Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission

Detalhes bibliográficos
Autor(a) principal: Magalhães, Herbert S.
Data de Publicação: 2020
Outros Autores: Silva, Alison B.da, Nascimento, Nilberto Robson Falcão do, Sousa, Luis Gustavo F. de, Fonseca, Maria Júlia S. da, Loiola, Maria Iracema B., Monteiro, Norberto K. V., Almeida Neto, Francisco Wagner de Queiroz, Canuto, Kirley Marques, Pessoa, Otilia Deusdênia L.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/64064
Resumo: The new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alka- loids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1, 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activity
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spelling Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmissionRauvolfia ligustrinaIndole alkaloidsNeuroinhibitory effectGIAO 13C NMRThe new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alka- loids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1, 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activityFitoterapia2022-02-18T18:32:46Z2022-02-18T18:32:46Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMAGALHÃES, Herbert S. et al. Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission. Fitoterapia, [s. l.], v. 143, p. 1-7, 2020.http://www.repositorio.ufc.br/handle/riufc/64064Magalhães, Herbert S.Silva, Alison B.daNascimento, Nilberto Robson Falcão doSousa, Luis Gustavo F. deFonseca, Maria Júlia S. daLoiola, Maria Iracema B.Monteiro, Norberto K. V.Almeida Neto, Francisco Wagner de QueirozCanuto, Kirley MarquesPessoa, Otilia Deusdênia L.info:eu-repo/semantics/openAccessporreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFC2023-10-10T19:32:18Zoai:repositorio.ufc.br:riufc/64064Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2023-10-10T19:32:18Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
title Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
spellingShingle Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
Magalhães, Herbert S.
Rauvolfia ligustrina
Indole alkaloids
Neuroinhibitory effect
GIAO 13C NMR
title_short Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
title_full Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
title_fullStr Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
title_full_unstemmed Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
title_sort Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
author Magalhães, Herbert S.
author_facet Magalhães, Herbert S.
Silva, Alison B.da
Nascimento, Nilberto Robson Falcão do
Sousa, Luis Gustavo F. de
Fonseca, Maria Júlia S. da
Loiola, Maria Iracema B.
Monteiro, Norberto K. V.
Almeida Neto, Francisco Wagner de Queiroz
Canuto, Kirley Marques
Pessoa, Otilia Deusdênia L.
author_role author
author2 Silva, Alison B.da
Nascimento, Nilberto Robson Falcão do
Sousa, Luis Gustavo F. de
Fonseca, Maria Júlia S. da
Loiola, Maria Iracema B.
Monteiro, Norberto K. V.
Almeida Neto, Francisco Wagner de Queiroz
Canuto, Kirley Marques
Pessoa, Otilia Deusdênia L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Magalhães, Herbert S.
Silva, Alison B.da
Nascimento, Nilberto Robson Falcão do
Sousa, Luis Gustavo F. de
Fonseca, Maria Júlia S. da
Loiola, Maria Iracema B.
Monteiro, Norberto K. V.
Almeida Neto, Francisco Wagner de Queiroz
Canuto, Kirley Marques
Pessoa, Otilia Deusdênia L.
dc.subject.por.fl_str_mv Rauvolfia ligustrina
Indole alkaloids
Neuroinhibitory effect
GIAO 13C NMR
topic Rauvolfia ligustrina
Indole alkaloids
Neuroinhibitory effect
GIAO 13C NMR
description The new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alka- loids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1, 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activity
publishDate 2020
dc.date.none.fl_str_mv 2020
2022-02-18T18:32:46Z
2022-02-18T18:32:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv MAGALHÃES, Herbert S. et al. Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission. Fitoterapia, [s. l.], v. 143, p. 1-7, 2020.
http://www.repositorio.ufc.br/handle/riufc/64064
identifier_str_mv MAGALHÃES, Herbert S. et al. Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission. Fitoterapia, [s. l.], v. 143, p. 1-7, 2020.
url http://www.repositorio.ufc.br/handle/riufc/64064
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Fitoterapia
publisher.none.fl_str_mv Fitoterapia
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1809935817975529472

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