Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)

Detalhes bibliográficos
Autor(a) principal: Daher, Elizabeth de Francesco
Data de Publicação: 2014
Outros Autores: Silva Junior, Geraldo B., Silveira, Charles O., Falcão, Felipe S., Alves, Marília P., Mota, Jório A. A. A., Lima, Joyce B., Mota, Rosa M. S., Vieira, Ana Patrícia F., Pires Neto, Roberto da Justa, Libório, Alexandre B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/9420
Resumo: OBJECTIVE: This study was conducted to investigate factors associated with thrombocytopenia in a large cohort of patients with leptospirosis in an endemic area. METHODS: This retrospective study included 374 consecutive patients with leptospirosis who were admitted to tertiary hospitals in Fortaleza, Brazil. All patients had a diagnosis of severe leptospirosis (Weil’s disease). Acute kidney injury was defined according to the RIFLE criteria. Thrombocytopenia was defined as a platelet count ,100,000/mm3. RESULTS: A total of 374 patients were included, with a mean age of 36.1¡15.5 years, and 83.4% were male. Thrombocytopenia was present at the time of hospital admission in 200 cases (53.5%), and it developed during the hospital stay in 150 cases (40.3%). The patients with thrombocytopenia had higher frequencies of dehydration (53% vs. 35.3%, p = 0.001), epistaxis (5.7% vs. 0.8%, p = 0.033), hematemesis (13% vs. 4.6%, p = 0.006), myalgia (91.5% vs. 84.5%, p = 0.038), hematuria (54.8% vs. 37.6%, p = 0.011), metabolic acidosis (18% vs. 9.2%, p = 0.016) and hypoalbuminemia (17.8% vs. 7.5%, p = 0.005). The independent risk factors associated with thrombocytopenia during the hospital stay were lengthy disease (OR: 1.2, p = 0.001) and acute kidney injury (OR: 6.6, p = 0.004). Mortality was not associated with thrombocytopenia at admission (12.5% vs. 12.6%, p = 1.000) or during the hospital stay (12.6% vs. 11.3%, p = 0.748). CONCLUSIONS: Thrombocytopenia is a frequent complication in leptospirosis, and this condition was present in more than half of patients at the time of hospital admission. Lengthy disease and acute kidney injury are risk factors for thrombocytopenia. There was no significant association between thrombocytopenia and mortality.
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spelling Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)LeptospiroseTrombocitopeniaOBJECTIVE: This study was conducted to investigate factors associated with thrombocytopenia in a large cohort of patients with leptospirosis in an endemic area. METHODS: This retrospective study included 374 consecutive patients with leptospirosis who were admitted to tertiary hospitals in Fortaleza, Brazil. All patients had a diagnosis of severe leptospirosis (Weil’s disease). Acute kidney injury was defined according to the RIFLE criteria. Thrombocytopenia was defined as a platelet count ,100,000/mm3. RESULTS: A total of 374 patients were included, with a mean age of 36.1¡15.5 years, and 83.4% were male. Thrombocytopenia was present at the time of hospital admission in 200 cases (53.5%), and it developed during the hospital stay in 150 cases (40.3%). The patients with thrombocytopenia had higher frequencies of dehydration (53% vs. 35.3%, p = 0.001), epistaxis (5.7% vs. 0.8%, p = 0.033), hematemesis (13% vs. 4.6%, p = 0.006), myalgia (91.5% vs. 84.5%, p = 0.038), hematuria (54.8% vs. 37.6%, p = 0.011), metabolic acidosis (18% vs. 9.2%, p = 0.016) and hypoalbuminemia (17.8% vs. 7.5%, p = 0.005). The independent risk factors associated with thrombocytopenia during the hospital stay were lengthy disease (OR: 1.2, p = 0.001) and acute kidney injury (OR: 6.6, p = 0.004). Mortality was not associated with thrombocytopenia at admission (12.5% vs. 12.6%, p = 1.000) or during the hospital stay (12.6% vs. 11.3%, p = 0.748). CONCLUSIONS: Thrombocytopenia is a frequent complication in leptospirosis, and this condition was present in more than half of patients at the time of hospital admission. Lengthy disease and acute kidney injury are risk factors for thrombocytopenia. There was no significant association between thrombocytopenia and mortality.2014-10-14T14:32:53Z2014-10-14T14:32:53Z2014-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfDAHER, E. F. et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics, São Paulo, v. 69, n. 2, p. 106-110, fev., 2014.1807-5932 Printhttp://www.repositorio.ufc.br/handle/riufc/9420Daher, Elizabeth de FrancescoSilva Junior, Geraldo B.Silveira, Charles O.Falcão, Felipe S.Alves, Marília P.Mota, Jório A. A. A.Lima, Joyce B.Mota, Rosa M. S.Vieira, Ana Patrícia F.Pires Neto, Roberto da JustaLibório, Alexandre B.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-03-04T19:34:09Zoai:repositorio.ufc.br:riufc/9420Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:47:40.933832Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
title Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
spellingShingle Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
Daher, Elizabeth de Francesco
Leptospirose
Trombocitopenia
title_short Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
title_full Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
title_fullStr Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
title_full_unstemmed Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
title_sort Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease)
author Daher, Elizabeth de Francesco
author_facet Daher, Elizabeth de Francesco
Silva Junior, Geraldo B.
