Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
dARK ID: | ark:/83112/001300001kj0p |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/17649 |
Resumo: | Candida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated with a highly mortality rate. Furthermore, antifungal drug resistance (i.e. resistance to azole compounds) is a prominent feature in the management of invasive mycoses, and its epidemiological characteristics continue to evolve. This scenario leads to seek for new candidates for antifungal drugs able to overcome the resistance issues of Candida species. Kaurenoic acid (KA) or ent-kaur-16-en-19-oic acid is a tetracyclic diterpene present in several plants known to exert several pharmacological activities such cytotoxic actions and antimicrobial in vitro. The aim of current study was evaluate the potential antifungal of the natural diterpenoids kauren-19-oic acid (KA), 14-hydroxy-kaurane (1) and xylopic acid (2), and semi-synthetic derivatives of KA (3-5) towards Candida parapsilosis. Six combinations formed by different diterpenoids kauren-19-oic acid (KA), compounds (1-5), were tested using varied fluconazole concentration. We concluded that the compound 4 (16 -methoxy-( )-kauran-19-oic methylester) when combined with fluconazole, show activity against strains of C. parapsilosis resistant to fluconazole. |
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Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosisFluconazolImunidade InataCandidaCandida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated with a highly mortality rate. Furthermore, antifungal drug resistance (i.e. resistance to azole compounds) is a prominent feature in the management of invasive mycoses, and its epidemiological characteristics continue to evolve. This scenario leads to seek for new candidates for antifungal drugs able to overcome the resistance issues of Candida species. Kaurenoic acid (KA) or ent-kaur-16-en-19-oic acid is a tetracyclic diterpene present in several plants known to exert several pharmacological activities such cytotoxic actions and antimicrobial in vitro. The aim of current study was evaluate the potential antifungal of the natural diterpenoids kauren-19-oic acid (KA), 14-hydroxy-kaurane (1) and xylopic acid (2), and semi-synthetic derivatives of KA (3-5) towards Candida parapsilosis. Six combinations formed by different diterpenoids kauren-19-oic acid (KA), compounds (1-5), were tested using varied fluconazole concentration. We concluded that the compound 4 (16 -methoxy-( )-kauran-19-oic methylester) when combined with fluconazole, show activity against strains of C. parapsilosis resistant to fluconazole.International Journal of Current Microbiology and Applied Sciences2016-06-14T15:44:37Z2016-06-14T15:44:37Z2015-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANDRADE NETO, J. B. de et al. Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole against strains of fluconazole-resistant Candida parapsilosis. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 5, p. 68-79, may. 2015.2319-7692 (Print)2319-7706 (Online)http://www.repositorio.ufc.br/handle/riufc/17649ark:/83112/001300001kj0pAndrade Neto, João Batista deSilva, Cecília Rocha daCampos, Rosana de SousaNascimento, Francisca Bruna Stefany Aires doSampaio, Letícia SerpaSilva, Anderson R. daSilva, Rose A.C.Freitas, Daniel D. deJosino, Maria AparecidaAndrade, Larissa Nara Dantas deMagalhães, Hemerson Iury FerreiraGaspar, Danielle MacedoMoraes Filho, Manoel Odorico deSilveira, Edilberto R.Gomes, Akenaton Onassis Cardoso VianaCâmara, Claudio A.G.Lima, Iri Sandro PampolhaCavalcanti, Bruno CoêlhoNobre Júnior, Hélio Vitorianoengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-04-18T19:31:08Zoai:repositorio.ufc.br:riufc/17649Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:48:13.703111Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis |
title |
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis |
spellingShingle |
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis Andrade Neto, João Batista de Fluconazol Imunidade Inata Candida |
title_short |
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis |
title_full |
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis |
title_fullStr |
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis |
title_full_unstemmed |
