20T14:19:08Z No. of bitstreams: 1 10.3892-ol.2013.1359.pdf: 318221 bytes, checksum: 7593a43009f189b1958d769f3a374ff3 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-04T16:18:52Z (GMT) No. of bitstreams: 1 10.3892-ol.2013.1359.pdf: 318221 bytes, checksum: 7593a43009f189b1958d769f3a374ff3 (MD5)Made available in DSpace on 2014-06-04T16:18:52Z (GMT). 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dc.title.pt_BR.fl_str_mv Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
dc.title.alternative.pt_BR.fl_str_mv Oncology Letters
title Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
spellingShingle Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
Rodrigues, Homero Gustavo Correia
Fine‑needle aspiration
BRAF mutation
Papillary thyroid carcinoma
Oncogenes
Carcinoma
Thyroid Gland
title_short Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
title_full Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
title_fullStr Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
title_full_unstemmed Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
title_sort Contribution of the BRAF oncogene in the pre‑operative phase of thyroid carcinoma
author Rodrigues, Homero Gustavo Correia
author_facet Rodrigues, Homero Gustavo Correia
Pontes, Alana Abrantes Nogueira De
Adan, Luís Fernando Fernandes
author_role author
author2 Pontes, Alana Abrantes Nogueira De
Adan, Luís Fernando Fernandes
author2_role author
author
dc.contributor.author.fl_str_mv Rodrigues, Homero Gustavo Correia
Pontes, Alana Abrantes Nogueira De
Adan, Luís Fernando Fernandes
Rodrigues, Homero Gustavo Correia
Pontes, Alana Abrantes Nogueira De
Adan, Luís Fernando Fernandes
dc.subject.por.fl_str_mv Fine‑needle aspiration
BRAF mutation
Papillary thyroid carcinoma
Oncogenes
Carcinoma
Thyroid Gland
topic Fine‑needle aspiration
BRAF mutation
Papillary thyroid carcinoma
Oncogenes
Carcinoma
Thyroid Gland
description Texto completo: acesso restrito. p. 191-196
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-06-04T16:18:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15045
dc.identifier.issn.none.fl_str_mv 1792-1074
dc.identifier.number.pt_BR.fl_str_mv v. 6, n. 1
identifier_str_mv 1792-1074
v. 6, n. 1
url http://repositorio.ufba.br/ri/handle/ri/15045
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.3892/ol.2013.1359
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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