What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases

Detalhes bibliográficos
Autor(a) principal: Costa, Débora Menezes da
Data de Publicação: 2015
Outros Autores: Pereira, Eliane dos Santos, Barem Rabenhorst, Silvia Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/16831
Resumo: The Helicobacter pylori (H. pylori) infection is present in more than half the world’s population and it has been associated with several gastric disorders, as gastritis, peptic ulceration and gastric adenocarcinoma. The clinical outcome of this infection depends on host and bacterium factors where H. pylori virulence genes seem to play a relevant role. Until now, cagA and vacA genes were studied and established in the literature as determining factors in gastric pathogenesis. However, there are percentages of gastric cancer cases that are cagA-negative. Several other virulence genes have been searched but these genes still remain in the shadow of cagA and vacA. Thus, this review aimed to bring up which genes have been suggested as potentially relevant virulence factors for H. pylori associated gastrointestinal diseases. We focused on the cagpathogenicity island, genes with adherence and motility functions and iceA based on its relevance shown in several studies in the literature.
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spelling What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseasesHelicobacter pyloriMotilidade GastrointestinalThe Helicobacter pylori (H. pylori) infection is present in more than half the world’s population and it has been associated with several gastric disorders, as gastritis, peptic ulceration and gastric adenocarcinoma. The clinical outcome of this infection depends on host and bacterium factors where H. pylori virulence genes seem to play a relevant role. Until now, cagA and vacA genes were studied and established in the literature as determining factors in gastric pathogenesis. However, there are percentages of gastric cancer cases that are cagA-negative. Several other virulence genes have been searched but these genes still remain in the shadow of cagA and vacA. Thus, this review aimed to bring up which genes have been suggested as potentially relevant virulence factors for H. pylori associated gastrointestinal diseases. We focused on the cagpathogenicity island, genes with adherence and motility functions and iceA based on its relevance shown in several studies in the literature.World Journal of Gastroenterology2016-05-17T14:11:48Z2016-05-17T14:11:48Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCOSTA, D. M. ; PEREIRA, E. S. ; RABENHORST, S. H. B. What exists beyond cagA and vacA? genes in gastric diseases. World Journal of Gastroenterology, Beijing, v. 21, p. 1-32, 2015.1007-9327http://www.repositorio.ufc.br/handle/riufc/16831Costa, Débora Menezes daPereira, Eliane dos SantosBarem Rabenhorst, Silvia Helenaengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-21T14:19:02Zoai:repositorio.ufc.br:riufc/16831Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:53:52.453927Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
title What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
spellingShingle What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
Costa, Débora Menezes da
Helicobacter pylori
Motilidade Gastrointestinal
title_short What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
title_full What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
title_fullStr What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
title_full_unstemmed What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
title_sort What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
author Costa, Débora Menezes da
author_facet Costa, Débora Menezes da
Pereira, Eliane dos Santos
Barem Rabenhorst, Silvia Helena
author_role author
author2 Pereira, Eliane dos Santos
Barem Rabenhorst, Silvia Helena
author2_role author
author
dc.contributor.author.fl_str_mv Costa, Débora Menezes da
Pereira, Eliane dos Santos
Barem Rabenhorst, Silvia Helena
dc.subject.por.fl_str_mv Helicobacter pylori
Motilidade Gastrointestinal
topic Helicobacter pylori
Motilidade Gastrointestinal
description The Helicobacter pylori (H. pylori) infection is present in more than half the world’s population and it has been associated with several gastric disorders, as gastritis, peptic ulceration and gastric adenocarcinoma. The clinical outcome of this infection depends on host and bacterium factors where H. pylori virulence genes seem to play a relevant role. Until now, cagA and vacA genes were studied and established in the literature as determining factors in gastric pathogenesis. However, there are percentages of gastric cancer cases that are cagA-negative. Several other virulence genes have been searched but these genes still remain in the shadow of cagA and vacA. Thus, this review aimed to bring up which genes have been suggested as potentially relevant virulence factors for H. pylori associated gastrointestinal diseases. We focused on the cagpathogenicity island, genes with adherence and motility functions and iceA based on its relevance shown in several studies in the literature.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016-05-17T14:11:48Z
2016-05-17T14:11:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv COSTA, D. M. ; PEREIRA, E. S. ; RABENHORST, S. H. B. What exists beyond cagA and vacA? genes in gastric diseases. World Journal of Gastroenterology, Beijing, v. 21, p. 1-32, 2015.
1007-9327
http://www.repositorio.ufc.br/handle/riufc/16831
identifier_str_mv COSTA, D. M. ; PEREIRA, E. S. ; RABENHORST, S. H. B. What exists beyond cagA and vacA? genes in gastric diseases. World Journal of Gastroenterology, Beijing, v. 21, p. 1-32, 2015.
1007-9327
url http://www.repositorio.ufc.br/handle/riufc/16831
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv World Journal of Gastroenterology
publisher.none.fl_str_mv World Journal of Gastroenterology
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1813028988590751744

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