Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil

Detalhes bibliográficos
Autor(a) principal: Pereira, Eliane dos Santos
Data de Publicação: 2015
Outros Autores: Silva-Fernandes, Isabelle Joyce de Lima, Costa, Débora Menezes da, Burbano, Rommel Mario Rodriguez, Rabenhorst, Silvia Helena Barem
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/16829
Resumo: SNPs have been associated with gastric cancer susceptibility. Thus, we evaluated the influence of SNPs in DNA repair genes APE1 2197(T>G) and MLH1 -93(G>A), as well as in CDH1 at positions -160 (C>A) and -347 (G>GA) in gastric cancer risk. Analyses were performed on 264 GC patients and 391 healthy controls matched by age and sex from two regions in Brazil, Ceará and Pará. In the general analysis, a protective was found for the GGA of the CDH1-347 (G>GA). Considering the GC subtypes, the polymorphic allele of both CDH1 SNPs was associated with protection to intestinal subtype. In this subtype, the MLH1 (G>A) allele A was associated with risk, contrast with protection to diffuse subtype. In females, a risk was associated with AA genotype of MLH1 (G>A) and a protection with APE1 (T>G) and CDH1 -347 (G>GA) polymorphic alleles. Considering H. pylori , the APE1 (T>G) G allele was associated with low virulence strains, while MLH1 (G>A) GA genotype was associated with more virulence strains. The MLH1 (G>A) A allele in the intestinal subtype was associated with more virulence strains. Considering the two regions studied, we observed that the associations found regarding APE1 (T>G), MLH1 (G>A) and CDH1-347 (G>GA) polymorphic alleles, were only linked to patients from Pará State. Protection was associated with CA of the CDH1-160 (C>A) in males from Ceará State. In summary, our data show that these SNPs are potentials markers of susceptibility to the different subtypes of GC, in which gender is also an important aspect.
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spelling Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from BrazilNeoplasias GástricasHelicobacter pyloriSNPs have been associated with gastric cancer susceptibility. Thus, we evaluated the influence of SNPs in DNA repair genes APE1 2197(T>G) and MLH1 -93(G>A), as well as in CDH1 at positions -160 (C>A) and -347 (G>GA) in gastric cancer risk. Analyses were performed on 264 GC patients and 391 healthy controls matched by age and sex from two regions in Brazil, Ceará and Pará. In the general analysis, a protective was found for the GGA of the CDH1-347 (G>GA). Considering the GC subtypes, the polymorphic allele of both CDH1 SNPs was associated with protection to intestinal subtype. In this subtype, the MLH1 (G>A) allele A was associated with risk, contrast with protection to diffuse subtype. In females, a risk was associated with AA genotype of MLH1 (G>A) and a protection with APE1 (T>G) and CDH1 -347 (G>GA) polymorphic alleles. Considering H. pylori , the APE1 (T>G) G allele was associated with low virulence strains, while MLH1 (G>A) GA genotype was associated with more virulence strains. The MLH1 (G>A) A allele in the intestinal subtype was associated with more virulence strains. Considering the two regions studied, we observed that the associations found regarding APE1 (T>G), MLH1 (G>A) and CDH1-347 (G>GA) polymorphic alleles, were only linked to patients from Pará State. Protection was associated with CA of the CDH1-160 (C>A) in males from Ceará State. In summary, our data show that these SNPs are potentials markers of susceptibility to the different subtypes of GC, in which gender is also an important aspect.European Academic Research2016-05-17T12:36:00Z2016-05-17T12:36:00Z2015-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPEREIRA, E. S. et al. Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil. European Academic Research, v. 3, n. 1, p. 452-471, apr. 2015.2286-4822http://www.repositorio.ufc.br/handle/riufc/16829Pereira, Eliane dos SantosSilva-Fernandes, Isabelle Joyce de LimaCosta, Débora Menezes daBurbano, Rommel Mario RodriguezRabenhorst, Silvia Helena Baremengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-21T14:20:44Zoai:repositorio.ufc.br:riufc/16829Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:47:45.514808Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil
title Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil
spellingShingle Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil
Pereira, Eliane dos Santos
Neoplasias Gástricas
Helicobacter pylori
title_short Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil
title_full Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil
title_fullStr Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil
title_full_unstemmed Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil
title_sort Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil
author Pereira, Eliane dos Santos
author_facet Pereira, Eliane dos Santos
Silva-Fernandes, Isabelle Joyce de Lima
Costa, Débora Menezes da
Burbano, Rommel Mario Rodriguez
Rabenhorst, Silvia Helena Barem
author_role author
author2 Silva-Fernandes, Isabelle Joyce de Lima
Costa, Débora Menezes da
Burbano, Rommel Mario Rodriguez
Rabenhorst, Silvia Helena Barem
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Eliane dos Santos
Silva-Fernandes, Isabelle Joyce de Lima
Costa, Débora Menezes da
Burbano, Rommel Mario Rodriguez
Rabenhorst, Silvia Helena Barem
dc.subject.por.fl_str_mv Neoplasias Gástricas
Helicobacter pylori
topic Neoplasias Gástricas
Helicobacter pylori
description SNPs have been associated with gastric cancer susceptibility. Thus, we evaluated the influence of SNPs in DNA repair genes APE1 2197(T>G) and MLH1 -93(G>A), as well as in CDH1 at positions -160 (C>A) and -347 (G>GA) in gastric cancer risk. Analyses were performed on 264 GC patients and 391 healthy controls matched by age and sex from two regions in Brazil, Ceará and Pará. In the general analysis, a protective was found for the GGA of the CDH1-347 (G>GA). Considering the GC subtypes, the polymorphic allele of both CDH1 SNPs was associated with protection to intestinal subtype. In this subtype, the MLH1 (G>A) allele A was associated with risk, contrast with protection to diffuse subtype. In females, a risk was associated with AA genotype of MLH1 (G>A) and a protection with APE1 (T>G) and CDH1 -347 (G>GA) polymorphic alleles. Considering H. pylori , the APE1 (T>G) G allele was associated with low virulence strains, while MLH1 (G>A) GA genotype was associated with more virulence strains. The MLH1 (G>A) A allele in the intestinal subtype was associated with more virulence strains. Considering the two regions studied, we observed that the associations found regarding APE1 (T>G), MLH1 (G>A) and CDH1-347 (G>GA) polymorphic alleles, were only linked to patients from Pará State. Protection was associated with CA of the CDH1-160 (C>A) in males from Ceará State. In summary, our data show that these SNPs are potentials markers of susceptibility to the different subtypes of GC, in which gender is also an important aspect.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
2016-05-17T12:36:00Z
2016-05-17T12:36:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv PEREIRA, E. S. et al. Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil. European Academic Research, v. 3, n. 1, p. 452-471, apr. 2015.
2286-4822
http://www.repositorio.ufc.br/handle/riufc/16829
identifier_str_mv PEREIRA, E. S. et al. Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with gastric carcinoma risk in population from Brazil. European Academic Research, v. 3, n. 1, p. 452-471, apr. 2015.
2286-4822
url http://www.repositorio.ufc.br/handle/riufc/16829
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv European Academic Research
publisher.none.fl_str_mv European Academic Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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