Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16365 |
Resumo: | Texto completo: acesso restrito. p. 611–618 |
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Arellano, I.Cestari, Tania FerreiraCandiani, J. OcampoAbulafia, L. AzulayTrindade Neto, Pedro Bezerra daHexsel, Doris MariaPinto, J. MachadoMuñoz, H.Machado, Maria Cecilia da Matta RivittiSittart, José Alexandre de SouzaAlmeida, A. R. Trindade deRego, V.Paliargues, F.Hassun, K. MarquesArellano, I.Cestari, Tania FerreiraCandiani, J. OcampoAbulafia, L. AzulayTrindade Neto, Pedro Bezerra daHexsel, Doris MariaPinto, J. MachadoMuñoz, H.Machado, Maria Cecilia da Matta RivittiSittart, José Alexandre de SouzaAlmeida, A. R. Trindade deRego, V.Paliargues, F.Hassun, K. Marques2014-10-09T16:09:03Z20120926-9959http://repositorio.ufba.br/ri/handle/ri/16365v. 26, n. 5Texto completo: acesso restrito. p. 611–618Background The relapsing nature of melasma emphasizes the need to maintain efficacy achieved after acute treatment. Objective To compare clinical efficacy and safety of two 6-month Triple Combination (TC; containing fluocinolone acetonide, hydroquinone and tretinoin) maintenance regimens in subjects with moderate to severe melasma, after daily treatment up to 8 weeks. Methods This randomized, investigator-blinded, controlled study had a maintenance phase of 6 months. Sixteen centres in Brazil and Mexico enrolled 242 subjects 18 years or older attaining no or mild melasma after 8 weeks of daily TC applications. Subjects were randomized to receive TC in a twice weekly or tapering regimen [3/week (1st month), 2/week (2nd month), 1/week (4th month)]. Efficacy and safety measurements included median time to relapse and relapse-free rate, Global Severity Score, Melasma Area and Severity Index score (MASI), subject’s assessment, quality of life questionnaire (MelasQol), and adverse events. Results The majority (78.8%) had no or mild melasma (GSS ≤ 1) at week 8 and entered maintenance phase. After 6 months, 53% of patients remained relapse-free with improved quality of life, and time to relapse was similar between groups (about 190 days). Melasma severity at study entry, not maintenance baseline, influenced relapse rate. The twice weekly regimen tended to show better effectiveness in postponing relapse in severe melasma. Both regimens were safe. Conclusions After resolution of melasma with TC, maintenance therapy over 6 months was successful in preventing relapse in over half of the patients who entered maintenance phase. Prescribing medicines should be adapted to patients based on melasma severity.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-11T14:19:34Z No. of bitstreams: 1 V. Rego.pdf: 524299 bytes, checksum: ebaf1d816cad38d17afebe4f1fd47f81 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-10-09T16:09:03Z (GMT) No. of bitstreams: 1 V. 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| dc.title.pt_BR.fl_str_mv |
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of the European Academy of Dermatology and Venereology |
| title |
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity |
| spellingShingle |
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity Arellano, I. |
| title_short |
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity |
| title_full |
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity |
| title_fullStr |
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity |
| title_full_unstemmed |
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity |
| title_sort |
Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity |
| author |
Arellano, I. |
| author_facet |
Arellano, I. Cestari, Tania Ferreira Candiani, J. Ocampo Abulafia, L. Azulay Trindade Neto, Pedro Bezerra da Hexsel, Doris Maria Pinto, J. Machado Muñoz, H. Machado, Maria Cecilia da Matta Rivitti Sittart, José Alexandre de Souza Almeida, A. R. Trindade de Rego, V. Paliargues, F. Hassun, K. Marques |
| author_role |
author |
| author2 |
Cestari, Tania Ferreira Candiani, J. Ocampo Abulafia, L. Azulay Trindade Neto, Pedro Bezerra da Hexsel, Doris Maria Pinto, J. Machado Muñoz, H. Machado, Maria Cecilia da Matta Rivitti Sittart, José Alexandre de Souza Almeida, A. R. Trindade de Rego, V. Paliargues, F. Hassun, K. Marques |
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author author author author author author author author author author author author author |
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Arellano, I. Cestari, Tania Ferreira Candiani, J. Ocampo Abulafia, L. Azulay Trindade Neto, Pedro Bezerra da Hexsel, Doris Maria Pinto, J. Machado Muñoz, H. Machado, Maria Cecilia da Matta Rivitti Sittart, José Alexandre de Souza Almeida, A. R. Trindade de Rego, V. Paliargues, F. Hassun, K. Marques Arellano, I. Cestari, Tania Ferreira Candiani, J. Ocampo Abulafia, L. Azulay Trindade Neto, Pedro Bezerra da Hexsel, Doris Maria Pinto, J. Machado Muñoz, H. Machado, Maria Cecilia da Matta Rivitti Sittart, José Alexandre de Souza Almeida, A. R. Trindade de Rego, V. Paliargues, F. Hassun, K. Marques |
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Texto completo: acesso restrito. p. 611–618 |
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2012 |
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2012 |
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v. 26, n. 5 |
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