Atrial stretch delays gastric emptying of liquids in awake rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/5688 |
Resumo: | Aims: We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Main methods: Anesthetizedmale rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day,mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20 min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70 μl saline for 5 min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30 min later. Key findings: Heart rate and CVP valueswere transiently increased by 50 or 70 μl AS but not 30 μl AS, whereas gastric emptying was slower after 30, 50, or 70 μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it. Significance: Atrial stretch inhibited the gastric emptying. |
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Atrial stretch delays gastric emptying of liquids in awake ratsÓxido NítricoRatosAims: We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Main methods: Anesthetizedmale rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day,mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20 min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70 μl saline for 5 min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30 min later. Key findings: Heart rate and CVP valueswere transiently increased by 50 or 70 μl AS but not 30 μl AS, whereas gastric emptying was slower after 30, 50, or 70 μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it. Significance: Atrial stretch inhibited the gastric emptying.Life Sciences2013-08-26T15:24:28Z2013-08-26T15:24:28Z2013-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPALHETA JR., R.C. et al. Atrial stretch delays gastric emptying of liquids in awake rats. Life sciences, Elmsford, NY, v. 92, n. 10, p. 569-575, mar. 2013.0024-3205http://www.repositorio.ufc.br/handle/riufc/5688Palheta Júnior, Raimundo CamposSilva, Moisés Tolentino Bento daBarbosa, H. L. G.Pinheiro, Ana Débora NunesCardoso, KKátia Virgínia VianaGraça, José Ronaldo Vasconcelos daMagalhães, Pedro Jorge CaldasOliveira, Ricardo Brandt deSantos, Armênio Aguiar dosengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-05-04T18:14:20Zoai:repositorio.ufc.br:riufc/5688Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T19:00:02.830368Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Atrial stretch delays gastric emptying of liquids in awake rats |
title |
Atrial stretch delays gastric emptying of liquids in awake rats |
spellingShingle |
Atrial stretch delays gastric emptying of liquids in awake rats Palheta Júnior, Raimundo Campos Óxido Nítrico Ratos |
title_short |
Atrial stretch delays gastric emptying of liquids in awake rats |
title_full |
Atrial stretch delays gastric emptying of liquids in awake rats |
title_fullStr |
Atrial stretch delays gastric emptying of liquids in awake rats |
title_full_unstemmed |
Atrial stretch delays gastric emptying of liquids in awake rats |
title_sort |
Atrial stretch delays gastric emptying of liquids in awake rats |
author |
Palheta Júnior, Raimundo Campos |
author_facet |
Palheta Júnior, Raimundo Campos Silva, Moisés Tolentino Bento da Barbosa, H. L. G. Pinheiro, Ana Débora Nunes Cardoso, KKátia Virgínia Viana Graça, José Ronaldo Vasconcelos da Magalhães, Pedro Jorge Caldas Oliveira, Ricardo Brandt de Santos, Armênio Aguiar dos |
author_role |
author |
author2 |
Silva, Moisés Tolentino Bento da Barbosa, H. L. G. Pinheiro, Ana Débora Nunes Cardoso, KKátia Virgínia Viana Graça, José Ronaldo Vasconcelos da Magalhães, Pedro Jorge Caldas Oliveira, Ricardo Brandt de Santos, Armênio Aguiar dos |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Palheta Júnior, Raimundo Campos Silva, Moisés Tolentino Bento da Barbosa, H. L. G. Pinheiro, Ana Débora Nunes Cardoso, KKátia Virgínia Viana Graça, José Ronaldo Vasconcelos da Magalhães, Pedro Jorge Caldas Oliveira, Ricardo Brandt de Santos, Armênio Aguiar dos |
dc.subject.por.fl_str_mv |
Óxido Nítrico Ratos |
topic |
Óxido Nítrico Ratos |
description |
Aims: We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Main methods: Anesthetizedmale rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day,mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20 min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70 μl saline for 5 min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30 min later. Key findings: Heart rate and CVP valueswere transiently increased by 50 or 70 μl AS but not 30 μl AS, whereas gastric emptying was slower after 30, 50, or 70 μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it. Significance: Atrial stretch inhibited the gastric emptying. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-08-26T15:24:28Z 2013-08-26T15:24:28Z 2013-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
PALHETA JR., R.C. et al. Atrial stretch delays gastric emptying of liquids in awake rats. Life sciences, Elmsford, NY, v. 92, n. 10, p. 569-575, mar. 2013. 0024-3205 http://www.repositorio.ufc.br/handle/riufc/5688 |
identifier_str_mv |
PALHETA JR., R.C. et al. Atrial stretch delays gastric emptying of liquids in awake rats. Life sciences, Elmsford, NY, v. 92, n. 10, p. 569-575, mar. 2013. 0024-3205 |
url |
http://www.repositorio.ufc.br/handle/riufc/5688 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Life Sciences |
publisher.none.fl_str_mv |
Life Sciences |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813029028411473920 |