Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/9420 |
Resumo: | OBJECTIVE: This study was conducted to investigate factors associated with thrombocytopenia in a large cohort of patients with leptospirosis in an endemic area. METHODS: This retrospective study included 374 consecutive patients with leptospirosis who were admitted to tertiary hospitals in Fortaleza, Brazil. All patients had a diagnosis of severe leptospirosis (Weil’s disease). Acute kidney injury was defined according to the RIFLE criteria. Thrombocytopenia was defined as a platelet count ,100,000/mm3. RESULTS: A total of 374 patients were included, with a mean age of 36.1¡15.5 years, and 83.4% were male. Thrombocytopenia was present at the time of hospital admission in 200 cases (53.5%), and it developed during the hospital stay in 150 cases (40.3%). The patients with thrombocytopenia had higher frequencies of dehydration (53% vs. 35.3%, p = 0.001), epistaxis (5.7% vs. 0.8%, p = 0.033), hematemesis (13% vs. 4.6%, p = 0.006), myalgia (91.5% vs. 84.5%, p = 0.038), hematuria (54.8% vs. 37.6%, p = 0.011), metabolic acidosis (18% vs. 9.2%, p = 0.016) and hypoalbuminemia (17.8% vs. 7.5%, p = 0.005). The independent risk factors associated with thrombocytopenia during the hospital stay were lengthy disease (OR: 1.2, p = 0.001) and acute kidney injury (OR: 6.6, p = 0.004). Mortality was not associated with thrombocytopenia at admission (12.5% vs. 12.6%, p = 1.000) or during the hospital stay (12.6% vs. 11.3%, p = 0.748). CONCLUSIONS: Thrombocytopenia is a frequent complication in leptospirosis, and this condition was present in more than half of patients at the time of hospital admission. Lengthy disease and acute kidney injury are risk factors for thrombocytopenia. There was no significant association between thrombocytopenia and mortality. |
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Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)LeptospiroseTrombocitopeniaOBJECTIVE: This study was conducted to investigate factors associated with thrombocytopenia in a large cohort of patients with leptospirosis in an endemic area. METHODS: This retrospective study included 374 consecutive patients with leptospirosis who were admitted to tertiary hospitals in Fortaleza, Brazil. All patients had a diagnosis of severe leptospirosis (Weil’s disease). Acute kidney injury was defined according to the RIFLE criteria. Thrombocytopenia was defined as a platelet count ,100,000/mm3. RESULTS: A total of 374 patients were included, with a mean age of 36.1¡15.5 years, and 83.4% were male. Thrombocytopenia was present at the time of hospital admission in 200 cases (53.5%), and it developed during the hospital stay in 150 cases (40.3%). The patients with thrombocytopenia had higher frequencies of dehydration (53% vs. 35.3%, p = 0.001), epistaxis (5.7% vs. 0.8%, p = 0.033), hematemesis (13% vs. 4.6%, p = 0.006), myalgia (91.5% vs. 84.5%, p = 0.038), hematuria (54.8% vs. 37.6%, p = 0.011), metabolic acidosis (18% vs. 9.2%, p = 0.016) and hypoalbuminemia (17.8% vs. 7.5%, p = 0.005). The independent risk factors associated with thrombocytopenia during the hospital stay were lengthy disease (OR: 1.2, p = 0.001) and acute kidney injury (OR: 6.6, p = 0.004). Mortality was not associated with thrombocytopenia at admission (12.5% vs. 12.6%, p = 1.000) or during the hospital stay (12.6% vs. 11.3%, p = 0.748). CONCLUSIONS: Thrombocytopenia is a frequent complication in leptospirosis, and this condition was present in more than half of patients at the time of hospital admission. Lengthy disease and acute kidney injury are risk factors for thrombocytopenia. There was no significant association between thrombocytopenia and mortality.2014-10-14T14:32:53Z2014-10-14T14:32:53Z2014-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfDAHER, E. F. et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics, São Paulo, v. 69, n. 2, p. 106-110, fev., 2014.1807-5932 Printhttp://www.repositorio.ufc.br/handle/riufc/9420Daher, Elizabeth de FrancescoSilva Junior, Geraldo B.Silveira, Charles O.Falcão, Felipe S.Alves, Marília P.Mota, Jório A. A. A.Lima, Joyce B.Mota, Rosa M. S.Vieira, Ana Patrícia F.Pires Neto, Roberto da JustaLibório, Alexandre B.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-03-04T19:34:09Zoai:repositorio.ufc.br:riufc/9420Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:47:40.933832Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease) |
