Molecular Targets of Drugs in the Treatment of COVID-19

Detalhes bibliográficos
Autor(a) principal: Silva Neto, Irineu Ferreira da
Data de Publicação: 2020
Outros Autores: Ricardino, Isadora Ellen Feitoza, Souza, Maria Nathalya Costa, Mendes, Rafael de Carvalho
Tipo de documento: Artigo
Idioma: por
Título da fonte: Cadernos de Prospecção (Online)
Texto Completo: https://periodicos.ufba.br/index.php/nit/article/view/38061
Resumo: Having a COVID-19 pandemic, several researchers are looking for pharmacological strategies for the treatment of this disease. Objective: to expose the pharmacological results most found in the literature, frequently used in the treatment of COVID-19. A literature review was carried out, based on the electronic databases SciELO and PubMed, using the following descriptors: Fármacos “Drugs”, Tratamento “Treatment” e COVID-19. Selected publications between December 2019 and June 2020. Among the products most used in the treatment of COVID-19 are: Redemsivir, Favipiravir, Ribavirin, Arbidol, Hydroxychloroquine, Azithromycin, Interferon combined with beta-1b and association between Lopinavir / Ritonavir. The effects of these drugs are inhibited by: dependent RNA polymerase, virus fusion with target cell membrane, endosomal acidification, viral exocytosis and papain and 3C protease. The importance of controlled studies and changes according to each country is emphasized, since the physiological profile of each population differs from another.
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spelling Molecular Targets of Drugs in the Treatment of COVID-19Alvos Moleculares dos Fármacos no Tratamento da COVID-19COVID-19Mecanismo de açãoTratamento.COVID-19Mechanism of Action Treatment.Having a COVID-19 pandemic, several researchers are looking for pharmacological strategies for the treatment of this disease. Objective: to expose the pharmacological results most found in the literature, frequently used in the treatment of COVID-19. A literature review was carried out, based on the electronic databases SciELO and PubMed, using the following descriptors: Fármacos “Drugs”, Tratamento “Treatment” e COVID-19. Selected publications between December 2019 and June 2020. Among the products most used in the treatment of COVID-19 are: Redemsivir, Favipiravir, Ribavirin, Arbidol, Hydroxychloroquine, Azithromycin, Interferon combined with beta-1b and association between Lopinavir / Ritonavir. The effects of these drugs are inhibited by: dependent RNA polymerase, virus fusion with target cell membrane, endosomal acidification, viral exocytosis and papain and 3C protease. The importance of controlled studies and changes according to each country is emphasized, since the physiological profile of each population differs from another.Devido à pandemia da COVID-19, vários pesquisadores estão buscando estratégias farmacológicas para o tratamento dessa enfermidade. Neste artigo pretende-se expor os alvos farmacológicos mais relevantes encontrados na literatura e que estão frequentemente sendo utilizados no tratamento da COVID-19. Foi realizada uma revisão de literatura por meio de busca nas bases de dados eletrônicas: SciELO e PubMed, para tanto, utilizou-se os seguintes descritores: Fármacos “Drugs”, Tratamento “Treatment” e COVID-19. Selecionou-se publicações entre dezembro de 2019 a junho de 2020. Entre os fármacos mais utilizados no tratamento da COVID-19, estão: Redemsivir, Favipiravir, Ribavirina, Arbidol, Hidroxicloroquina, Azitromicina, Interferon, combinado com beta-1b, e associação entre Lopinavir/Ritonavir. Os alvos dessas drogas incluem a inibição da RNA polimerase dependente, a fusão do vírus com a membrana da célula alvo, a acidificação endossômica e a exocitose viral e da protease do tipo papaína e 3C. Ressalta-se a importância de estudos controlados e específicos de acordo com cada país, visto que o perfil fisiológico da população se mostra diferente para cada uma.Universidade Federal da Bahia2020-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://periodicos.ufba.br/index.php/nit/article/view/3806110.9771/cp.v13i5.38061Cadernos de Prospecção; Vol. 13 No. 5 (2020); 1251Cadernos de Prospecção; v. 13 n. 5 (2020); 12512317-00261983-1358reponame:Cadernos de Prospecção (Online)instname:Universidade Federal da Bahia (UFBA)instacron:UFBAporhttps://periodicos.ufba.br/index.php/nit/article/view/38061/23028Copyright (c) 2020 Cadernos de Prospecçãohttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessSilva Neto, Irineu Ferreira daRicardino, Isadora Ellen FeitozaSouza, Maria Nathalya CostaMendes, Rafael de Carvalho2020-12-09T18:35:56Zoai:ojs.periodicos.ufba.br:article/38061Revistahttps://periodicos.ufba.br/index.php/nitPUBhttps://periodicos.ufba.br/index.php/nit/oaicadernosdeprospeccao@gmail.com || maliceribeiro@yahoo.com.br || cadernosdeprospeccao@gmail.com || saionaraluna@gmail.com2317-00261983-1358opendoar:2020-12-09T18:35:56Cadernos de Prospecção (Online) - Universidade Federal da Bahia (UFBA)false
dc.title.none.fl_str_mv Molecular Targets of Drugs in the Treatment of COVID-19
Alvos Moleculares dos Fármacos no Tratamento da COVID-19
title Molecular Targets of Drugs in the Treatment of COVID-19
spellingShingle Molecular Targets of Drugs in the Treatment of COVID-19
Silva Neto, Irineu Ferreira da
COVID-19
Mecanismo de ação
Tratamento.
