Peripheral cytokine and chemokine alterations in depression : a meta-analysis of 82 studies

• Autor(a) principal: Köhler, Cristiano A.
• Data de Publicação: 2017
• Outros Autores: Freitas, Thiago H., Maes, Michael, Andrade, Nayanna Q. de, Liu, Celina S., Fernandes, Brisa S., Stubbs, Brendon, Solmi, M., Veronese, Nicola, Herrmann, Nathan, Raison, Charles L., Miller, Brian J., Lanctôt, Krista L., Carvalho, Andre F.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/23653
• topic: Depressão; Citocinas; Quimiocinas; Chemokines

Objective: To conduct a systematic revie w and meta -analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD ) compared to healthy controls (HCs). Method: The PubMed/MEDLINE, EMBASE, and PsycINFO databases were searched up until May 30, 2016. Effect sizes were estimated wi th random-effects mod els. Result: Eighty-two studies comprising 3212 participants with MDD and 2798 HCs met inclusion criteria. Peripheral levels of interleukin-6 (IL-6), tumor necrosi s factor (TNF)-alpha, IL-10, the solubl e IL-2 receptor, C-C chemokine ligand 2, IL-13, IL-18, IL-12, the IL-1 receptor antagonist, and the soluble TNF receptor 2 were elevated in patients with MDD compared to HCs, whereas interferon-gamma levels were lower in MDD (Hedge’s g = 0.477, P = 0.043). Levels of IL-1b, IL-2, IL-4, IL-8, the soluble IL-6 receptor (sIL-6R), IL-5, CCL- 3, IL-17, and transforming growth factor-beta 1 were not significantly altered in individuals with MDD compared to HCs. Hete rogeneity was large (I 2 : 51.6–97.7%), and sources of heterogeneity were explored (e.g., age, smoking status, and body mass index). Conclusion: Our results further charact erize a cytokine/chemokine profile associated with MDD. Future studies are warranted to further elucidate sources of heterog eneity, as well as biosignature cytokines secreted by other immune cells.