French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/jdv.16896 http://hdl.handle.net/11449/206565 |
Resumo: | Background: Melasma can be recalcitrant to treatment, and relapses are common. Pycnogenol has been reported to be effective in treating melasma. Objective: To compare the efficacy, safety and tolerability of 75 mg pycnogenol taken orally twice a day vs. a placebo, in association with the triple combination and broad-spectrum sunscreen for the treatment of facial melasma. Methods: A randomized, double-blind, parallel, placebo-controlled study was conducted on 44 women with facial melasma in a single centre from May 2019 through November 2019. Patients with melasma were randomly assigned to orally take 75 mg pycnogenol (PYC) or a placebo (PLAC) twice a day for 60 days. Both groups also received tinted sunscreen [Sun Protection Factor (SPF) 50; Persistent Pigment Darkening (PPD) 17] for daytime use and a topical triple combination at bedtime. The primary outcome was a change from the baseline Modified Melasma Area Severity Index (mMASI) score. Secondary outcomes were improvements in the patients' quality of life (MELASQoL), colorimetric indices and Global Aesthetic Improvement Scale (GAIS). Results: All participants completed the trial. The mean (SD) age of the participants was 39 (7) years, and 91% were phototypes III–IV. Both groups exhibited a reduction in mMASI scores, MELASQoL scores and colour contrast (P < 0.01). The mean (CI 95%) reductions of the mMASI scores were 49% (36–61%) for PYC and 34% (16–47%) for PLAC. The reductions in mMASI scores and colorimetric contrast were superior for the PYC group (P < 0.05). The analysis of GAIS resulted in an improvement of 86% (CI 95%: 68–96%) for the participants in the PYC group and 55% (CI 95%: 32–73%) for those in the PLAC group. There were no adverse effects related to oral treatment. Conclusion: Pycnogenol is well-tolerated and increases the effectiveness of broad-spectrum sunscreen and the triple combination in the treatment of facial melasma in women. |
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French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trialBackground: Melasma can be recalcitrant to treatment, and relapses are common. Pycnogenol has been reported to be effective in treating melasma. Objective: To compare the efficacy, safety and tolerability of 75 mg pycnogenol taken orally twice a day vs. a placebo, in association with the triple combination and broad-spectrum sunscreen for the treatment of facial melasma. Methods: A randomized, double-blind, parallel, placebo-controlled study was conducted on 44 women with facial melasma in a single centre from May 2019 through November 2019. Patients with melasma were randomly assigned to orally take 75 mg pycnogenol (PYC) or a placebo (PLAC) twice a day for 60 days. Both groups also received tinted sunscreen [Sun Protection Factor (SPF) 50; Persistent Pigment Darkening (PPD) 17] for daytime use and a topical triple combination at bedtime. The primary outcome was a change from the baseline Modified Melasma Area Severity Index (mMASI) score. Secondary outcomes were improvements in the patients' quality of life (MELASQoL), colorimetric indices and Global Aesthetic Improvement Scale (GAIS). Results: All participants completed the trial. The mean (SD) age of the participants was 39 (7) years, and 91% were phototypes III–IV. Both groups exhibited a reduction in mMASI scores, MELASQoL scores and colour contrast (P < 0.01). The mean (CI 95%) reductions of the mMASI scores were 49% (36–61%) for PYC and 34% (16–47%) for PLAC. The reductions in mMASI scores and colorimetric contrast were superior for the PYC group (P < 0.05). The analysis of GAIS resulted in an improvement of 86% (CI 95%: 68–96%) for the participants in the PYC group and 55% (CI 95%: 32–73%) for those in the PLAC group. There were no adverse effects related to oral treatment. Conclusion: Pycnogenol is well-tolerated and increases the effectiveness of broad-spectrum sunscreen and the triple combination in the treatment of facial melasma in women.Departamento de Dermatologia e Radioterapia FMB-UnespDepartamento de Dermatologia e Radioterapia FMB-UnespUniversidade Estadual Paulista (Unesp)Lima, P. B. [UNESP]Dias, J. A.F. [UNESP]Esposito, A. C.C. [UNESP]Miot, L. D.B. [UNESP]Miot, H. A. [UNESP]2021-06-25T10:34:21Z2021-06-25T10:34:21Z2021-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article502-508http://dx.doi.org/10.1111/jdv.16896Journal of the European Academy of Dermatology and Venereology, v. 35, n. 2, p. 502-508, 2021.1468-30830926-9959http://hdl.handle.net/11449/20656510.1111/jdv.168962-s2.0-85091609983Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the European Academy of Dermatology and Venereologyinfo:eu-repo/semantics/openAccess2021-10-23T07:33:54Zoai:repositorio.unesp.br:11449/206565Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T07:33:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial |
