Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis

Detalhes bibliográficos
Autor(a) principal: Cavalcante, José Roosevelt
Data de Publicação: 2014
Outros Autores: Sampaio, João Paulo Aguiar, Maia Filho, João Tarcísio Alves, Vieira, Renato Braga, Eleutério Júnior, José, Lima Júnior, Roberto César Pereira, Almeida, Paulo Roberto Carvalho de, Ribeiro, Ronaldo Albuquerque
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
dARK ID: ark:/83112/001300000wz31
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/9523
Resumo: PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.
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network_name_str Repositório Institucional da Universidade Federal do Ceará (UFC)
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spelling Progressive loss of E-cadherin immunoexpression during cervical carcinogenesisCaderinasImuno-HistoquímicaNeoplasias do Colo do ÚteroPURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.Acta Cirúrgica Brasileira2014-10-21T15:46:12Z2014-10-21T15:46:12Z2014-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCAVALCANTE, J. R. et al. Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis1. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 10, p. 667-674, out., 2014.1618-2674 Onlinehttp://www.repositorio.ufc.br/handle/riufc/9523ark:/83112/001300000wz31Cavalcante, José RooseveltSampaio, João Paulo AguiarMaia Filho, João Tarcísio AlvesVieira, Renato BragaEleutério Júnior, JoséLima Júnior, Roberto César PereiraAlmeida, Paulo Roberto Carvalho deRibeiro, Ronaldo Albuquerqueengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2021-12-17T19:18:26Zoai:repositorio.ufc.br:riufc/9523Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:19:33.642454Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
title Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
spellingShingle Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
Cavalcante, José Roosevelt
Caderinas
Imuno-Histoquímica
Neoplasias do Colo do Útero
title_short Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
title_full Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
title_fullStr Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
title_full_unstemmed Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
title_sort Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
author Cavalcante, José Roosevelt
author_facet Cavalcante, José Roosevelt
Sampaio, João Paulo Aguiar
Maia Filho, João Tarcísio Alves
Vieira, Renato Braga
Eleutério Júnior, José
Lima Júnior, Roberto César Pereira
Almeida, Paulo Roberto Carvalho de
Ribeiro, Ronaldo Albuquerque
author_role author
author2 Sampaio, João Paulo Aguiar
Maia Filho, João Tarcísio Alves
Vieira, Renato Braga
Eleutério Júnior, José
Lima Júnior, Roberto César Pereira
Almeida, Paulo Roberto Carvalho de
Ribeiro, Ronaldo Albuquerque
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cavalcante, José Roosevelt
Sampaio, João Paulo Aguiar
Maia Filho, João Tarcísio Alves
Vieira, Renato Braga
Eleutério Júnior, José
Lima Júnior, Roberto César Pereira
Almeida, Paulo Roberto Carvalho de
Ribeiro, Ronaldo Albuquerque
dc.subject.por.fl_str_mv Caderinas
Imuno-Histoquímica
Neoplasias do Colo do Útero
topic Caderinas
Imuno-Histoquímica
Neoplasias do Colo do Útero
description PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-21T15:46:12Z
2014-10-21T15:46:12Z
2014-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv CAVALCANTE, J. R. et al. Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis1. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 10, p. 667-674, out., 2014.
1618-2674 Online
http://www.repositorio.ufc.br/handle/riufc/9523
dc.identifier.dark.fl_str_mv ark:/83112/001300000wz31
identifier_str_mv CAVALCANTE, J. R. et al. Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis1. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 10, p. 667-674, out., 2014.
1618-2674 Online
ark:/83112/001300000wz31
url http://www.repositorio.ufc.br/handle/riufc/9523
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Acta Cirúrgica Brasileira
publisher.none.fl_str_mv Acta Cirúrgica Brasileira
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1818373854825807872

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