Thalidomide induces mucosal healing in Crohn's disease: Case report

Detalhes bibliográficos
Autor(a) principal: Leite, Márcio Rios
Data de Publicação: 2011
Outros Autores: Santos, Sandra Sousa, Lyra, André Castro, Mota, Jaciane, Santana, Genoile Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16448
Resumo: p. 5028-5031
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spelling Leite, Márcio RiosSantos, Sandra SousaLyra, André CastroMota, JacianeSantana, Genoile OliveiraLeite, Márcio RiosSantos, Sandra SousaLyra, André CastroMota, JacianeSantana, Genoile Oliveira2014-10-21T16:47:01Z2014-10-21T16:47:01Z20111007-9327http://repositorio.ufba.br/ri/handle/ri/16448v. 17 n. 45p. 5028-5031Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract that is defined by relapsing and remitting episodes. Tumor necrosis factor alpha (TNF-α) appears to play a central role in the pathophysiology of the disease. Standard therapies for inflammatory bowel disease fail to induce remission in about 30% of patients. Biological therapies have been associated with an increased incidence of infections, especially infection by Mycobacterium tuberculosis (Mtb). Thalidomide is an oral immunomodulatory agent with anti-TNF-α properties. Recent studies have suggested that thalidomide is effective in refractory luminal and fistulizing Crohn’s disease. Thalidomide costimulates T lymphocytes, with greater effect on CD8+ than on CD4+ T cells, which contributes to the protective immune response to Mtb infection. We present a case of Crohn’s disease with gastric, ileal, colon and rectum involvement as well as steroid dependency, which progressed with loss of response to infliximab after three years of therapy. The thorax computed tomography scan demonstrated a pulmonary nodule suspected to be Mtb infection. The patient was started on thalidomide therapy and exhibited an excellent response.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-02-13T15:04:32Z No. of bitstreams: 1 André Castro Lyra.pdf: 762804 bytes, checksum: 62361fef0df59145c8b13ad3b56ff5ba (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-10-21T16:47:01Z (GMT) No. of bitstreams: 1 André Castro Lyra.pdf: 762804 bytes, checksum: 62361fef0df59145c8b13ad3b56ff5ba (MD5)Made available in DSpace on 2014-10-21T16:47:01Z (GMT). No. of bitstreams: 1 André Castro Lyra.pdf: 762804 bytes, checksum: 62361fef0df59145c8b13ad3b56ff5ba (MD5) Previous issue date: 2011http://dx.doi.org/ 10.3748/wjg.v17.i45.5028reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAnti-tumor necrosis factor alphaCrohn’s diseaseMucosal healingMycobacterium tuberculosisThalidomideThalidomide induces mucosal healing in Crohn's disease: Case reportWorld Journal of Gastroenterologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINALAndré Castro Lyra.pdfAndré Castro Lyra.pdfapplication/pdf762804https://repositorio.ufba.br/bitstream/ri/16448/1/Andr%c3%a9%20Castro%20Lyra.pdf62361fef0df59145c8b13ad3b56ff5baMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16448/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTAndré Castro Lyra.pdf.txtAndré Castro Lyra.pdf.txtExtracted texttext/plain19897https://repositorio.ufba.br/bitstream/ri/16448/3/Andr%c3%a9%20Castro%20Lyra.pdf.txt50213d272ec7af9c479ad94a4f53fd57MD53ri/164482022-08-08 13:18:25.836oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:18:25Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Thalidomide induces mucosal healing in Crohn's disease: Case report
dc.title.alternative.pt_BR.fl_str_mv World Journal of Gastroenterology
title Thalidomide induces mucosal healing in Crohn's disease: Case report
spellingShingle Thalidomide induces mucosal healing in Crohn's disease: Case report
Leite, Márcio Rios
Anti-tumor necrosis factor alpha
Crohn’s disease
Mucosal healing
Mycobacterium tuberculosis
Thalidomide
title_short Thalidomide induces mucosal healing in Crohn's disease: Case report
title_full Thalidomide induces mucosal healing in Crohn's disease: Case report
title_fullStr Thalidomide induces mucosal healing in Crohn's disease: Case report
title_full_unstemmed Thalidomide induces mucosal healing in Crohn's disease: Case report
title_sort Thalidomide induces mucosal healing in Crohn's disease: Case report
author Leite, Márcio Rios
author_facet Leite, Márcio Rios
Santos, Sandra Sousa
Lyra, André Castro
Mota, Jaciane
Santana, Genoile Oliveira
author_role author
author2 Santos, Sandra Sousa
Lyra, André Castro
Mota, Jaciane
Santana, Genoile Oliveira
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Leite, Márcio Rios
Santos, Sandra Sousa
Lyra, André Castro
Mota, Jaciane
Santana, Genoile Oliveira
Leite, Márcio Rios
Santos, Sandra Sousa
Lyra, André Castro
Mota, Jaciane
Santana, Genoile Oliveira
dc.subject.por.fl_str_mv Anti-tumor necrosis factor alpha
Crohn’s disease
Mucosal healing
Mycobacterium tuberculosis
Thalidomide
topic Anti-tumor necrosis factor alpha
Crohn’s disease
Mucosal healing
Mycobacterium tuberculosis
Thalidomide
description p. 5028-5031
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-10-21T16:47:01Z
dc.date.available.fl_str_mv 2014-10-21T16:47:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16448
dc.identifier.issn.none.fl_str_mv 1007-9327
dc.identifier.number.pt_BR.fl_str_mv v. 17 n. 45
identifier_str_mv 1007-9327
v. 17 n. 45
url http://repositorio.ufba.br/ri/handle/ri/16448
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.3748/wjg.v17.i45.5028
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
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