Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/18743 |
Resumo: | Recently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural products by modulating relevant biological properties. The present study evaluated the antifungal effect of piperonal nitro derivatives (PNDs) in Candida spp. strains resistant to fluconazole. The assessment of the antifungal effect was determined both by broth dilution and flow cytometry, as well as by the assessment of a potential mechanism of action of these compounds. All of the tested strains were susceptible to the tested compounds. Treatment with PNDs (1, 2 and 3) led to programmed cell death in Candida spp., probably because they play an antifungal role in specific DNA surrounding sites. In addition, ROS production was found to play a role in this process, observed as oxidative damage to DNA purine and pyrimidine bases. The PND compounds (1, 2 and 3) presented antifungal activity in vitro against strains of fluconazoleresistant Candida spp. |
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Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damageCandidaFluconazolRecently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural products by modulating relevant biological properties. The present study evaluated the antifungal effect of piperonal nitro derivatives (PNDs) in Candida spp. strains resistant to fluconazole. The assessment of the antifungal effect was determined both by broth dilution and flow cytometry, as well as by the assessment of a potential mechanism of action of these compounds. All of the tested strains were susceptible to the tested compounds. Treatment with PNDs (1, 2 and 3) led to programmed cell death in Candida spp., probably because they play an antifungal role in specific DNA surrounding sites. In addition, ROS production was found to play a role in this process, observed as oxidative damage to DNA purine and pyrimidine bases. The PND compounds (1, 2 and 3) presented antifungal activity in vitro against strains of fluconazoleresistant Candida spp.International Journal of Current Microbiology and Applied Sciences2016-07-28T16:34:12Z2016-07-28T16:34:12Z2015-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANDRADE NETO, J. B. et al. Effects of piperonal nitro derivatives on candida species : antifungal activity against Fluconazole - resistant strains is associated with oxidative DNA damage. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 4, p. 777-792, abr. 2015.2319 - 7706http://www.repositorio.ufc.br/handle/riufc/18743Andrade Neto, João Batista deSilva, Cecília Rocha daCampos, Rosana de SousaNascimento, Francisca Bruna Stefany Aires doFreitas, Daniel DominguesJosino, Maria Aparecida AlexandreAndrade, Larissa Nara Dantas deGonçalves, Thially BragaMesquita, Jacó Ricarte Lima deMagalhães, Hemerson Iury FerreiraRodrigues, Felipe Augusto RochaGaspar, Danielle MacedoMoraes Filho, Manoel Odorico deLobo, Marina Duarte PintoMoreno, Frederico Bruno Mendes BatistaGrangeiro, Thalles BarbosaGomes, Akenaton Onassis Cardoso VianaNascente, Luciana de CamargoRomeiro, Luiz Antonio SoaresCavalcanti, Bruno CoelhoNobre Júnior, Hélio Vitorianoengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-04-18T19:30:35Zoai:repositorio.ufc.br:riufc/18743Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:20:23.379548Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage |
title |
Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage |
spellingShingle |
Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage Andrade Neto, João Batista de Candida Fluconazol |
title_short |
Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage |
title_full |
Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage |
title_fullStr |
Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage |
title_full_unstemmed |
Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage |
title_sort |
Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage |
author |
Andrade Neto, João Batista de |
author_facet |
Andrade Neto, João Batista de Silva, Cecília Rocha da Campos, Rosana de Sousa Nascimento, Francisca Bruna Stefany Aires do Freitas, Daniel Domingues Josino, Maria Aparecida Alexandre Andrade, Larissa Nara Dantas de Gonçalves, Thially Braga Mesquita, Jacó Ricarte Lima de Magalhães, Hemerson Iury Ferreira Rodrigues, Felipe Augusto Rocha Gaspar, Danielle Macedo Moraes Filho, Manoel Odorico de Lobo, Marina Duarte Pinto Moreno, Frederico Bruno Mendes Batista Grangeiro, Thalles Barbosa Gomes, Akenaton Onassis Cardoso Viana Nascente, Luciana de Camargo Romeiro, Luiz Antonio Soares Cavalcanti, Bruno Coelho Nobre Júnior, Hélio Vitoriano |
author_role |
author |
author2 |
Silva, Cecília Rocha da Campos, Rosana de Sousa Nascimento, Francisca Bruna Stefany Aires do Freitas, Daniel Domingues Josino, Maria Aparecida Alexandre Andrade, Larissa Nara Dantas de Gonçalves, Thially Braga Mesquita, Jacó Ricarte Lima de Magalhães, Hemerson Iury Ferreira Rodrigues, Felipe Augusto Rocha Gaspar, Danielle Macedo Moraes Filho, Manoel Odorico de Lobo, Marina Duarte Pinto Moreno, Frederico Bruno Mendes Batista Grangeiro, Thalles Barbosa Gomes, Akenaton Onassis Cardoso Viana Nascente, Luciana de Camargo Romeiro, Luiz Antonio Soares Cavalcanti, Bruno Coelho Nobre Júnior, Hélio Vitoriano |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade Neto, João Batista de Silva, Cecília Rocha da Campos, Rosana de Sousa Nascimento, Francisca Bruna Stefany Aires do Freitas, Daniel Domingues Josino, Maria Aparecida Alexandre Andrade, Larissa Nara Dantas de Gonçalves, Thially Braga Mesquita, Jacó Ricarte Lima de Magalhães, Hemerson Iury Ferreira Rodrigues, Felipe Augusto Rocha Gaspar, Danielle Macedo Moraes Filho, Manoel Odorico de Lobo, Marina Duarte Pinto Moreno, Frederico Bruno Mendes Batista Grangeiro, Thalles Barbosa Gomes, Akenaton Onassis Cardoso Viana Nascente, Luciana de Camargo Romeiro, Luiz Antonio Soares Cavalcanti, Bruno Coelho Nobre Júnior, Hélio Vitoriano |
dc.subject.por.fl_str_mv |
Candida Fluconazol |
topic |
Candida Fluconazol |
description |
Recently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural products by modulating relevant biological properties. The present study evaluated the antifungal effect of piperonal nitro derivatives (PNDs) in Candida spp. strains resistant to fluconazole. The assessment of the antifungal effect was determined both by broth dilution and flow cytometry, as well as by the assessment of a potential mechanism of action of these compounds. All of the tested strains were susceptible to the tested compounds. Treatment with PNDs (1, 2 and 3) led to programmed cell death in Candida spp., probably because they play an antifungal role in specific DNA surrounding sites. In addition, ROS production was found to play a role in this process, observed as oxidative damage to DNA purine and pyrimidine bases. The PND compounds (1, 2 and 3) presented antifungal activity in vitro against strains of fluconazoleresistant Candida spp. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04 2016-07-28T16:34:12Z 2016-07-28T16:34:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ANDRADE NETO, J. B. et al. Effects of piperonal nitro derivatives on candida species : antifungal activity against Fluconazole - resistant strains is associated with oxidative DNA damage. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 4, p. 777-792, abr. 2015. 2319 - 7706 http://www.repositorio.ufc.br/handle/riufc/18743 |
identifier_str_mv |
ANDRADE NETO, J. B. et al. Effects of piperonal nitro derivatives on candida species : antifungal activity against Fluconazole - resistant strains is associated with oxidative DNA damage. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 4, p. 777-792, abr. 2015. 2319 - 7706 |
url |
http://www.repositorio.ufc.br/handle/riufc/18743 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
International Journal of Current Microbiology and Applied Sciences |
publisher.none.fl_str_mv |
International Journal of Current Microbiology and Applied Sciences |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028761921126400 |