title |
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial |
spellingShingle |
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial Lima, P. B. [UNESP] |
title_short |
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial |
title_full |
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial |
title_fullStr |
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial |
title_full_unstemmed |
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial |
title_sort |
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial |
author |
Lima, P. B. [UNESP] |
author_facet |
Lima, P. B. [UNESP] Dias, J. A.F. [UNESP] Esposito, A. C.C. [UNESP] Miot, L. D.B. [UNESP] Miot, H. A. [UNESP] |
author_role |
author |
author2 |
Dias, J. A.F. [UNESP] Esposito, A. C.C. [UNESP] Miot, L. D.B. [UNESP] Miot, H. A. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Lima, P. B. [UNESP] Dias, J. A.F. [UNESP] Esposito, A. C.C. [UNESP] Miot, L. D.B. [UNESP] Miot, H. A. [UNESP] |
description |
Background: Melasma can be recalcitrant to treatment, and relapses are common. Pycnogenol has been reported to be effective in treating melasma. Objective: To compare the efficacy, safety and tolerability of 75 mg pycnogenol taken orally twice a day vs. a placebo, in association with the triple combination and broad-spectrum sunscreen for the treatment of facial melasma. Methods: A randomized, double-blind, parallel, placebo-controlled study was conducted on 44 women with facial melasma in a single centre from May 2019 through November 2019. Patients with melasma were randomly assigned to orally take 75 mg pycnogenol (PYC) or a placebo (PLAC) twice a day for 60 days. Both groups also received tinted sunscreen [Sun Protection Factor (SPF) 50; Persistent Pigment Darkening (PPD) 17] for daytime use and a topical triple combination at bedtime. The primary outcome was a change from the baseline Modified Melasma Area Severity Index (mMASI) score. Secondary outcomes were improvements in the patients' quality of life (MELASQoL), colorimetric indices and Global Aesthetic Improvement Scale (GAIS). Results: All participants completed the trial. The mean (SD) age of the participants was 39 (7) years, and 91% were phototypes III–IV. Both groups exhibited a reduction in mMASI scores, MELASQoL scores and colour contrast (P < 0.01). The mean (CI 95%) reductions of the mMASI scores were 49% (36–61%) for PYC and 34% (16–47%) for PLAC. The reductions in mMASI scores and colorimetric contrast were superior for the PYC group (P < 0.05). The analysis of GAIS resulted in an improvement of 86% (CI 95%: 68–96%) for the participants in the PYC group and 55% (CI 95%: 32–73%) for those in the PLAC group. There were no adverse effects related to oral treatment. Conclusion: Pycnogenol is well-tolerated and increases the effectiveness of broad-spectrum sunscreen and the triple combination in the treatment of facial melasma in women. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:34:21Z 2021-06-25T10:34:21Z 2021-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jdv.16896 Journal of the European Academy of Dermatology and Venereology, v. 35, n. 2, p. 502-508, 2021. 1468-3083 0926-9959 http://hdl.handle.net/11449/206565 10.1111/jdv.16896 2-s2.0-85091609983 |
url |
http://dx.doi.org/10.1111/jdv.16896 http://hdl.handle.net/11449/206565 |
identifier_str_mv |
Journal of the European Academy of Dermatology and Venereology, v. 35, n. 2, p. 502-508, 2021. 1468-3083 0926-9959 10.1111/jdv.16896 2-s2.0-85091609983 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the European Academy of Dermatology and Venereology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
502-508 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803650087895695360 |