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis |
title_sort |
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole a gainst strains of fluconazole-resistant Candida parapsilosis |
author |
Andrade Neto, João Batista de |
author_facet |
Andrade Neto, João Batista de Silva, Cecília Rocha da Campos, Rosana de Sousa Nascimento, Francisca Bruna Stefany Aires do Sampaio, Letícia Serpa Silva, Anderson R. da Silva, Rose A.C. Freitas, Daniel D. de Josino, Maria Aparecida Andrade, Larissa Nara Dantas de Magalhães, Hemerson Iury Ferreira Gaspar, Danielle Macedo Moraes Filho, Manoel Odorico de Silveira, Edilberto R. Gomes, Akenaton Onassis Cardoso Viana Câmara, Claudio A.G. Lima, Iri Sandro Pampolha Cavalcanti, Bruno Coêlho Nobre Júnior, Hélio Vitoriano |
author_role |
author |
author2 |
Silva, Cecília Rocha da Campos, Rosana de Sousa Nascimento, Francisca Bruna Stefany Aires do Sampaio, Letícia Serpa Silva, Anderson R. da Silva, Rose A.C. Freitas, Daniel D. de Josino, Maria Aparecida Andrade, Larissa Nara Dantas de Magalhães, Hemerson Iury Ferreira Gaspar, Danielle Macedo Moraes Filho, Manoel Odorico de Silveira, Edilberto R. Gomes, Akenaton Onassis Cardoso Viana Câmara, Claudio A.G. Lima, Iri Sandro Pampolha Cavalcanti, Bruno Coêlho Nobre Júnior, Hélio Vitoriano |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade Neto, João Batista de Silva, Cecília Rocha da Campos, Rosana de Sousa Nascimento, Francisca Bruna Stefany Aires do Sampaio, Letícia Serpa Silva, Anderson R. da Silva, Rose A.C. Freitas, Daniel D. de Josino, Maria Aparecida Andrade, Larissa Nara Dantas de Magalhães, Hemerson Iury Ferreira Gaspar, Danielle Macedo Moraes Filho, Manoel Odorico de Silveira, Edilberto R. Gomes, Akenaton Onassis Cardoso Viana Câmara, Claudio A.G. Lima, Iri Sandro Pampolha Cavalcanti, Bruno Coêlho Nobre Júnior, Hélio Vitoriano |
dc.subject.por.fl_str_mv |
Fluconazol Imunidade Inata Candida |
topic |
Fluconazol Imunidade Inata Candida |
description |
Candida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated with a highly mortality rate. Furthermore, antifungal drug resistance (i.e. resistance to azole compounds) is a prominent feature in the management of invasive mycoses, and its epidemiological characteristics continue to evolve. This scenario leads to seek for new candidates for antifungal drugs able to overcome the resistance issues of Candida species. Kaurenoic acid (KA) or ent-kaur-16-en-19-oic acid is a tetracyclic diterpene present in several plants known to exert several pharmacological activities such cytotoxic actions and antimicrobial in vitro. The aim of current study was evaluate the potential antifungal of the natural diterpenoids kauren-19-oic acid (KA), 14-hydroxy-kaurane (1) and xylopic acid (2), and semi-synthetic derivatives of KA (3-5) towards Candida parapsilosis. Six combinations formed by different diterpenoids kauren-19-oic acid (KA), compounds (1-5), were tested using varied fluconazole concentration. We concluded that the compound 4 (16 -methoxy-( )-kauran-19-oic methylester) when combined with fluconazole, show activity against strains of C. parapsilosis resistant to fluconazole. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-05 2016-06-14T15:44:37Z 2016-06-14T15:44:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ANDRADE NETO, J. B. de et al. Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole against strains of fluconazole-resistant Candida parapsilosis. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 5, p. 68-79, may. 2015. 2319-7692 (Print) 2319-7706 (Online) http://www.repositorio.ufc.br/handle/riufc/17649 |
dc.identifier.dark.fl_str_mv |
ark:/83112/001300001kj0p |
identifier_str_mv |
ANDRADE NETO, J. B. de et al. Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole against strains of fluconazole-resistant Candida parapsilosis. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 5, p. 68-79, may. 2015. 2319-7692 (Print) 2319-7706 (Online) ark:/83112/001300001kj0p |
url |
http://www.repositorio.ufc.br/handle/riufc/17649 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
International Journal of Current Microbiology and Applied Sciences |
publisher.none.fl_str_mv |
International Journal of Current Microbiology and Applied Sciences |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1818373978549387264 |