Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/45669 |
Resumo: | Background: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. We set to systematically review all published evidence describing any epigenetic modifications associated with infections from arboviruses, including, but not limited to, microRNAs, DNA methylation, and histone modifications. Methods: A comprehensive search was conducted using the electronic databases PubMed, Science Direct and Cochrane Library from inception to January 4th, 2018. We included reports describing original in vivo or in vitro studies investigating epigenetic changes related to arbovirus infections in either clinical subjects or human cell lines. Studies investigating epigenetic modifications related to the virus or the arthropod vector were excluded. A narrative synthesis of the findings was conducted, contextualizing comparative evidence from in vitro and in vivo studies. Results: A total of 853 unique references were identified and screened by two independent researchers. Thirty-two studiesmet the inclusion criteria and were reviewed. The evidence was centered mainly on microRNA and DNA methylation signatures implicated with secondary Dengue fever. Evidence for recent epidemic threats, such as the infections by Zika or Chikungunya viruses is still scant. Conclusions: Major epigenetic alterations found on arboviruses infections were miR-146, miR-30e and the Dicer complex. However, existing studies frequently tested distinct hypotheses resulting in a heterogeneity of methodological approaches. Whilst epigenetic signatures associated with arbovirus infections have been reported, existing studies have largely focused on a small number of diseases, particularly dengue. Validation of epigenetic signatures have an untapped potential, but concerted investigations are certainly required to deliver robust candidates of clinical utility for diagnosis, staging and prognosis of specific arboviral diseases. |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Evidence for host epigenetic signatures arising from arbovirus infections: a systematic reviewRevisão SistemáticaSystematic ReviewEpigenômicaEpigenomicsMicroRNAsHistonasArbovirusBackground: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. We set to systematically review all published evidence describing any epigenetic modifications associated with infections from arboviruses, including, but not limited to, microRNAs, DNA methylation, and histone modifications. Methods: A comprehensive search was conducted using the electronic databases PubMed, Science Direct and Cochrane Library from inception to January 4th, 2018. We included reports describing original in vivo or in vitro studies investigating epigenetic changes related to arbovirus infections in either clinical subjects or human cell lines. Studies investigating epigenetic modifications related to the virus or the arthropod vector were excluded. A narrative synthesis of the findings was conducted, contextualizing comparative evidence from in vitro and in vivo studies. Results: A total of 853 unique references were identified and screened by two independent researchers. Thirty-two studiesmet the inclusion criteria and were reviewed. The evidence was centered mainly on microRNA and DNA methylation signatures implicated with secondary Dengue fever. Evidence for recent epidemic threats, such as the infections by Zika or Chikungunya viruses is still scant. Conclusions: Major epigenetic alterations found on arboviruses infections were miR-146, miR-30e and the Dicer complex. However, existing studies frequently tested distinct hypotheses resulting in a heterogeneity of methodological approaches. Whilst epigenetic signatures associated with arbovirus infections have been reported, existing studies have largely focused on a small number of diseases, particularly dengue. Validation of epigenetic signatures have an untapped potential, but concerted investigations are certainly required to deliver robust candidates of clinical utility for diagnosis, staging and prognosis of specific arboviral diseases.Frontiers in Immunology2019-09-11T14:30:58Z2019-09-11T14:30:58Z2019-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAGUIAR, Gabriella Pequeno Costa Gomes de et al. Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review. Frontiers in Immunology, v. 10, p. 10-15, may, 2019.1664-3224 (On line)http://www.repositorio.ufc.br/handle/riufc/45669Aguiar, Gabriella Pequeno Costa Gomes deLeite, Claudio Manuel Gonçalves da SilvaDias, BeatrizVasconcelos, Silvania Maria MendesMoraes, Renata Amaral deMoraes, Maria Elisabete Amaral deVallinoto, Antonio Carlos RosarioMacedo, Danielle SilveiraCavalcanti, Luciano Pamplona de GoesMiyajima, Fabioengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-10-16T13:18:57Zoai:repositorio.ufc.br:riufc/45669Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:35:28.860660Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review |