title |
Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease) |
spellingShingle |
Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease) Daher, Elizabeth de Francesco Leptospirose Trombocitopenia |
title_short |
Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease) |
title_full |
Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease) |
title_fullStr |
Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease) |
title_full_unstemmed |
Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease) |
title_sort |
Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease) |
author |
Daher, Elizabeth de Francesco |
author_facet |
Daher, Elizabeth de Francesco Silva Junior, Geraldo B. Silveira, Charles O. Falcão, Felipe S. Alves, Marília P. Mota, Jório A. A. A. Lima, Joyce B. Mota, Rosa M. S. Vieira, Ana Patrícia F. Pires Neto, Roberto da Justa Libório, Alexandre B. |
author_role |
author |
author2 |
Silva Junior, Geraldo B. Silveira, Charles O. Falcão, Felipe S. Alves, Marília P. Mota, Jório A. A. A. Lima, Joyce B. Mota, Rosa M. S. Vieira, Ana Patrícia F. Pires Neto, Roberto da Justa Libório, Alexandre B. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Daher, Elizabeth de Francesco Silva Junior, Geraldo B. Silveira, Charles O. Falcão, Felipe S. Alves, Marília P. Mota, Jório A. A. A. Lima, Joyce B. Mota, Rosa M. S. Vieira, Ana Patrícia F. Pires Neto, Roberto da Justa Libório, Alexandre B. |
dc.subject.por.fl_str_mv |
Leptospirose Trombocitopenia |
topic |
Leptospirose Trombocitopenia |
description |
OBJECTIVE: This study was conducted to investigate factors associated with thrombocytopenia in a large cohort of patients with leptospirosis in an endemic area. METHODS: This retrospective study included 374 consecutive patients with leptospirosis who were admitted to tertiary hospitals in Fortaleza, Brazil. All patients had a diagnosis of severe leptospirosis (Weil’s disease). Acute kidney injury was defined according to the RIFLE criteria. Thrombocytopenia was defined as a platelet count ,100,000/mm3. RESULTS: A total of 374 patients were included, with a mean age of 36.1¡15.5 years, and 83.4% were male. Thrombocytopenia was present at the time of hospital admission in 200 cases (53.5%), and it developed during the hospital stay in 150 cases (40.3%). The patients with thrombocytopenia had higher frequencies of dehydration (53% vs. 35.3%, p = 0.001), epistaxis (5.7% vs. 0.8%, p = 0.033), hematemesis (13% vs. 4.6%, p = 0.006), myalgia (91.5% vs. 84.5%, p = 0.038), hematuria (54.8% vs. 37.6%, p = 0.011), metabolic acidosis (18% vs. 9.2%, p = 0.016) and hypoalbuminemia (17.8% vs. 7.5%, p = 0.005). The independent risk factors associated with thrombocytopenia during the hospital stay were lengthy disease (OR: 1.2, p = 0.001) and acute kidney injury (OR: 6.6, p = 0.004). Mortality was not associated with thrombocytopenia at admission (12.5% vs. 12.6%, p = 1.000) or during the hospital stay (12.6% vs. 11.3%, p = 0.748). CONCLUSIONS: Thrombocytopenia is a frequent complication in leptospirosis, and this condition was present in more than half of patients at the time of hospital admission. Lengthy disease and acute kidney injury are risk factors for thrombocytopenia. There was no significant association between thrombocytopenia and mortality. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-14T14:32:53Z 2014-10-14T14:32:53Z 2014-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
DAHER, E. F. et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics, São Paulo, v. 69, n. 2, p. 106-110, fev., 2014. 1807-5932 Print http://www.repositorio.ufc.br/handle/riufc/9420 |
identifier_str_mv |
DAHER, E. F. et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics, São Paulo, v. 69, n. 2, p. 106-110, fev., 2014. 1807-5932 Print |
url |
http://www.repositorio.ufc.br/handle/riufc/9420 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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1813028948723892224 |