Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
| Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/5253 |
Resumo: | This study aimed to evaluate the in vitro combination of farnesol and -lactams against Burkholderia pseudomallei . A total of 12 -lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 M. The combination of this compound with -lactams resulted in statistically significant -lactam MIC reduc- tion ( P < 0.05). This study provides new perspectives for the use of farnesol combined with -lactam antibiotics against strains of B. pseudomallei. |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomalleibeta-LactamasBurkholderiaThis study aimed to evaluate the in vitro combination of farnesol and -lactams against Burkholderia pseudomallei . A total of 12 -lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 M. The combination of this compound with -lactams resulted in statistically significant -lactam MIC reduc- tion ( P < 0.05). This study provides new perspectives for the use of farnesol combined with -lactam antibiotics against strains of B. pseudomallei.Antimicrobial Agents and Chemotherapy2013-07-05T12:12:30Z2013-07-05T12:12:30Z2012-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBRILHANTE, R. S. N. et al. Sesquiterpene farnesol contributes to increased susceptibility to beta-Lactams in strains of Burkholderia pseudomallei. Antimicrobial Agents and Chemotherapy, v. 56, n. 4, p. 2198-2200, abr. 2012.0066-4804http://www.repositorio.ufc.br/handle/riufc/5253Brilhante, Raimunda Sâmia NogueiraValente, L. G. A.Rocha, Marcos Fábio GadelhaBandeira, Tereza de Jesus Pinheiro GomesCordeiro, Rossana de AguiarLima, Rita Amanda Chaves deLeite, João Jaime GiffoniRibeiro, Joyce FontelesCastelo-Branco, Débora de Souza Collares MaiaMonteiro, Andre JallesSidrim, José Júlio CostaPereira, J. F.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-21T11:12:45Zoai:repositorio.ufc.br:riufc/5253Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:21:35.529276Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
| dc.title.none.fl_str_mv |
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei |
| title |
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei |
| spellingShingle |
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei Brilhante, Raimunda Sâmia Nogueira beta-Lactamas Burkholderia |
| title_short |
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei |
| title_full |
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei |
| title_fullStr |
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei |
| title_full_unstemmed |
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei |
| title_sort |
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei |
| author |
Brilhante, Raimunda Sâmia Nogueira |
| author_facet |
Brilhante, Raimunda Sâmia Nogueira Valente, L. G. A. Rocha, Marcos Fábio Gadelha Bandeira, Tereza de Jesus Pinheiro Gomes Cordeiro, Rossana de Aguiar Lima, Rita Amanda Chaves de Leite, João Jaime Giffoni Ribeiro, Joyce Fonteles Castelo-Branco, Débora de Souza Collares Maia Monteiro, Andre Jalles Sidrim, José Júlio Costa Pereira, J. F. |
| author_role |
author |
| author2 |
Valente, L. G. A. Rocha, Marcos Fábio Gadelha Bandeira, Tereza de Jesus Pinheiro Gomes Cordeiro, Rossana de Aguiar Lima, Rita Amanda Chaves de Leite, João Jaime Giffoni Ribeiro, Joyce Fonteles Castelo-Branco, Débora de Souza Collares Maia Monteiro, Andre Jalles Sidrim, José Júlio Costa Pereira, J. F. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Brilhante, Raimunda Sâmia Nogueira Valente, L. G. A. Rocha, Marcos Fábio Gadelha Bandeira, Tereza de Jesus Pinheiro Gomes Cordeiro, Rossana de Aguiar Lima, Rita Amanda Chaves de Leite, João Jaime Giffoni Ribeiro, Joyce Fonteles Castelo-Branco, Débora de Souza Collares Maia Monteiro, Andre Jalles Sidrim, José Júlio Costa Pereira, J. F. |
| dc.subject.por.fl_str_mv |
beta-Lactamas Burkholderia |
| topic |
beta-Lactamas Burkholderia |
| description |
This study aimed to evaluate the in vitro combination of farnesol and -lactams against Burkholderia pseudomallei . A total of 12 -lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 M. The combination of this compound with -lactams resulted in statistically significant -lactam MIC reduc- tion ( P < 0.05). This study provides new perspectives for the use of farnesol combined with -lactam antibiotics against strains of B. pseudomallei. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-04 2013-07-05T12:12:30Z 2013-07-05T12:12:30Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
BRILHANTE, R. S. N. et al. Sesquiterpene farnesol contributes to increased susceptibility to beta-Lactams in strains of Burkholderia pseudomallei. Antimicrobial Agents and Chemotherapy, v. 56, n. 4, p. 2198-2200, abr. 2012. 0066-4804 http://www.repositorio.ufc.br/handle/riufc/5253 |
| identifier_str_mv |
BRILHANTE, R. S. N. et al. Sesquiterpene farnesol contributes to increased susceptibility to beta-Lactams in strains of Burkholderia pseudomallei. Antimicrobial Agents and Chemotherapy, v. 56, n. 4, p. 2198-2200, abr. 2012. 0066-4804 |
| url |
http://www.repositorio.ufc.br/handle/riufc/5253 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Antimicrobial Agents and Chemotherapy |
| publisher.none.fl_str_mv |
Antimicrobial Agents and Chemotherapy |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
| instname_str |
Universidade Federal do Ceará (UFC) |
| instacron_str |
UFC |
| institution |
UFC |
| reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
| repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
| _version_ |
1813028770515255296 |