Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage

Detalhes bibliográficos
Autor(a) principal: Andrade Neto, João Batista de
Data de Publicação: 2015
Outros Autores: Silva, Cecília Rocha da, Campos, Rosana de Sousa, Nascimento, Francisca Bruna Stefany Aires do, Freitas, Daniel Domingues, Josino, Maria Aparecida Alexandre, Andrade, Larissa Nara Dantas de, Gonçalves, Thially Braga, Mesquita, Jacó Ricarte Lima de, Magalhães, Hemerson Iury Ferreira, Rodrigues, Felipe Augusto Rocha, Gaspar, Danielle Macedo, Moraes Filho, Manoel Odorico de, Lobo, Marina Duarte Pinto, Moreno, Frederico Bruno Mendes Batista, Grangeiro, Thalles Barbosa, Gomes, Akenaton Onassis Cardoso Viana, Nascente, Luciana de Camargo, Romeiro, Luiz Antonio Soares, Cavalcanti, Bruno Coelho, Nobre Júnior, Hélio Vitoriano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/18743
Resumo: Recently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural products by modulating relevant biological properties. The present study evaluated the antifungal effect of piperonal nitro derivatives (PNDs) in Candida spp. strains resistant to fluconazole. The assessment of the antifungal effect was determined both by broth dilution and flow cytometry, as well as by the assessment of a potential mechanism of action of these compounds. All of the tested strains were susceptible to the tested compounds. Treatment with PNDs (1, 2 and 3) led to programmed cell death in Candida spp., probably because they play an antifungal role in specific DNA surrounding sites. In addition, ROS production was found to play a role in this process, observed as oxidative damage to DNA purine and pyrimidine bases. The PND compounds (1, 2 and 3) presented antifungal activity in vitro against strains of fluconazoleresistant Candida spp.
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spelling Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damageCandidaFluconazolRecently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural products by modulating relevant biological properties. The present study evaluated the antifungal effect of piperonal nitro derivatives (PNDs) in Candida spp. strains resistant to fluconazole. The assessment of the antifungal effect was determined both by broth dilution and flow cytometry, as well as by the assessment of a potential mechanism of action of these compounds. All of the tested strains were susceptible to the tested compounds. Treatment with PNDs (1, 2 and 3) led to programmed cell death in Candida spp., probably because they play an antifungal role in specific DNA surrounding sites. In addition, ROS production was found to play a role in this process, observed as oxidative damage to DNA purine and pyrimidine bases. The PND compounds (1, 2 and 3) presented antifungal activity in vitro against strains of fluconazoleresistant Candida spp.International Journal of Current Microbiology and Applied Sciences2016-07-28T16:34:12Z2016-07-28T16:34:12Z2015-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANDRADE NETO, J. B. et al. Effects of piperonal nitro derivatives on candida species : antifungal activity against Fluconazole - resistant strains is associated with oxidative DNA damage. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 4, p. 777-792, abr. 2015.2319 - 7706http://www.repositorio.ufc.br/handle/riufc/18743Andrade Neto, João Batista deSilva, Cecília Rocha daCampos, Rosana de SousaNascimento, Francisca Bruna Stefany Aires doFreitas, Daniel DominguesJosino, Maria Aparecida AlexandreAndrade, Larissa Nara Dantas deGonçalves, Thially BragaMesquita, Jacó Ricarte Lima deMagalhães, Hemerson Iury FerreiraRodrigues, Felipe Augusto RochaGaspar, Danielle MacedoMoraes Filho, Manoel Odorico deLobo, Marina Duarte PintoMoreno, Frederico Bruno Mendes BatistaGrangeiro, Thalles BarbosaGomes, Akenaton Onassis Cardoso VianaNascente, Luciana de CamargoRomeiro, Luiz Antonio SoaresCavalcanti, Bruno CoelhoNobre Júnior, Hélio Vitorianoengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-04-18T19:30:35Zoai:repositorio.ufc.br:riufc/18743Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:20:23.379548Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
title Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
spellingShingle Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
Andrade Neto, João Batista de
Candida
Fluconazol
title_short Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
