Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans

Detalhes bibliográficos
Autor(a) principal: Athanazio, Daniel Abensur
Data de Publicação: 2008
Outros Autores: Santos, Cleiton S., Santos, Andréia C., McBride, Flávia W.C., Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6427
Resumo: Acesso restrito: Texto completo. p. 95-98.
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spelling Athanazio, Daniel AbensurSantos, Cleiton S.Santos, Andréia C.McBride, Flávia W.C.Reis, Mitermayer Galvão dosAthanazio, Daniel AbensurSantos, Cleiton S.Santos, Andréia C.McBride, Flávia W.C.Reis, Mitermayer Galvão dos2012-07-13T15:25:08Z20080001-706Xhttp://www.repositorio.ufba.br/ri/handle/ri/6427v. 105, n. 2Acesso restrito: Texto completo. p. 95-98.Only recently, knockout mouse models were applied in studies on the pathogenesis of leptospirosis. Current data suggest an important role of innate immunity receptors and interferon dependant cellular response on protection. It is not clear, however, whether T helper cell polarization influences on outcome of leptospiral infection. We report findings of experimental infection of C57BL/6 (interferon or tumor necrosis factor receptor deficient) and BALB/c (interleukin 4 deficient) mice infected by pathogenic Leptospira interrogans serovar Copenhageni. Specific cytokine gene deficiency had no impact on outcome since all animals survived. TNFR knockout mice, however, exhibited more severe residual renal inflammation during convalescence thus suggesting this cytokine is important in early control of infection, protecting kidneys from relevant pathology.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-07-13T15:25:08Z No. of bitstreams: 1 __ac.els-cdn.com_S000170...be2dca512abf73dd124862e093c95.pdf: 191215 bytes, checksum: ca5a775f6f3eec345851974e797025f5 (MD5)Made available in DSpace on 2012-07-13T15:25:08Z (GMT). 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dc.title.pt_BR.fl_str_mv Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
dc.title.alternative.pt_BR.fl_str_mv ACTA Tropica
title Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
spellingShingle Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
Athanazio, Daniel Abensur
Leptospirosis
Leptospira
Mice
Knockout
Cytokines
Animal disease models
title_short Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
title_full Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
title_fullStr Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
title_full_unstemmed Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
title_sort Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans
author Athanazio, Daniel Abensur
author_facet Athanazio, Daniel Abensur
Santos, Cleiton S.
Santos, Andréia C.
McBride, Flávia W.C.
Reis, Mitermayer Galvão dos
author_role author
author2 Santos, Cleiton S.
Santos, Andréia C.
McBride, Flávia W.C.
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Athanazio, Daniel Abensur
Santos, Cleiton S.
Santos, Andréia C.
McBride, Flávia W.C.
Reis, Mitermayer Galvão dos
Athanazio, Daniel Abensur
Santos, Cleiton S.
Santos, Andréia C.
McBride, Flávia W.C.
Reis, Mitermayer Galvão dos
dc.subject.por.fl_str_mv Leptospirosis
Leptospira
Mice
Knockout
Cytokines
Animal disease models
topic Leptospirosis
Leptospira
Mice
Knockout
Cytokines
Animal disease models
description Acesso restrito: Texto completo. p. 95-98.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-07-13T15:25:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6427
dc.identifier.issn.none.fl_str_mv 0001-706X
dc.identifier.number.pt_BR.fl_str_mv v. 105, n. 2
identifier_str_mv 0001-706X
v. 105, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/6427
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.actatropica.2007.09.004
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
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