Atrial stretch delays gastric emptying of liquids in awake rats

Detalhes bibliográficos
Autor(a) principal: Palheta Júnior, Raimundo Campos
Data de Publicação: 2013
Outros Autores: Silva, Moisés Tolentino Bento da, Barbosa, H. L. G., Pinheiro, Ana Débora Nunes, Cardoso, KKátia Virgínia Viana, Graça, José Ronaldo Vasconcelos da, Magalhães, Pedro Jorge Caldas, Oliveira, Ricardo Brandt de, Santos, Armênio Aguiar dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5688
Resumo: Aims: We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Main methods: Anesthetizedmale rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day,mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20 min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70 μl saline for 5 min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30 min later. Key findings: Heart rate and CVP valueswere transiently increased by 50 or 70 μl AS but not 30 μl AS, whereas gastric emptying was slower after 30, 50, or 70 μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it. Significance: Atrial stretch inhibited the gastric emptying.
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spelling Atrial stretch delays gastric emptying of liquids in awake ratsÓxido NítricoRatosAims: We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Main methods: Anesthetizedmale rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day,mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20 min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70 μl saline for 5 min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30 min later. Key findings: Heart rate and CVP valueswere transiently increased by 50 or 70 μl AS but not 30 μl AS, whereas gastric emptying was slower after 30, 50, or 70 μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it. Significance: Atrial stretch inhibited the gastric emptying.Life Sciences2013-08-26T15:24:28Z2013-08-26T15:24:28Z2013-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPALHETA JR., R.C. et al. Atrial stretch delays gastric emptying of liquids in awake rats. Life sciences, Elmsford, NY, v. 92, n. 10, p. 569-575, mar. 2013.0024-3205http://www.repositorio.ufc.br/handle/riufc/5688Palheta Júnior, Raimundo CamposSilva, Moisés Tolentino Bento daBarbosa, H. L. G.Pinheiro, Ana Débora NunesCardoso, KKátia Virgínia VianaGraça, José Ronaldo Vasconcelos daMagalhães, Pedro Jorge CaldasOliveira, Ricardo Brandt deSantos, Armênio Aguiar dosengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-05-04T18:14:20Zoai:repositorio.ufc.br:riufc/5688Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T19:00:02.830368Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Atrial stretch delays gastric emptying of liquids in awake rats
title Atrial stretch delays gastric emptying of liquids in awake rats
spellingShingle Atrial stretch delays gastric emptying of liquids in awake rats
Palheta Júnior, Raimundo Campos
Óxido Nítrico
Ratos
title_short Atrial stretch delays gastric emptying of liquids in awake rats
title_full Atrial stretch delays gastric emptying of liquids in awake rats
title_fullStr Atrial stretch delays gastric emptying of liquids in awake rats
title_full_unstemmed Atrial stretch delays gastric emptying of liquids in awake rats
title_sort Atrial stretch delays gastric emptying of liquids in awake rats
author Palheta Júnior, Raimundo Campos
author_facet Palheta Júnior, Raimundo Campos
Silva, Moisés Tolentino Bento da
Barbosa, H. L. G.
Pinheiro, Ana Débora Nunes
Cardoso, KKátia Virgínia Viana
Graça, José Ronaldo Vasconcelos da
Magalhães, Pedro Jorge Caldas
Oliveira, Ricardo Brandt de
Santos, Armênio Aguiar dos
author_role author
author2 Silva, Moisés Tolentino Bento da
Barbosa, H. L. G.
Pinheiro, Ana Débora Nunes
Cardoso, KKátia Virgínia Viana
Graça, José Ronaldo Vasconcelos da
Magalhães, Pedro Jorge Caldas
Oliveira, Ricardo Brandt de
Santos, Armênio Aguiar dos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Palheta Júnior, Raimundo Campos
Silva, Moisés Tolentino Bento da
Barbosa, H. L. G.
Pinheiro, Ana Débora Nunes
Cardoso, KKátia Virgínia Viana
Graça, José Ronaldo Vasconcelos da
Magalhães, Pedro Jorge Caldas
Oliveira, Ricardo Brandt de
Santos, Armênio Aguiar dos
dc.subject.por.fl_str_mv Óxido Nítrico
Ratos
topic Óxido Nítrico
Ratos
description Aims: We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms. Main methods: Anesthetizedmale rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day,mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20 min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70 μl saline for 5 min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30 min later. Key findings: Heart rate and CVP valueswere transiently increased by 50 or 70 μl AS but not 30 μl AS, whereas gastric emptying was slower after 30, 50, or 70 μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy+celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it. Significance: Atrial stretch inhibited the gastric emptying.
publishDate 2013
dc.date.none.fl_str_mv 2013-08-26T15:24:28Z
2013-08-26T15:24:28Z
2013-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv PALHETA JR., R.C. et al. Atrial stretch delays gastric emptying of liquids in awake rats. Life sciences, Elmsford, NY, v. 92, n. 10, p. 569-575, mar. 2013.
0024-3205
http://www.repositorio.ufc.br/handle/riufc/5688
identifier_str_mv PALHETA JR., R.C. et al. Atrial stretch delays gastric emptying of liquids in awake rats. Life sciences, Elmsford, NY, v. 92, n. 10, p. 569-575, mar. 2013.
0024-3205
url http://www.repositorio.ufc.br/handle/riufc/5688
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Life Sciences
publisher.none.fl_str_mv Life Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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