Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis

Detalhes bibliográficos
Autor(a) principal: Andrade Neto, João Batista de
Data de Publicação: 2015
Outros Autores: Silva, Cecília Rocha da, Campos, Rosana de Sousa, Nascimento, Francisca Bruna Stefany Aires do, Sampaio, Letícia Serpa, Silva, Anderson R. da, Silva, Rose A.C., Freitas, Daniel D. de, Josino, Maria Aparecida, Andrade, Larissa Nara Dantas de, Magalhães, Hemerson Iury Ferreira, Gaspar, Danielle Macedo, Moraes Filho, Manoel Odorico de, Silveira, Edilberto R., Gomes, Akenaton Onassis Cardoso Viana, Câmara, Claudio A.G., Lima, Iri Sandro Pampolha, Cavalcanti, Bruno Coêlho, Nobre Júnior, Hélio Vitoriano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
dARK ID: ark:/83112/001300001kj0p
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/17649
Resumo: Candida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated with a highly mortality rate. Furthermore, antifungal drug resistance (i.e. resistance to azole compounds) is a prominent feature in the management of invasive mycoses, and its epidemiological characteristics continue to evolve. This scenario leads to seek for new candidates for antifungal drugs able to overcome the resistance issues of Candida species. Kaurenoic acid (KA) or ent-kaur-16-en-19-oic acid is a tetracyclic diterpene present in several plants known to exert several pharmacological activities such cytotoxic actions and antimicrobial in vitro. The aim of current study was evaluate the potential antifungal of the natural diterpenoids kauren-19-oic acid (KA), 14-hydroxy-kaurane (1) and xylopic acid (2), and semi-synthetic derivatives of KA (3-5) towards Candida parapsilosis. Six combinations formed by different diterpenoids kauren-19-oic acid (KA), compounds (1-5), were tested using varied fluconazole concentration. We concluded that the compound 4 (16 -methoxy-( )-kauran-19-oic methylester) when combined with fluconazole, show activity against strains of C. parapsilosis resistant to fluconazole.
id UFC-7_c923558695688bd6a1dcd9ece3a9fedc
oai_identifier_str oai:repositorio.ufc.br:riufc/17649
network_acronym_str UFC-7
network_name_str Repositório Institucional da Universidade Federal do Ceará (UFC)
repository_id_str
spelling Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosisFluconazolImunidade InataCandidaCandida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated with a highly mortality rate. Furthermore, antifungal drug resistance (i.e. resistance to azole compounds) is a prominent feature in the management of invasive mycoses, and its epidemiological characteristics continue to evolve. This scenario leads to seek for new candidates for antifungal drugs able to overcome the resistance issues of Candida species. Kaurenoic acid (KA) or ent-kaur-16-en-19-oic acid is a tetracyclic diterpene present in several plants known to exert several pharmacological activities such cytotoxic actions and antimicrobial in vitro. The aim of current study was evaluate the potential antifungal of the natural diterpenoids kauren-19-oic acid (KA), 14-hydroxy-kaurane (1) and xylopic acid (2), and semi-synthetic derivatives of KA (3-5) towards Candida parapsilosis. Six combinations formed by different diterpenoids kauren-19-oic acid (KA), compounds (1-5), were tested using varied fluconazole concentration. We concluded that the compound 4 (16 -methoxy-( )-kauran-19-oic methylester) when combined with fluconazole, show activity against strains of C. parapsilosis resistant to fluconazole.International Journal of Current Microbiology and Applied Sciences2016-06-14T15:44:37Z2016-06-14T15:44:37Z2015-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANDRADE NETO, J. B. de et al. Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole against strains of fluconazole-resistant Candida parapsilosis. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 5, p. 68-79, may. 2015.2319-7692 (Print)2319-7706 (Online)http://www.repositorio.ufc.br/handle/riufc/17649ark:/83112/001300001kj0pAndrade Neto, João Batista deSilva, Cecília Rocha daCampos, Rosana de SousaNascimento, Francisca Bruna Stefany Aires doSampaio, Letícia SerpaSilva, Anderson R. daSilva, Rose A.C.Freitas, Daniel D. deJosino, Maria AparecidaAndrade, Larissa Nara Dantas deMagalhães, Hemerson Iury FerreiraGaspar, Danielle MacedoMoraes Filho, Manoel Odorico deSilveira, Edilberto R.Gomes, Akenaton Onassis Cardoso VianaCâmara, Claudio A.G.Lima, Iri Sandro PampolhaCavalcanti, Bruno CoêlhoNobre Júnior, Hélio Vitorianoengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-04-18T19:31:08Zoai:repositorio.ufc.br:riufc/17649Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:48:13.703111Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
title Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
spellingShingle Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
Andrade Neto, João Batista de
Fluconazol
Imunidade Inata
Candida
title_short Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
title_full Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
title_fullStr Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
title_full_unstemmed Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
title_sort Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
author Andrade Neto, João Batista de
author_facet Andrade Neto, João Batista de
Silva, Cecília Rocha da
Campos, Rosana de Sousa
Nascimento, Francisca Bruna Stefany Aires do
Sampaio, Letícia Serpa
Silva, Anderson R. da
Silva, Rose A.C.
