THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES

Detalhes bibliográficos
Autor(a) principal: Fávaro, Wagner
Data de Publicação: 2020
Outros Autores: Durán, Nelson
Tipo de documento: preprint
Idioma: eng
Título da fonte: SciELO Preprints
Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/866
Resumo: Many well-known commercial pharmaceuticals have been used in the therapy against SARS-CoV-2, although in a random and experimental way, since this use is only based on the knowledge about culture cells in vitro. But, it is widely known that it is not correlated with assays in vivo conducted with in animals or with clinical trials in humans. Knowledge about treatments applied to previous pandemic infections caused by viruses such as MERS and SARS may be the most interesting strategy used to screen products with potential to act against SARS-CoV-2. Mechanistic aspects of virus infections and antiviral action mechanisms were herein analyzed based on the assumption that these commercial pharmaceuticals can eliminate the virus. Perspectives about these procedures, as well as about finished clinical trials and the ones yet in progress, were also addressed in the current study.
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spelling THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVESLOS FARMACÉUTICOS ANTIVIRALES MÁS PROMINENTES UTILIZADOS CONTRA COVID-19 Y SUS PERSPECTIVASOS MEDICAMENTOS ANTIVIRAIS MAIS PROMINENTES USADOS CONTRA COVID-19 E SUAS PERSPECTIVASCOVID-19TratamentoMecanismo de AçãoSARS-CoV-2COVID-19TreatmentMechanism of actionSARS-CoV-2COVID-19Tratamientomecanismo de acciónSARS-CoV-2Many well-known commercial pharmaceuticals have been used in the therapy against SARS-CoV-2, although in a random and experimental way, since this use is only based on the knowledge about culture cells in vitro. But, it is widely known that it is not correlated with assays in vivo conducted with in animals or with clinical trials in humans. Knowledge about treatments applied to previous pandemic infections caused by viruses such as MERS and SARS may be the most interesting strategy used to screen products with potential to act against SARS-CoV-2. Mechanistic aspects of virus infections and antiviral action mechanisms were herein analyzed based on the assumption that these commercial pharmaceuticals can eliminate the virus. Perspectives about these procedures, as well as about finished clinical trials and the ones yet in progress, were also addressed in the current study.Muchos productos farmacéuticos comerciales bien conocidos se han utilizado en la terapia contra el SARS-CoV-2, aunque de manera aleatoria y experimental, ya que este uso solo se basa en el conocimiento sobre células de cultivo in vitro. Pero, es ampliamente conocido que no está correlacionado con ensayos in vivo realizados con animales o con ensayos clínicos en humanos. El conocimiento sobre los tratamientos aplicados a infecciones pandémicas previas causadas por virus como MERS y SARS puede ser la estrategia más interesante utilizada para detectar productos con potencial para actuar contra el SARS-CoV-2. Los aspectos mecanicistas de las infecciones por virus y los mecanismos de acción antivirales se analizaron en este documento basándose en el supuesto de que estos productos farmacéuticos comerciales pueden eliminar el virus. Las perspectivas sobre estos procedimientos, así como sobre los ensayos clínicos terminados y los que aún están en progreso, también se abordaron en el estudio actual.Muitos fármacos comerciais bem conhecidos têm sido utilizados na terapia contra SARS-CoV-2, embora de maneira aleatória e experimental, uma vez que esse uso é baseado apenas no conhecimento sobre cultura de células in vitro. Entretanto, sabe-se o que não está correlacionado com ensaios in vivo realizados com animais ou com ensaios clínicos em humanos. O conhecimento sobre tratamentos aplicados a infecções pandêmicas anteriores causadas por vírus como MERS e SARS pode ser a estratégia mais interessante usada para rastrear produtos com potencial para agir contra o SARS-CoV-2. Aspectos mecanísticos de infecções por vírus e mecanismos de ação antiviral foram aqui analisados