Silveira, Charles O.
Falcão, Felipe S.
Alves, Marília P.
Mota, Jório A. A. A.
Lima, Joyce B.
Mota, Rosa M. S.
Vieira, Ana Patrícia F.
Pires Neto, Roberto da Justa
Libório, Alexandre B.
author_role author
author2 Silva Junior, Geraldo B.
Silveira, Charles O.
Falcão, Felipe S.
Alves, Marília P.
Mota, Jório A. A. A.
Lima, Joyce B.
Mota, Rosa M. S.
Vieira, Ana Patrícia F.
Pires Neto, Roberto da Justa
Libório, Alexandre B.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Daher, Elizabeth de Francesco
Silva Junior, Geraldo B.
Silveira, Charles O.
Falcão, Felipe S.
Alves, Marília P.
Mota, Jório A. A. A.
Lima, Joyce B.
Mota, Rosa M. S.
Vieira, Ana Patrícia F.
Pires Neto, Roberto da Justa
Libório, Alexandre B.
dc.subject.por.fl_str_mv Leptospirose
Trombocitopenia
topic Leptospirose
Trombocitopenia
description OBJECTIVE: This study was conducted to investigate factors associated with thrombocytopenia in a large cohort of patients with leptospirosis in an endemic area. METHODS: This retrospective study included 374 consecutive patients with leptospirosis who were admitted to tertiary hospitals in Fortaleza, Brazil. All patients had a diagnosis of severe leptospirosis (Weil’s disease). Acute kidney injury was defined according to the RIFLE criteria. Thrombocytopenia was defined as a platelet count ,100,000/mm3. RESULTS: A total of 374 patients were included, with a mean age of 36.1¡15.5 years, and 83.4% were male. Thrombocytopenia was present at the time of hospital admission in 200 cases (53.5%), and it developed during the hospital stay in 150 cases (40.3%). The patients with thrombocytopenia had higher frequencies of dehydration (53% vs. 35.3%, p = 0.001), epistaxis (5.7% vs. 0.8%, p = 0.033), hematemesis (13% vs. 4.6%, p = 0.006), myalgia (91.5% vs. 84.5%, p = 0.038), hematuria (54.8% vs. 37.6%, p = 0.011), metabolic acidosis (18% vs. 9.2%, p = 0.016) and hypoalbuminemia (17.8% vs. 7.5%, p = 0.005). The independent risk factors associated with thrombocytopenia during the hospital stay were lengthy disease (OR: 1.2, p = 0.001) and acute kidney injury (OR: 6.6, p = 0.004). Mortality was not associated with thrombocytopenia at admission (12.5% vs. 12.6%, p = 1.000) or during the hospital stay (12.6% vs. 11.3%, p = 0.748). CONCLUSIONS: Thrombocytopenia is a frequent complication in leptospirosis, and this condition was present in more than half of patients at the time of hospital admission. Lengthy disease and acute kidney injury are risk factors for thrombocytopenia. There was no significant association between thrombocytopenia and mortality.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-14T14:32:53Z
2014-10-14T14:32:53Z
2014-02
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv DAHER, E. F. et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics, São Paulo, v. 69, n. 2, p. 106-110, fev., 2014.
1807-5932 Print
http://www.repositorio.ufc.br/handle/riufc/9420
identifier_str_mv DAHER, E. F. et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics, São Paulo, v. 69, n. 2, p. 106-110, fev., 2014.
1807-5932 Print
url http://www.repositorio.ufc.br/handle/riufc/9420
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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