Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13533 |
Resumo: | Texto completo: acesso restrito. p.1101-1106 |
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Santos, Cleiton S.Macedo, Júlio O.Bandeira, Maurício de SousaChagas Júnior, Adenizar Delgado dasMcBride, Alan John AlexanderMcBride, Flavia Weykamp da CruzReis, Mitermayer Galvão dosAthanazio, Daniel AbensurSantos, Cleiton S.Macedo, Júlio O.Bandeira, Maurício de SousaChagas Júnior, Adenizar Delgado dasMcBride, Alan John AlexanderMcBride, Flavia Weykamp da CruzReis, Mitermayer Galvão dosAthanazio, Daniel Abensur2013-11-03T14:39:25Z20100022-2615http://repositorio.ufba.br/ri/handle/ri/13533v. 59, n. 9Texto completo: acesso restrito. p.1101-1106The mouse disease model has the advantage of a broad array of immunological and genetic tools available for basic research. Some studies on transgenic and/or mutant mouse strains as models for experimental leptospirosis have been reported; however, the wider use of such models is hampered by a poor understanding of the outcome of experimental leptospiral infection among the different mouse strains available. Here, the outcome of infection by a virulent strain of Leptospira interrogans serogroup Icterohaemorrhagiae strain Cop was studied in four commonly used wild-type mouse strains: A, CBA, BALB/c and C57BL/6. The end points evaluated in this study were survival, presence of kidney lesions, leptospiral load in kidney samples, microscopic agglutination test titre and anti-leptospiral IgG antibody levels. As expected, none of the mouse strains were susceptible to lethal leptospirosis. However, these strains developed specific pathologies associated with sublethal leptospirosis. The A and C57BL/6 strains exhibited a high leptospiral load in kidney samples and the CBA and C57BL/6 strains developed severe inflammatory lesions, whilst the BALB/c strain proved to be the most resistant to subclinical leptospirosis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-05T13:07:19Z No. of bitstreams: 1 Cleiton S. Santos.pdf: 493720 bytes, checksum: 7386cf0ca478243ae07a73bbf8b24c75 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-03T14:39:25Z (GMT) No. of bitstreams: 1 Cleiton S. Santos.pdf: 493720 bytes, checksum: 7386cf0ca478243ae07a73bbf8b24c75 (MD5)Made available in DSpace on 2013-11-03T14:39:25Z (GMT). No. of bitstreams: 1 Cleiton S. Santos.pdf: 493720 bytes, checksum: 7386cf0ca478243ae07a73bbf8b24c75 (MD5) Previous issue date: 2010http://dx.doi.org/10.1099/jmm.0.021089-0reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBADifferent outcomes of experimental leptospiral infection in mouse strains with distinct genotypesJournal of Medical Microbiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALCleiton S. Santos.pdfCleiton S. 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| dc.title.pt_BR.fl_str_mv |
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Medical Microbiology |
| title |
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes |
| spellingShingle |
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes Santos, Cleiton S. |
| title_short |
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes |
| title_full |
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes |
| title_fullStr |
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes |
| title_full_unstemmed |
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes |
| title_sort |
Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes |
| author |
Santos, Cleiton S. |
| author_facet |
Santos, Cleiton S. Macedo, Júlio O. Bandeira, Maurício de Sousa Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flavia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur |
| author_role |
author |
| author2 |
Macedo, Júlio O. Bandeira, Maurício de Sousa Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flavia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Cleiton S. Macedo, Júlio O. Bandeira, Maurício de Sousa Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flavia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur Santos, Cleiton S. Macedo, Júlio O. Bandeira, Maurício de Sousa Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flavia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur |
| description |
Texto completo: acesso restrito. p.1101-1106 |
| publishDate |
2010 |
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2010 |
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2013-11-03T14:39:25Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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0022-2615 |
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v. 59, n. 9 |
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0022-2615 v. 59, n. 9 |
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http://repositorio.ufba.br/ri/handle/ri/13533 |
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eng |
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