Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi

Detalhes bibliográficos
Autor(a) principal: Silva-Pinto, Ana Cristina
Data de Publicação: 2014
Outros Autores: Ladeira, Simery de Oliveira Domingues, Brunetta, Denise Menezes, Santis, Gil Cunha De, Angulo, Ivan de Lucena, Covas, Dimas Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/22423
Resumo: Objective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complications in the newborn were analyzed. Results: A total of 26% of the cases reported previous miscarriages, 20% had preterm labor, 10% had pre-eclampsia, and 5% had gestational diabetes. Forty-one percent of the deliveries were cesarean sections and 29% of patients required blood transfusions. In respect to sickle cell disease, 62% of patients had vaso-occlusive crises, 29% had acute chest syndrome, 23% had urinary tract infection, 15% had impaired cardiac function and 6% developed pulmonary hypertension. Only one patient died in the postnatal period due to acute chest syndrome. The mean gestational age was 37.8 ± 2.63 weeks, and mean newborn weight was 2.809 ± 643.8 g. There were seven fetal losses, including three stillbirths and four miscarriages. The impact of transfusion therapy on the incidence of maternal–fetal complications during pregnancy was evaluated. Conclusions: Pregnancy in sickle cell patients is still associated with complications. Although no statistical difference was observed between transfused and non-transfused women, there were no deaths (fetal or maternal) in transfused patients whereas one maternal death and three stillbirths occurred in non-transfused women. A larger study of sickle cell pregnant women will be necessary to elucidate the actual role of transfusion during pregnancy in sickle cell disease.
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spelling Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, BraziAnemia FalciformeGravdidezAnemia, Sickle CellObjective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complications in the newborn were analyzed. Results: A total of 26% of the cases reported previous miscarriages, 20% had preterm labor, 10% had pre-eclampsia, and 5% had gestational diabetes. Forty-one percent of the deliveries were cesarean sections and 29% of patients required blood transfusions. In respect to sickle cell disease, 62% of patients had vaso-occlusive crises, 29% had acute chest syndrome, 23% had urinary tract infection, 15% had impaired cardiac function and 6% developed pulmonary hypertension. Only one patient died in the postnatal period due to acute chest syndrome. The mean gestational age was 37.8 ± 2.63 weeks, and mean newborn weight was 2.809 ± 643.8 g. There were seven fetal losses, including three stillbirths and four miscarriages. The impact of transfusion therapy on the incidence of maternal–fetal complications during pregnancy was evaluated. Conclusions: Pregnancy in sickle cell patients is still associated with complications. Although no statistical difference was observed between transfused and non-transfused women, there were no deaths (fetal or maternal) in transfused patients whereas one maternal death and three stillbirths occurred in non-transfused women. A larger study of sickle cell pregnant women will be necessary to elucidate the actual role of transfusion during pregnancy in sickle cell disease.Revista Brasileira de Hematologia e Hemoterapia2017-03-30T12:49:03Z2017-03-30T12:49:03Z2014-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSILVA-PINTO, A. C. et al. Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 36, n. 5, p. 329-333, 2014.1516-8484http://www.repositorio.ufc.br/handle/riufc/22423Silva-Pinto, Ana CristinaLadeira, Simery de Oliveira DominguesBrunetta, Denise MenezesSantis, Gil Cunha DeAngulo, Ivan de LucenaCovas, Dimas Tadeuengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2018-12-17T10:38:13Zoai:repositorio.ufc.br:riufc/22423Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:48:58.844806Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
title Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
spellingShingle Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
Silva-Pinto, Ana Cristina
Anemia Falciforme
Gravdidez
Anemia, Sickle Cell
title_short Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
title_full Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
title_fullStr Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
title_full_unstemmed Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
title_sort Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
author Silva-Pinto, Ana Cristina
author_facet Silva-Pinto, Ana Cristina
Ladeira, Simery de Oliveira Domingues
Brunetta, Denise Menezes
Santis, Gil Cunha De
Angulo, Ivan de Lucena
Covas, Dimas Tadeu
author_role author
author2 Ladeira, Simery de Oliveira Domingues
Brunetta, Denise Menezes
Santis, Gil Cunha De
Angulo, Ivan de Lucena
Covas, Dimas Tadeu
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva-Pinto, Ana Cristina
Ladeira, Simery de Oliveira Domingues
Brunetta, Denise Menezes
Santis, Gil Cunha De
Angulo, Ivan de Lucena
Covas, Dimas Tadeu
dc.subject.por.fl_str_mv Anemia Falciforme
Gravdidez
Anemia, Sickle Cell
topic Anemia Falciforme
Gravdidez
Anemia, Sickle Cell
description Objective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complications in the newborn were analyzed. Results: A total of 26% of the cases reported previous miscarriages, 20% had preterm labor, 10% had pre-eclampsia, and 5% had gestational diabetes. Forty-one percent of the deliveries were cesarean sections and 29% of patients required blood transfusions. In respect to sickle cell disease, 62% of patients had vaso-occlusive crises, 29% had acute chest syndrome, 23% had urinary tract infection, 15% had impaired cardiac function and 6% developed pulmonary hypertension. Only one patient died in the postnatal period due to acute chest syndrome. The mean gestational age was 37.8 ± 2.63 weeks, and mean newborn weight was 2.809 ± 643.8 g. There were seven fetal losses, including three stillbirths and four miscarriages. The impact of transfusion therapy on the incidence of maternal–fetal complications during pregnancy was evaluated. Conclusions: Pregnancy in sickle cell patients is still associated with complications. Although no statistical difference was observed between transfused and non-transfused women, there were no deaths (fetal or maternal) in transfused patients whereas one maternal death and three stillbirths occurred in non-transfused women. A larger study of sickle cell pregnant women will be necessary to elucidate the actual role of transfusion during pregnancy in sickle cell disease.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
2017-03-30T12:49:03Z
2017-03-30T12:49:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SILVA-PINTO, A. C. et al. Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 36, n. 5, p. 329-333, 2014.
1516-8484
http://www.repositorio.ufc.br/handle/riufc/22423
identifier_str_mv SILVA-PINTO, A. C. et al. Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 36, n. 5, p. 329-333, 2014.
1516-8484
url http://www.repositorio.ufc.br/handle/riufc/22423
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia
publisher.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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