COVID-19
Mechanism of Action
Treatment.
title_short Molecular Targets of Drugs in the Treatment of COVID-19
title_full Molecular Targets of Drugs in the Treatment of COVID-19
title_fullStr Molecular Targets of Drugs in the Treatment of COVID-19
title_full_unstemmed Molecular Targets of Drugs in the Treatment of COVID-19
title_sort Molecular Targets of Drugs in the Treatment of COVID-19
author Silva Neto, Irineu Ferreira da
author_facet Silva Neto, Irineu Ferreira da
Ricardino, Isadora Ellen Feitoza
Souza, Maria Nathalya Costa
Mendes, Rafael de Carvalho
author_role author
author2 Ricardino, Isadora Ellen Feitoza
Souza, Maria Nathalya Costa
Mendes, Rafael de Carvalho
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva Neto, Irineu Ferreira da
Ricardino, Isadora Ellen Feitoza
Souza, Maria Nathalya Costa
Mendes, Rafael de Carvalho
dc.subject.por.fl_str_mv COVID-19
Mecanismo de ação
Tratamento.
COVID-19
Mechanism of Action
Treatment.
topic COVID-19
Mecanismo de ação
Tratamento.
COVID-19
Mechanism of Action
Treatment.
description Having a COVID-19 pandemic, several researchers are looking for pharmacological strategies for the treatment of this disease. Objective: to expose the pharmacological results most found in the literature, frequently used in the treatment of COVID-19. A literature review was carried out, based on the electronic databases SciELO and PubMed, using the following descriptors: Fármacos “Drugs”, Tratamento “Treatment” e COVID-19. Selected publications between December 2019 and June 2020. Among the products most used in the treatment of COVID-19 are: Redemsivir, Favipiravir, Ribavirin, Arbidol, Hydroxychloroquine, Azithromycin, Interferon combined with beta-1b and association between Lopinavir / Ritonavir. The effects of these drugs are inhibited by: dependent RNA polymerase, virus fusion with target cell membrane, endosomal acidification, viral exocytosis and papain and 3C protease. The importance of controlled studies and changes according to each country is emphasized, since the physiological profile of each population differs from another.
publishDate 2020
dc.date.none.fl_str_mv 2020-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufba.br/index.php/nit/article/view/38061
10.9771/cp.v13i5.38061
url https://periodicos.ufba.br/index.php/nit/article/view/38061
identifier_str_mv 10.9771/cp.v13i5.38061
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.ufba.br/index.php/nit/article/view/38061/23028
dc.rights.driver.fl_str_mv Copyright (c) 2020 Cadernos de Prospecção
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Cadernos de Prospecção
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal da Bahia
publisher.none.fl_str_mv Universidade Federal da Bahia
dc.source.none.fl_str_mv Cadernos de Prospecção; Vol. 13 No. 5 (2020); 1251
Cadernos de Prospecção; v. 13 n. 5 (2020); 1251
2317-0026
1983-1358
reponame:Cadernos de Prospecção (Online)
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Cadernos de Prospecção (Online)
collection Cadernos de Prospecção (Online)
repository.name.fl_str_mv Cadernos de Prospecção (Online) - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv cadernosdeprospeccao@gmail.com || maliceribeiro@yahoo.com.br || cadernosdeprospeccao@gmail.com || saionaraluna@gmail.com
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