Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis

Detalhes bibliográficos
Autor(a) principal: Newlove, Tracey
Data de Publicação: 2011
Outros Autores: Guimarães, Luiz H., Morgan, Daniel J., Alcântara, Leda Maria, Glesby, Marshall J., Carvalho Filho, Edgar Marcelino de, Machado, Paulo Roberto Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14813
Resumo: Texto completo: acesso restrito. p. 551-555
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spelling Newlove, TraceyGuimarães, Luiz H.Morgan, Daniel J.Alcântara, Leda MariaGlesby, Marshall J.Carvalho Filho, Edgar Marcelino deMachado, Paulo Roberto LimaNewlove, TraceyGuimarães, Luiz H.Morgan, Daniel J.Alcântara, Leda MariaGlesby, Marshall J.Carvalho Filho, Edgar Marcelino deMachado, Paulo Roberto Lima2014-04-09T13:54:27Z20110002-9637http://repositorio.ufba.br/ri/handle/ri/14813v. 84, n. 4Texto completo: acesso restrito. p. 551-555Helminth infections influence the clinical response to certain diseases and are associated with delayed healing time of patients with cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. We conducted a randomized, double-blind, placebo-controlled clinical trial to examine the role of early versus deferred treatment of intestinal helminth infection on the clinical course of patients with CL treated with pentavalent antimony. (Clinicaltrials.gov number NCT00469495). A total of 90 patients were enrolled, 51.1% (N = 23) of control patients had persistent lesions at Day 90, compared with 62.2% (N = 28) in the treatment group (difference 11.1%, 95% confidence interval = −9.1–30.0%). There was no statistically significant difference in overall time to cure between groups, although there was a tendency for shorter cure times in the control group. This study shows that early introduction of antihelminthic therapy does not improve clinical outcome in patients co-infected with helminths and L. braziliensis.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-03T11:36:21Z No. of bitstreams: 1 Daniel J. Morgan.pdf: 505938 bytes, checksum: 242cdb0bf1bcc5ceba9f13dff780f82e (MD5)Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-03T11:36:21Z No. of bitstreams: 1 Daniel J. Morgan.pdf: 505938 bytes, checksum: 242cdb0bf1bcc5ceba9f13dff780f82e (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-04-09T13:54:27Z (GMT) No. of bitstreams: 1 Daniel J. Morgan.pdf: 505938 bytes, checksum: 242cdb0bf1bcc5ceba9f13dff780f82e (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-04-09T13:54:27Z (GMT) No. of bitstreams: 1 Daniel J. Morgan.pdf: 505938 bytes, checksum: 242cdb0bf1bcc5ceba9f13dff780f82e (MD5)Made available in DSpace on 2014-04-09T13:54:27Z (GMT). No. of bitstreams: 1 Daniel J. Morgan.pdf: 505938 bytes, checksum: 242cdb0bf1bcc5ceba9f13dff780f82e (MD5) Previous issue date: 2011Made available in DSpace on 2014-04-09T13:54:27Z (GMT). No. of bitstreams: 1 Daniel J. Morgan.pdf: 505938 bytes, checksum: 242cdb0bf1bcc5ceba9f13dff780f82e (MD5) Previous issue date: 2011http://dx.doi.org/ 10.4269/ajtmh.2011.10-0423reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHelminthiasisLeishmaniasis, CutaneousInfectionAntihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensisAmerican Journal of Tropical Medicine and Hygieneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALDaniel J. Morgan.pdfDaniel J. Morgan.pdfapplication/pdf505938https://repositorio.ufba.br/bitstream/ri/14813/1/Daniel%20J.%20Morgan.pdf242cdb0bf1bcc5ceba9f13dff780f82eMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14813/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTDaniel J. Morgan.pdf.txtDaniel J. 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dc.title.pt_BR.fl_str_mv Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
dc.title.alternative.pt_BR.fl_str_mv American Journal of Tropical Medicine and Hygiene
title Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
spellingShingle Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
Newlove, Tracey
Helminthiasis
Leishmaniasis, Cutaneous
Infection
title_short Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
title_full Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
title_fullStr Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
title_full_unstemmed Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
title_sort Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
author Newlove, Tracey
author_facet Newlove, Tracey
Guimarães, Luiz H.
Morgan, Daniel J.
Alcântara, Leda Maria
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
Machado, Paulo Roberto Lima
author_role author
author2 Guimarães, Luiz H.
Morgan, Daniel J.
Alcântara, Leda Maria
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
Machado, Paulo Roberto Lima
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Newlove, Tracey
Guimarães, Luiz H.
Morgan, Daniel J.
Alcântara, Leda Maria
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
Machado, Paulo Roberto Lima
Newlove, Tracey
Guimarães, Luiz H.
Morgan, Daniel J.
Alcântara, Leda Maria
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
Machado, Paulo Roberto Lima
dc.subject.por.fl_str_mv Helminthiasis
Leishmaniasis, Cutaneous
Infection
topic Helminthiasis
Leishmaniasis, Cutaneous
Infection
description Texto completo: acesso restrito. p. 551-555
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-04-09T13:54:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14813
dc.identifier.issn.none.fl_str_mv 0002-9637
dc.identifier.number.pt_BR.fl_str_mv v. 84, n. 4
identifier_str_mv 0002-9637
v. 84, n. 4
url http://repositorio.ufba.br/ri/handle/ri/14813
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.4269/ajtmh.2011.10-0423
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