Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans

Detalhes bibliográficos
Autor(a) principal: Athanazio, Daniel Abensur
Data de Publicação: 2008
Outros Autores: Silva, Everton F., Santos, Cleiton S., Rocha, Gustavo M., Vannier-Santos, Marcos André, McBride, Alan J. A., Ko, Albert I., Reis, Mitermayer G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6403
Resumo: Acesso restrito: Texto completo. p. 176-180.
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spelling Athanazio, Daniel AbensurSilva, Everton F.Santos, Cleiton S.Rocha, Gustavo M.Vannier-Santos, Marcos AndréMcBride, Alan J. A.Ko, Albert I.Reis, Mitermayer G.Athanazio, Daniel AbensurSilva, Everton F.Santos, Cleiton S.Rocha, Gustavo M.Vannier-Santos, Marcos AndréMcBride, Alan J. A.Ko, Albert I.Reis, Mitermayer G.2012-07-11T14:04:43Z20080001-706Xhttp://www.repositorio.ufba.br/ri/handle/ri/6403v. 105, n. 2Acesso restrito: Texto completo. p. 176-180.Leptospirosis continues to be a disease with a poorly understood pathogenesis. The experimental rat model is amenable for the investigation of leptospiral dissemination, tropism, persistence of renal colonization and factors related to disease resistance. In this study,Wistar rats were infected intraperitoneally with virulent Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130. The detection of leptospires in tissue samples was based on culture, silver staining and immunofluorescence techniques. An inoculum of 10,000 leptospires induced colonization in 50% of rats and colonization persisted for the 4-month period of the study. Dissemination kinetics revealed that renal colonization took place 7–9 days after infection, with no underlying histopathology. The peak leptospiral load occurred on day 5 post-infection, followed by rapid clearance in all tissues except the kidneys, where dense leptospiral aggregates persisted in the renal tubules. We conclude that the experimental rat model is suitable for studies contributing towards the understanding of the mechanisms of colonization and resistance to severe disease in leptospirosis.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-07-11T14:04:43Z No. of bitstreams: 1 CONFIG~1....0-S0001706X0700263X-main.pdf: 216761 bytes, checksum: 5b95edc9fa0073a1af4d6293da080f6a (MD5)Made available in DSpace on 2012-07-11T14:04:43Z (GMT). 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dc.title.pt_BR.fl_str_mv Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans
dc.title.alternative.pt_BR.fl_str_mv ACTA Tropica
title Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans
spellingShingle Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans
Athanazio, Daniel Abensur
Leptospirosis
Leptospira
Rats
Animal disease models
title_short Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans
title_full Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans
title_fullStr Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans
title_full_unstemmed Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans
title_sort Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans
author Athanazio, Daniel Abensur
author_facet Athanazio, Daniel Abensur
Silva, Everton F.
Santos, Cleiton S.
Rocha, Gustavo M.
Vannier-Santos, Marcos André
McBride, Alan J. A.
Ko, Albert I.
Reis, Mitermayer G.
author_role author
author2 Silva, Everton F.
Santos, Cleiton S.
Rocha, Gustavo M.
Vannier-Santos, Marcos André
McBride, Alan J. A.
Ko, Albert I.
Reis, Mitermayer G.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Athanazio, Daniel Abensur
Silva, Everton F.
Santos, Cleiton S.
Rocha, Gustavo M.
Vannier-Santos, Marcos André
McBride, Alan J. A.
Ko, Albert I.
Reis, Mitermayer G.
Athanazio, Daniel Abensur
Silva, Everton F.
Santos, Cleiton S.
Rocha, Gustavo M.
Vannier-Santos, Marcos André
McBride, Alan J. A.
Ko, Albert I.
Reis, Mitermayer G.
dc.subject.por.fl_str_mv Leptospirosis
Leptospira
Rats
Animal disease models
topic Leptospirosis
Leptospira
Rats
Animal disease models
description Acesso restrito: Texto completo. p. 176-180.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-07-11T14:04:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6403
dc.identifier.issn.none.fl_str_mv 0001-706X
dc.identifier.number.pt_BR.fl_str_mv v. 105, n. 2
identifier_str_mv 0001-706X
v. 105, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/6403
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.actatropica.2007.10.012,
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