title_full Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
title_fullStr Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
title_full_unstemmed Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
title_sort Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
author Andrade Neto, João Batista de
author_facet Andrade Neto, João Batista de
Silva, Cecília Rocha da
Campos, Rosana de Sousa
Nascimento, Francisca Bruna Stefany Aires do
Freitas, Daniel Domingues
Josino, Maria Aparecida Alexandre
Andrade, Larissa Nara Dantas de
Gonçalves, Thially Braga
Mesquita, Jacó Ricarte Lima de
Magalhães, Hemerson Iury Ferreira
Rodrigues, Felipe Augusto Rocha
Gaspar, Danielle Macedo
Moraes Filho, Manoel Odorico de
Lobo, Marina Duarte Pinto
Moreno, Frederico Bruno Mendes Batista
Grangeiro, Thalles Barbosa
Gomes, Akenaton Onassis Cardoso Viana
Nascente, Luciana de Camargo
Romeiro, Luiz Antonio Soares
Cavalcanti, Bruno Coelho
Nobre Júnior, Hélio Vitoriano
author_role author
author2 Silva, Cecília Rocha da
Campos, Rosana de Sousa
Nascimento, Francisca Bruna Stefany Aires do
Freitas, Daniel Domingues
Josino, Maria Aparecida Alexandre
Andrade, Larissa Nara Dantas de
Gonçalves, Thially Braga
Mesquita, Jacó Ricarte Lima de
Magalhães, Hemerson Iury Ferreira
Rodrigues, Felipe Augusto Rocha
Gaspar, Danielle Macedo
Moraes Filho, Manoel Odorico de
Lobo, Marina Duarte Pinto
Moreno, Frederico Bruno Mendes Batista
Grangeiro, Thalles Barbosa
Gomes, Akenaton Onassis Cardoso Viana
Nascente, Luciana de Camargo
Romeiro, Luiz Antonio Soares
Cavalcanti, Bruno Coelho
Nobre Júnior, Hélio Vitoriano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade Neto, João Batista de
Silva, Cecília Rocha da
Campos, Rosana de Sousa
Nascimento, Francisca Bruna Stefany Aires do
Freitas, Daniel Domingues
Josino, Maria Aparecida Alexandre
Andrade, Larissa Nara Dantas de
Gonçalves, Thially Braga
Mesquita, Jacó Ricarte Lima de
Magalhães, Hemerson Iury Ferreira
Rodrigues, Felipe Augusto Rocha
Gaspar, Danielle Macedo
Moraes Filho, Manoel Odorico de
Lobo, Marina Duarte Pinto
Moreno, Frederico Bruno Mendes Batista
Grangeiro, Thalles Barbosa
Gomes, Akenaton Onassis Cardoso Viana
Nascente, Luciana de Camargo
Romeiro, Luiz Antonio Soares
Cavalcanti, Bruno Coelho
Nobre Júnior, Hélio Vitoriano
dc.subject.por.fl_str_mv Candida
Fluconazol
topic Candida
Fluconazol
description Recently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural products by modulating relevant biological properties. The present study evaluated the antifungal effect of piperonal nitro derivatives (PNDs) in Candida spp. strains resistant to fluconazole. The assessment of the antifungal effect was determined both by broth dilution and flow cytometry, as well as by the assessment of a potential mechanism of action of these compounds. All of the tested strains were susceptible to the tested compounds. Treatment with PNDs (1, 2 and 3) led to programmed cell death in Candida spp., probably because they play an antifungal role in specific DNA surrounding sites. In addition, ROS production was found to play a role in this process, observed as oxidative damage to DNA purine and pyrimidine bases. The PND compounds (1, 2 and 3) presented antifungal activity in vitro against strains of fluconazoleresistant Candida spp.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
2016-07-28T16:34:12Z
2016-07-28T16:34:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv ANDRADE NETO, J. B. et al. Effects of piperonal nitro derivatives on candida species : antifungal activity against Fluconazole - resistant strains is associated with oxidative DNA damage. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 4, p. 777-792, abr. 2015.
2319 - 7706
http://www.repositorio.ufc.br/handle/riufc/18743
identifier_str_mv ANDRADE NETO, J. B. et al. Effects of piperonal nitro derivatives on candida species : antifungal activity against Fluconazole - resistant strains is associated with oxidative DNA damage. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 4, p. 777-792, abr. 2015.
2319 - 7706
url http://www.repositorio.ufc.br/handle/riufc/18743
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Journal of Current Microbiology and Applied Sciences
publisher.none.fl_str_mv International Journal of Current Microbiology and Applied Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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