Freitas, Daniel D. de
Josino, Maria Aparecida
Andrade, Larissa Nara Dantas de
Magalhães, Hemerson Iury Ferreira
Gaspar, Danielle Macedo
Moraes Filho, Manoel Odorico de
Silveira, Edilberto R.
Gomes, Akenaton Onassis Cardoso Viana
Câmara, Claudio A.G.
Lima, Iri Sandro Pampolha
Cavalcanti, Bruno Coêlho
Nobre Júnior, Hélio Vitoriano
author_role author
author2 Silva, Cecília Rocha da
Campos, Rosana de Sousa
Nascimento, Francisca Bruna Stefany Aires do
Sampaio, Letícia Serpa
Silva, Anderson R. da
Silva, Rose A.C.
Freitas, Daniel D. de
Josino, Maria Aparecida
Andrade, Larissa Nara Dantas de
Magalhães, Hemerson Iury Ferreira
Gaspar, Danielle Macedo
Moraes Filho, Manoel Odorico de
Silveira, Edilberto R.
Gomes, Akenaton Onassis Cardoso Viana
Câmara, Claudio A.G.
Lima, Iri Sandro Pampolha
Cavalcanti, Bruno Coêlho
Nobre Júnior, Hélio Vitoriano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade Neto, João Batista de
Silva, Cecília Rocha da
Campos, Rosana de Sousa
Nascimento, Francisca Bruna Stefany Aires do
Sampaio, Letícia Serpa
Silva, Anderson R. da
Silva, Rose A.C.
Freitas, Daniel D. de
Josino, Maria Aparecida
Andrade, Larissa Nara Dantas de
Magalhães, Hemerson Iury Ferreira
Gaspar, Danielle Macedo
Moraes Filho, Manoel Odorico de
Silveira, Edilberto R.
Gomes, Akenaton Onassis Cardoso Viana
Câmara, Claudio A.G.
Lima, Iri Sandro Pampolha
Cavalcanti, Bruno Coêlho
Nobre Júnior, Hélio Vitoriano
dc.subject.por.fl_str_mv Fluconazol
Imunidade Inata
Candida
topic Fluconazol
Imunidade Inata
Candida
description Candida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated with a highly mortality rate. Furthermore, antifungal drug resistance (i.e. resistance to azole compounds) is a prominent feature in the management of invasive mycoses, and its epidemiological characteristics continue to evolve. This scenario leads to seek for new candidates for antifungal drugs able to overcome the resistance issues of Candida species. Kaurenoic acid (KA) or ent-kaur-16-en-19-oic acid is a tetracyclic diterpene present in several plants known to exert several pharmacological activities such cytotoxic actions and antimicrobial in vitro. The aim of current study was evaluate the potential antifungal of the natural diterpenoids kauren-19-oic acid (KA), 14-hydroxy-kaurane (1) and xylopic acid (2), and semi-synthetic derivatives of KA (3-5) towards Candida parapsilosis. Six combinations formed by different diterpenoids kauren-19-oic acid (KA), compounds (1-5), were tested using varied fluconazole concentration. We concluded that the compound 4 (16 -methoxy-( )-kauran-19-oic methylester) when combined with fluconazole, show activity against strains of C. parapsilosis resistant to fluconazole.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
2016-06-14T15:44:37Z
2016-06-14T15:44:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv ANDRADE NETO, J. B. de et al. Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole against strains of fluconazole-resistant Candida parapsilosis. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 5, p. 68-79, may. 2015.
2319-7692 (Print)
2319-7706 (Online)
http://www.repositorio.ufc.br/handle/riufc/17649
dc.identifier.dark.fl_str_mv ark:/83112/001300001kj0p
identifier_str_mv ANDRADE NETO, J. B. de et al. Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole against strains of fluconazole-resistant Candida parapsilosis. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 5, p. 68-79, may. 2015.
2319-7692 (Print)
2319-7706 (Online)
ark:/83112/001300001kj0p
url http://www.repositorio.ufc.br/handle/riufc/17649
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Journal of Current Microbiology and Applied Sciences
publisher.none.fl_str_mv International Journal of Current Microbiology and Applied Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1818373978549387264