Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review

Detalhes bibliográficos
Autor(a) principal: Aguiar, Gabriella Pequeno Costa Gomes de
Data de Publicação: 2019
Outros Autores: Leite, Claudio Manuel Gonçalves da Silva, Dias, Beatriz, Vasconcelos, Silvania Maria Mendes, Moraes, Renata Amaral de, Moraes, Maria Elisabete Amaral de, Vallinoto, Antonio Carlos Rosario, Macedo, Danielle Silveira, Cavalcanti, Luciano Pamplona de Goes, Miyajima, Fabio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/45669
Resumo: Background: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. We set to systematically review all published evidence describing any epigenetic modifications associated with infections from arboviruses, including, but not limited to, microRNAs, DNA methylation, and histone modifications. Methods: A comprehensive search was conducted using the electronic databases PubMed, Science Direct and Cochrane Library from inception to January 4th, 2018. We included reports describing original in vivo or in vitro studies investigating epigenetic changes related to arbovirus infections in either clinical subjects or human cell lines. Studies investigating epigenetic modifications related to the virus or the arthropod vector were excluded. A narrative synthesis of the findings was conducted, contextualizing comparative evidence from in vitro and in vivo studies. Results: A total of 853 unique references were identified and screened by two independent researchers. Thirty-two studiesmet the inclusion criteria and were reviewed. The evidence was centered mainly on microRNA and DNA methylation signatures implicated with secondary Dengue fever. Evidence for recent epidemic threats, such as the infections by Zika or Chikungunya viruses is still scant. Conclusions: Major epigenetic alterations found on arboviruses infections were miR-146, miR-30e and the Dicer complex. However, existing studies frequently tested distinct hypotheses resulting in a heterogeneity of methodological approaches. Whilst epigenetic signatures associated with arbovirus infections have been reported, existing studies have largely focused on a small number of diseases, particularly dengue. Validation of epigenetic signatures have an untapped potential, but concerted investigations are certainly required to deliver robust candidates of clinical utility for diagnosis, staging and prognosis of specific arboviral diseases.
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spelling Evidence for host epigenetic signatures arising from arbovirus infections: a systematic reviewRevisão SistemáticaSystematic ReviewEpigenômicaEpigenomicsMicroRNAsHistonasArbovirusBackground: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. We set to systematically review all published evidence describing any epigenetic modifications associated with infections from arboviruses, including, but not limited to, microRNAs, DNA methylation, and histone modifications. Methods: A comprehensive search was conducted using the electronic databases PubMed, Science Direct and Cochrane Library from inception to January 4th, 2018. We included reports describing original in vivo or in vitro studies investigating epigenetic changes related to arbovirus infections in either clinical subjects or human cell lines. Studies investigating epigenetic modifications related to the virus or the arthropod vector were excluded. A narrative synthesis of the findings was conducted, contextualizing comparative evidence from in vitro and in vivo studies. Results: A total of 853 unique references were identified and screened by two independent researchers. Thirty-two studiesmet the inclusion criteria and were reviewed. The evidence was centered mainly on microRNA and DNA methylation signatures implicated with secondary Dengue fever. Evidence for recent epidemic threats, such as the infections by Zika or Chikungunya viruses is still scant. Conclusions: Major epigenetic alterations found on arboviruses infections were miR-146, miR-30e and the Dicer complex. However, existing studies frequently tested distinct hypotheses resulting in a heterogeneity of methodological approaches. Whilst epigenetic signatures associated with arbovirus infections have been reported, existing studies have largely focused on a small number of diseases, particularly dengue. Validation of epigenetic signatures have an untapped potential, but concerted investigations are certainly required to deliver robust candidates of clinical utility for diagnosis, staging and prognosis of specific arboviral diseases.Frontiers in Immunology2019-09-11T14:30:58Z2019-09-11T14:30:58Z2019-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAGUIAR, Gabriella Pequeno Costa Gomes de et al. Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review. Frontiers in Immunology, v. 10, p. 10-15, may, 2019.1664-3224 (On line)http://www.repositorio.ufc.br/handle/riufc/45669Aguiar, Gabriella Pequeno Costa Gomes deLeite, Claudio Manuel Gonçalves da SilvaDias, BeatrizVasconcelos, Silvania Maria MendesMoraes, Renata Amaral deMoraes, Maria Elisabete Amaral deVallinoto, Antonio Carlos RosarioMacedo, Danielle SilveiraCavalcanti, Luciano Pamplona de GoesMiyajima, Fabioengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-10-16T13:18:57Zoai:repositorio.ufc.br:riufc/45669Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:35:28.860660Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
title Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
spellingShingle Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
Aguiar, Gabriella Pequeno Costa Gomes de
Revisão Sistemática
Systematic Review
Epigenômica
Epigenomics
MicroRNAs
Histonas
Arbovirus
title_short Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
title_full Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
title_fullStr Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
title_full_unstemmed Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
title_sort Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
author Aguiar, Gabriella Pequeno Costa Gomes de
author_facet Aguiar, Gabriella Pequeno Costa Gomes de
Leite, Claudio Manuel Gonçalves da Silva
Dias, Beatriz
Vasconcelos, Silvania Maria Mendes
Moraes, Renata Amaral de
Moraes, Maria Elisabete Amaral de
Vallinoto, Antonio Carlos Rosario
Macedo, Danielle Silveira
Cavalcanti, Luciano Pamplona de Goes
Miyajima, Fabio
author_role author
author2 Leite, Claudio Manuel Gonçalves da Silva
Dias, Beatriz
Vasconcelos, Silvania Maria Mendes
Moraes, Renata Amaral de
Moraes, Maria Elisabete Amaral de
Vallinoto, Antonio Carlos Rosario
Macedo, Danielle Silveira
Cavalcanti, Luciano Pamplona de Goes
Miyajima, Fabio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Aguiar, Gabriella Pequeno Costa Gomes de
Leite, Claudio Manuel Gonçalves da Silva
Dias, Beatriz
Vasconcelos, Silvania Maria Mendes
Moraes, Renata Amaral de
Moraes, Maria Elisabete Amaral de
Vallinoto, Antonio Carlos Rosario
Macedo, Danielle Silveira
Cavalcanti, Luciano Pamplona de Goes
Miyajima, Fabio
dc.subject.por.fl_str_mv Revisão Sistemática
Systematic Review
Epigenômica
Epigenomics
MicroRNAs
Histonas
Arbovirus
topic Revisão Sistemática
Systematic Review
Epigenômica
Epigenomics
MicroRNAs
Histonas
Arbovirus
description Background: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. We set to systematically review all published evidence describing any epigenetic modifications associated with infections from arboviruses, including, but not limited to, microRNAs, DNA methylation, and histone modifications. Methods: A comprehensive search was conducted using the electronic databases PubMed, Science Direct and Cochrane Library from inception to January 4th, 2018. We included reports describing original in vivo or in vitro studies investigating epigenetic changes related to arbovirus infections in either clinical subjects or human cell lines. Studies investigating epigenetic modifications related to the virus or the arthropod vector were excluded. A narrative synthesis of the findings was conducted, contextualizing comparative evidence from in vitro and in vivo studies. Results: A total of 853 unique references were identified and screened by two independent researchers. Thirty-two studiesmet the inclusion criteria and were reviewed. The evidence was centered mainly on microRNA and DNA methylation signatures implicated with secondary Dengue fever. Evidence for recent epidemic threats, such as the infections by Zika or Chikungunya viruses is still scant. Conclusions: Major epigenetic alterations found on arboviruses infections were miR-146, miR-30e and the Dicer complex. However, existing studies frequently tested distinct hypotheses resulting in a heterogeneity of methodological approaches. Whilst epigenetic signatures associated with arbovirus infections have been reported, existing studies have largely focused on a small number of diseases, particularly dengue. Validation of epigenetic signatures have an untapped potential, but concerted investigations are certainly required to deliver robust candidates of clinical utility for diagnosis, staging and prognosis of specific arboviral diseases.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-11T14:30:58Z
2019-09-11T14:30:58Z
2019-05
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv AGUIAR, Gabriella Pequeno Costa Gomes de et al. Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review. Frontiers in Immunology, v. 10, p. 10-15, may, 2019.
1664-3224 (On line)
http://www.repositorio.ufc.br/handle/riufc/45669
identifier_str_mv AGUIAR, Gabriella Pequeno Costa Gomes de et al. Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review. Frontiers in Immunology, v. 10, p. 10-15, may, 2019.
1664-3224 (On line)
url http://www.repositorio.ufc.br/handle/riufc/45669
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers in Immunology
publisher.none.fl_str_mv Frontiers in Immunology
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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