com base no pressuposto de que esses produtos farmacêuticos comerciais podem eliminar o vírus. As perspectivas sobre esses procedimentos, bem como sobre os ensaios clínicos concluídos e os que ainda estão em andamento, também foram abordados no presente estudo.SciELO PreprintsSciELO PreprintsSciELO Preprints2020-06-30info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/86610.1590/SciELOPreprints.866enghttps://preprints.scielo.org/index.php/scielo/article/view/866/1201Copyright (c) 2020 Wagner Fávaro, Nelson Duránhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFávaro, WagnerDurán, Nelsonreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2020-06-28T23:43:55Zoai:ops.preprints.scielo.org:preprint/866Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2020-06-28T23:43:55SciELO Preprints - SciELOfalse
dc.title.none.fl_str_mv THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
LOS FARMACÉUTICOS ANTIVIRALES MÁS PROMINENTES UTILIZADOS CONTRA COVID-19 Y SUS PERSPECTIVAS
OS MEDICAMENTOS ANTIVIRAIS MAIS PROMINENTES USADOS CONTRA COVID-19 E SUAS PERSPECTIVAS
title THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
spellingShingle THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
Fávaro, Wagner
COVID-19
Tratamento
Mecanismo de Ação
SARS-CoV-2
COVID-19
Treatment
Mechanism of action
SARS-CoV-2
COVID-19
Tratamiento
mecanismo de acción
SARS-CoV-2
title_short THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
title_full THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
title_fullStr THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
title_full_unstemmed THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
title_sort THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
author Fávaro, Wagner
author_facet Fávaro, Wagner
Durán, Nelson
author_role author
author2 Durán, Nelson
author2_role author
dc.contributor.author.fl_str_mv Fávaro, Wagner
Durán, Nelson
dc.subject.por.fl_str_mv COVID-19
Tratamento
Mecanismo de Ação
SARS-CoV-2
COVID-19
Treatment
Mechanism of action
SARS-CoV-2
COVID-19
Tratamiento
mecanismo de acción
SARS-CoV-2
topic COVID-19
Tratamento
Mecanismo de Ação
SARS-CoV-2
COVID-19
Treatment
Mechanism of action
SARS-CoV-2
COVID-19
Tratamiento
mecanismo de acción
SARS-CoV-2
description Many well-known commercial pharmaceuticals have been used in the therapy against SARS-CoV-2, although in a random and experimental way, since this use is only based on the knowledge about culture cells in vitro. But, it is widely known that it is not correlated with assays in vivo conducted with in animals or with clinical trials in humans. Knowledge about treatments applied to previous pandemic infections caused by viruses such as MERS and SARS may be the most interesting strategy used to screen products with potential to act against SARS-CoV-2. Mechanistic aspects of virus infections and antiviral action mechanisms were herein analyzed based on the assumption that these commercial pharmaceuticals can eliminate the virus. Perspectives about these procedures, as well as about finished clinical trials and the ones yet in progress, were also addressed in the current study.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/preprint
info:eu-repo/semantics/publishedVersion
format preprint
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://preprints.scielo.org/index.php/scielo/preprint/view/866
10.1590/SciELOPreprints.866
url https://preprints.scielo.org/index.php/scielo/preprint/view/866
identifier_str_mv 10.1590/SciELOPreprints.866
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://preprints.scielo.org/index.php/scielo/article/view/866/1201
dc.rights.driver.fl_str_mv Copyright (c) 2020 Wagner Fávaro, Nelson Durán
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Wagner Fávaro, Nelson Durán
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
dc.source.none.fl_str_mv reponame:SciELO Preprints
instname:SciELO
instacron:SCI
instname_str SciELO
instacron_str SCI
institution SCI
reponame_str SciELO Preprints
collection SciELO Preprints
repository.name.fl_str_mv SciELO Preprints - SciELO
repository.mail.fl_str_mv scielo.submission@scielo.org
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