Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder

Detalhes bibliográficos
Autor(a) principal: Chacon, Priscila
Data de Publicação: 2007
Outros Autores: Campos, Maria Conceição do Rosário, Pauls, David L., Hounie, Ana Gabriela, Curi, Mariana, Akkerman, Fernando, Shimabokuro, Fabiana Harumi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15988
Resumo: Texto completo: acesso restrito. p. 551-555
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spelling Chacon, PriscilaCampos, Maria Conceição do RosárioPauls, David L.Hounie, Ana GabrielaCuri, MarianaAkkerman, FernandoShimabokuro, Fabiana HarumiChacon, PriscilaCampos, Maria Conceição do RosárioPauls, David L.Hounie, Ana GabrielaCuri, MarianaAkkerman, FernandoShimabokuro, Fabiana Harumi2014-09-09T16:03:31Z20071552-4841http://repositorio.ufba.br/ri/handle/ri/15988v. 144, n. 4Texto completo: acesso restrito. p. 551-555Obsessive–compulsive disorder (OCD) is a heterogeneous disorder of unknown etiology. Phenotypic studies of affected sib-pairs (SPs) may help to characterize familial components of the phenotype. To determine whether SPs affected with OCD are similar in age at onset of obsessive–compulsive symptoms (OCS), symptom dimensions and presence of tic disorders (TDs). Forty OCD siblings ranging from 13 to 59 years old were evaluated by expert psychiatrists or psychologists. Families with two or more siblings affected with OCD were recruited from several OCD clinics in Brazil. The Yale Brown Obsessive–Compulsive Scale Checklist was used to assess OCS and the severity of OCD. The OCD diagnoses were made according to the DSM-IV. The chi-square test was used to assess concordance of TD presence within SPs based on the TD frequency reported in the literature (30%). There were significantly more siblings with early-onset OCS than with late-onset OCS (P = 0.002). Age at onset of OCS correlated positively and significantly between the two members of each SP (P = 0.005). Fourteen patients (35%) were diagnosed with TDs. There was no concordance of the TD presence within the SPs. When both were male, there was a significant sibling correlation in the contamination obsessions/cleaning compulsions dimension (ICC = 0.74; P = 0.002). Similarly, when both siblings were female, they were comparable in the hoarding obsessions/compulsions dimension (ICC = 0.76; P = 0.01). Familial factors seem to contribute to specific OCD phenotypic components such as age at onset of OCS and specific dimensions. The obvious influence of gender is as yet unexplained.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-24T12:57:09Z No. of bitstreams: 1 10.1002-ajmg.b.30457.pdf: 71085 bytes, checksum: 1cbb2079afbc4f5148e6e6279298f6a4 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:03:31Z (GMT) No. of bitstreams: 1 10.1002-ajmg.b.30457.pdf: 71085 bytes, checksum: 1cbb2079afbc4f5148e6e6279298f6a4 (MD5)Made available in DSpace on 2014-09-09T16:03:31Z (GMT). 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dc.title.pt_BR.fl_str_mv Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
dc.title.alternative.pt_BR.fl_str_mv American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
title Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
spellingShingle Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
Chacon, Priscila
Obsessive
Factors
Age at onset
Gender
title_short Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
title_full Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
title_fullStr Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
title_full_unstemmed Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
title_sort Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
author Chacon, Priscila
author_facet Chacon, Priscila
Campos, Maria Conceição do Rosário
Pauls, David L.
Hounie, Ana Gabriela
Curi, Mariana
Akkerman, Fernando
Shimabokuro, Fabiana Harumi
author_role author
author2 Campos, Maria Conceição do Rosário
Pauls, David L.
Hounie, Ana Gabriela
Curi, Mariana
Akkerman, Fernando
Shimabokuro, Fabiana Harumi
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chacon, Priscila
Campos, Maria Conceição do Rosário
Pauls, David L.
Hounie, Ana Gabriela
Curi, Mariana
Akkerman, Fernando
Shimabokuro, Fabiana Harumi
Chacon, Priscila
Campos, Maria Conceição do Rosário
Pauls, David L.
Hounie, Ana Gabriela
Curi, Mariana
Akkerman, Fernando
Shimabokuro, Fabiana Harumi
dc.subject.por.fl_str_mv Obsessive
Factors
Age at onset
Gender
topic Obsessive
Factors
Age at onset
Gender
description Texto completo: acesso restrito. p. 551-555
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-09-09T16:03:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15988
dc.identifier.issn.none.fl_str_mv 1552-4841
dc.identifier.number.pt_BR.fl_str_mv v. 144, n. 4
identifier_str_mv 1552-4841
v. 144, n. 4
url http://repositorio.ufba.br/ri/handle/ri/15988
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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