In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds

Detalhes bibliográficos
Autor(a) principal: Oliveira, Maria Liduína Maia de
Data de Publicação: 2010
Outros Autores: Pinheiro, Diana Célia Sousa Nunes, Tomé, Adriana Rocha, Mota, Erika Freitas, Verde, Islene Araújo Lima, Pinheiro, Francisco Geraldo de Melo, Campello, Claudio Cabral, Morais, Selene Maia de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/63118
Resumo: Ethnopharmacological relevance: Caryocar coriaceumWittm. (Caryocaraceae), popularly known as pequi,is important source of food and used in the folk medicine as wound healing, anti-inflammatory and forthe treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer.Aim of the study:To evaluate the effects of fixed oil ofCaryocar coriaceum(FOCC) on the topical inflam-mation and cutaneous wound healing.Materials and methods:FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% onmodel of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excisionmodel in mice. Skin lesions were evaluated by planimetry and histological analysis.Results:FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%)inhibited the ear edema in 38.01% and 39.20% at time 15min and 1h, respectively, after induction ofinflammation, when compared to the positive control. The topical administration of FOCC ointment 12%showed a significantly reduction of unhealed wound area, with increased percentage of wound con-traction (96.54%) on day 7 when compared to the other groups. The results of histological evaluationsupported the outcome of excision wound model
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spelling In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seedsCaryocar coriaceumCaryocaraceaePequiFatty acidsWound healingTopical inflammationEthnopharmacological relevance: Caryocar coriaceumWittm. (Caryocaraceae), popularly known as pequi,is important source of food and used in the folk medicine as wound healing, anti-inflammatory and forthe treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer.Aim of the study:To evaluate the effects of fixed oil ofCaryocar coriaceum(FOCC) on the topical inflam-mation and cutaneous wound healing.Materials and methods:FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% onmodel of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excisionmodel in mice. Skin lesions were evaluated by planimetry and histological analysis.Results:FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%)inhibited the ear edema in 38.01% and 39.20% at time 15min and 1h, respectively, after induction ofinflammation, when compared to the positive control. The topical administration of FOCC ointment 12%showed a significantly reduction of unhealed wound area, with increased percentage of wound con-traction (96.54%) on day 7 when compared to the other groups. The results of histological evaluationsupported the outcome of excision wound modelJournal of Ethnopharmacology2021-12-20T13:43:08Z2021-12-20T13:43:08Z2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfOLIVEIRA, Maria Liduína Maia de et al. In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceumWittm. seeds. Journal of Ethnopharmacology, [s. l.], v. 129, p. 214-219, 2010.http://www.repositorio.ufc.br/handle/riufc/63118Oliveira, Maria Liduína Maia dePinheiro, Diana Célia Sousa NunesTomé, Adriana RochaMota, Erika FreitasVerde, Islene Araújo LimaPinheiro, Francisco Geraldo de MeloCampello, Claudio CabralMorais, Selene Maia deinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFC2023-10-10T19:40:22Zoai:repositorio.ufc.br:riufc/63118Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:53:06.198148Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
title In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
spellingShingle In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
Oliveira, Maria Liduína Maia de
Caryocar coriaceum
Caryocaraceae
Pequi
Fatty acids
Wound healing
Topical inflammation
title_short In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
title_full In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
title_fullStr In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
title_full_unstemmed In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
title_sort In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
author Oliveira, Maria Liduína Maia de
author_facet Oliveira, Maria Liduína Maia de
Pinheiro, Diana Célia Sousa Nunes
Tomé, Adriana Rocha
Mota, Erika Freitas
Verde, Islene Araújo Lima
Pinheiro, Francisco Geraldo de Melo
Campello, Claudio Cabral
Morais, Selene Maia de
author_role author
author2 Pinheiro, Diana Célia Sousa Nunes
Tomé, Adriana Rocha
Mota, Erika Freitas
Verde, Islene Araújo Lima
Pinheiro, Francisco Geraldo de Melo
Campello, Claudio Cabral
Morais, Selene Maia de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Maria Liduína Maia de
Pinheiro, Diana Célia Sousa Nunes
Tomé, Adriana Rocha
Mota, Erika Freitas
Verde, Islene Araújo Lima
Pinheiro, Francisco Geraldo de Melo
Campello, Claudio Cabral
Morais, Selene Maia de
dc.subject.por.fl_str_mv Caryocar coriaceum
Caryocaraceae
Pequi
Fatty acids
Wound healing
Topical inflammation
topic Caryocar coriaceum
Caryocaraceae
Pequi
Fatty acids
Wound healing
Topical inflammation
description Ethnopharmacological relevance: Caryocar coriaceumWittm. (Caryocaraceae), popularly known as pequi,is important source of food and used in the folk medicine as wound healing, anti-inflammatory and forthe treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer.Aim of the study:To evaluate the effects of fixed oil ofCaryocar coriaceum(FOCC) on the topical inflam-mation and cutaneous wound healing.Materials and methods:FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% onmodel of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excisionmodel in mice. Skin lesions were evaluated by planimetry and histological analysis.Results:FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%)inhibited the ear edema in 38.01% and 39.20% at time 15min and 1h, respectively, after induction ofinflammation, when compared to the positive control. The topical administration of FOCC ointment 12%showed a significantly reduction of unhealed wound area, with increased percentage of wound con-traction (96.54%) on day 7 when compared to the other groups. The results of histological evaluationsupported the outcome of excision wound model
publishDate 2010
dc.date.none.fl_str_mv 2010
2021-12-20T13:43:08Z
2021-12-20T13:43:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv OLIVEIRA, Maria Liduína Maia de et al. In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceumWittm. seeds. Journal of Ethnopharmacology, [s. l.], v. 129, p. 214-219, 2010.
http://www.repositorio.ufc.br/handle/riufc/63118
identifier_str_mv OLIVEIRA, Maria Liduína Maia de et al. In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceumWittm. seeds. Journal of Ethnopharmacology, [s. l.], v. 129, p. 214-219, 2010.
url http://www.repositorio.ufc.br/handle/riufc/63118
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Ethnopharmacology
publisher.none.fl_str_mv Journal of Ethnopharmacology
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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