title |
Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review |
spellingShingle |
Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review Aguiar, Gabriella Pequeno Costa Gomes de Revisão Sistemática Systematic Review Epigenômica Epigenomics MicroRNAs Histonas Arbovirus |
title_short |
Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review |
title_full |
Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review |
title_fullStr |
Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review |
title_full_unstemmed |
Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review |
title_sort |
Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review |
author |
Aguiar, Gabriella Pequeno Costa Gomes de |
author_facet |
Aguiar, Gabriella Pequeno Costa Gomes de Leite, Claudio Manuel Gonçalves da Silva Dias, Beatriz Vasconcelos, Silvania Maria Mendes Moraes, Renata Amaral de Moraes, Maria Elisabete Amaral de Vallinoto, Antonio Carlos Rosario Macedo, Danielle Silveira Cavalcanti, Luciano Pamplona de Goes Miyajima, Fabio |
author_role |
author |
author2 |
Leite, Claudio Manuel Gonçalves da Silva Dias, Beatriz Vasconcelos, Silvania Maria Mendes Moraes, Renata Amaral de Moraes, Maria Elisabete Amaral de Vallinoto, Antonio Carlos Rosario Macedo, Danielle Silveira Cavalcanti, Luciano Pamplona de Goes Miyajima, Fabio |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Aguiar, Gabriella Pequeno Costa Gomes de Leite, Claudio Manuel Gonçalves da Silva Dias, Beatriz Vasconcelos, Silvania Maria Mendes Moraes, Renata Amaral de Moraes, Maria Elisabete Amaral de Vallinoto, Antonio Carlos Rosario Macedo, Danielle Silveira Cavalcanti, Luciano Pamplona de Goes Miyajima, Fabio |
dc.subject.por.fl_str_mv |
Revisão Sistemática Systematic Review Epigenômica Epigenomics MicroRNAs Histonas Arbovirus |
topic |
Revisão Sistemática Systematic Review Epigenômica Epigenomics MicroRNAs Histonas Arbovirus |
description |
Background: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. We set to systematically review all published evidence describing any epigenetic modifications associated with infections from arboviruses, including, but not limited to, microRNAs, DNA methylation, and histone modifications. Methods: A comprehensive search was conducted using the electronic databases PubMed, Science Direct and Cochrane Library from inception to January 4th, 2018. We included reports describing original in vivo or in vitro studies investigating epigenetic changes related to arbovirus infections in either clinical subjects or human cell lines. Studies investigating epigenetic modifications related to the virus or the arthropod vector were excluded. A narrative synthesis of the findings was conducted, contextualizing comparative evidence from in vitro and in vivo studies. Results: A total of 853 unique references were identified and screened by two independent researchers. Thirty-two studiesmet the inclusion criteria and were reviewed. The evidence was centered mainly on microRNA and DNA methylation signatures implicated with secondary Dengue fever. Evidence for recent epidemic threats, such as the infections by Zika or Chikungunya viruses is still scant. Conclusions: Major epigenetic alterations found on arboviruses infections were miR-146, miR-30e and the Dicer complex. However, existing studies frequently tested distinct hypotheses resulting in a heterogeneity of methodological approaches. Whilst epigenetic signatures associated with arbovirus infections have been reported, existing studies have largely focused on a small number of diseases, particularly dengue. Validation of epigenetic signatures have an untapped potential, but concerted investigations are certainly required to deliver robust candidates of clinical utility for diagnosis, staging and prognosis of specific arboviral diseases. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-11T14:30:58Z 2019-09-11T14:30:58Z 2019-05 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
AGUIAR, Gabriella Pequeno Costa Gomes de et al. Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review. Frontiers in Immunology, v. 10, p. 10-15, may, 2019. 1664-3224 (On line) http://www.repositorio.ufc.br/handle/riufc/45669 |
identifier_str_mv |
AGUIAR, Gabriella Pequeno Costa Gomes de et al. Evidence for host epigenetic signatures arising from arbovirus infections: a systematic review. Frontiers in Immunology, v. 10, p. 10-15, may, 2019. 1664-3224 (On line) |
url |
http://www.repositorio.ufc.br/handle/riufc/45669 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers in Immunology |
publisher.none.fl_str_mv |
Frontiers in Immunology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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