In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/63118 |
Resumo: | Ethnopharmacological relevance: Caryocar coriaceumWittm. (Caryocaraceae), popularly known as pequi,is important source of food and used in the folk medicine as wound healing, anti-inflammatory and forthe treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer.Aim of the study:To evaluate the effects of fixed oil ofCaryocar coriaceum(FOCC) on the topical inflam-mation and cutaneous wound healing.Materials and methods:FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% onmodel of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excisionmodel in mice. Skin lesions were evaluated by planimetry and histological analysis.Results:FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%)inhibited the ear edema in 38.01% and 39.20% at time 15min and 1h, respectively, after induction ofinflammation, when compared to the positive control. The topical administration of FOCC ointment 12%showed a significantly reduction of unhealed wound area, with increased percentage of wound con-traction (96.54%) on day 7 when compared to the other groups. The results of histological evaluationsupported the outcome of excision wound model |
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In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seedsCaryocar coriaceumCaryocaraceaePequiFatty acidsWound healingTopical inflammationEthnopharmacological relevance: Caryocar coriaceumWittm. (Caryocaraceae), popularly known as pequi,is important source of food and used in the folk medicine as wound healing, anti-inflammatory and forthe treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer.Aim of the study:To evaluate the effects of fixed oil ofCaryocar coriaceum(FOCC) on the topical inflam-mation and cutaneous wound healing.Materials and methods:FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% onmodel of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excisionmodel in mice. Skin lesions were evaluated by planimetry and histological analysis.Results:FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%)inhibited the ear edema in 38.01% and 39.20% at time 15min and 1h, respectively, after induction ofinflammation, when compared to the positive control. The topical administration of FOCC ointment 12%showed a significantly reduction of unhealed wound area, with increased percentage of wound con-traction (96.54%) on day 7 when compared to the other groups. The results of histological evaluationsupported the outcome of excision wound modelJournal of Ethnopharmacology2021-12-20T13:43:08Z2021-12-20T13:43:08Z2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfOLIVEIRA, Maria Liduína Maia de et al. In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceumWittm. seeds. Journal of Ethnopharmacology, [s. l.], v. 129, p. 214-219, 2010.http://www.repositorio.ufc.br/handle/riufc/63118Oliveira, Maria Liduína Maia dePinheiro, Diana Célia Sousa NunesTomé, Adriana RochaMota, Erika FreitasVerde, Islene Araújo LimaPinheiro, Francisco Geraldo de MeloCampello, Claudio CabralMorais, Selene Maia deinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFC2023-10-10T19:40:22Zoai:repositorio.ufc.br:riufc/63118Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:53:06.198148Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds |
title |
In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds |
spellingShingle |
In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds Oliveira, Maria Liduína Maia de Caryocar coriaceum Caryocaraceae Pequi Fatty acids Wound healing Topical inflammation |
title_short |
In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds |
title_full |
In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds |
title_fullStr |
In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds |
title_full_unstemmed |
In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds |
title_sort |
In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds |
author |
Oliveira, Maria Liduína Maia de |
author_facet |
Oliveira, Maria Liduína Maia de Pinheiro, Diana Célia Sousa Nunes Tomé, Adriana Rocha Mota, Erika Freitas Verde, Islene Araújo Lima Pinheiro, Francisco Geraldo de Melo Campello, Claudio Cabral Morais, Selene Maia de |
author_role |
author |
author2 |
Pinheiro, Diana Célia Sousa Nunes Tomé, Adriana Rocha Mota, Erika Freitas Verde, Islene Araújo Lima Pinheiro, Francisco Geraldo de Melo Campello, Claudio Cabral Morais, Selene Maia de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Maria Liduína Maia de Pinheiro, Diana Célia Sousa Nunes Tomé, Adriana Rocha Mota, Erika Freitas Verde, Islene Araújo Lima Pinheiro, Francisco Geraldo de Melo Campello, Claudio Cabral Morais, Selene Maia de |
dc.subject.por.fl_str_mv |
Caryocar coriaceum Caryocaraceae Pequi Fatty acids Wound healing Topical inflammation |
topic |
Caryocar coriaceum Caryocaraceae Pequi Fatty acids Wound healing Topical inflammation |
description |
Ethnopharmacological relevance: Caryocar coriaceumWittm. (Caryocaraceae), popularly known as pequi,is important source of food and used in the folk medicine as wound healing, anti-inflammatory and forthe treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer.Aim of the study:To evaluate the effects of fixed oil ofCaryocar coriaceum(FOCC) on the topical inflam-mation and cutaneous wound healing.Materials and methods:FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% onmodel of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excisionmodel in mice. Skin lesions were evaluated by planimetry and histological analysis.Results:FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%)inhibited the ear edema in 38.01% and 39.20% at time 15min and 1h, respectively, after induction ofinflammation, when compared to the positive control. The topical administration of FOCC ointment 12%showed a significantly reduction of unhealed wound area, with increased percentage of wound con-traction (96.54%) on day 7 when compared to the other groups. The results of histological evaluationsupported the outcome of excision wound model |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2021-12-20T13:43:08Z 2021-12-20T13:43:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
OLIVEIRA, Maria Liduína Maia de et al. In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceumWittm. seeds. Journal of Ethnopharmacology, [s. l.], v. 129, p. 214-219, 2010. http://www.repositorio.ufc.br/handle/riufc/63118 |
identifier_str_mv |
OLIVEIRA, Maria Liduína Maia de et al. In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceumWittm. seeds. Journal of Ethnopharmacology, [s. l.], v. 129, p. 214-219, 2010. |
url |
http://www.repositorio.ufc.br/handle/riufc/63118 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Journal of Ethnopharmacology |
publisher.none.fl_str_mv |
Journal of Ethnopharmacology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028983746330624 |