Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/22423 |
Resumo: | Objective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complications in the newborn were analyzed. Results: A total of 26% of the cases reported previous miscarriages, 20% had preterm labor, 10% had pre-eclampsia, and 5% had gestational diabetes. Forty-one percent of the deliveries were cesarean sections and 29% of patients required blood transfusions. In respect to sickle cell disease, 62% of patients had vaso-occlusive crises, 29% had acute chest syndrome, 23% had urinary tract infection, 15% had impaired cardiac function and 6% developed pulmonary hypertension. Only one patient died in the postnatal period due to acute chest syndrome. The mean gestational age was 37.8 ± 2.63 weeks, and mean newborn weight was 2.809 ± 643.8 g. There were seven fetal losses, including three stillbirths and four miscarriages. The impact of transfusion therapy on the incidence of maternal–fetal complications during pregnancy was evaluated. Conclusions: Pregnancy in sickle cell patients is still associated with complications. Although no statistical difference was observed between transfused and non-transfused women, there were no deaths (fetal or maternal) in transfused patients whereas one maternal death and three stillbirths occurred in non-transfused women. A larger study of sickle cell pregnant women will be necessary to elucidate the actual role of transfusion during pregnancy in sickle cell disease. |
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Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, BraziAnemia FalciformeGravdidezAnemia, Sickle CellObjective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complications in the newborn were analyzed. Results: A total of 26% of the cases reported previous miscarriages, 20% had preterm labor, 10% had pre-eclampsia, and 5% had gestational diabetes. Forty-one percent of the deliveries were cesarean sections and 29% of patients required blood transfusions. In respect to sickle cell disease, 62% of patients had vaso-occlusive crises, 29% had acute chest syndrome, 23% had urinary tract infection, 15% had impaired cardiac function and 6% developed pulmonary hypertension. Only one patient died in the postnatal period due to acute chest syndrome. The mean gestational age was 37.8 ± 2.63 weeks, and mean newborn weight was 2.809 ± 643.8 g. There were seven fetal losses, including three stillbirths and four miscarriages. The impact of transfusion therapy on the incidence of maternal–fetal complications during pregnancy was evaluated. Conclusions: Pregnancy in sickle cell patients is still associated with complications. Although no statistical difference was observed between transfused and non-transfused women, there were no deaths (fetal or maternal) in transfused patients whereas one maternal death and three stillbirths occurred in non-transfused women. A larger study of sickle cell pregnant women will be necessary to elucidate the actual role of transfusion during pregnancy in sickle cell disease.Revista Brasileira de Hematologia e Hemoterapia2017-03-30T12:49:03Z2017-03-30T12:49:03Z2014-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSILVA-PINTO, A. C. et al. Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 36, n. 5, p. 329-333, 2014.1516-8484http://www.repositorio.ufc.br/handle/riufc/22423Silva-Pinto, Ana CristinaLadeira, Simery de Oliveira DominguesBrunetta, Denise MenezesSantis, Gil Cunha DeAngulo, Ivan de LucenaCovas, Dimas Tadeuengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2018-12-17T10:38:13Zoai:repositorio.ufc.br:riufc/22423Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:48:58.844806Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi |
title |
Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi |
spellingShingle |
Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi Silva-Pinto, Ana Cristina Anemia Falciforme Gravdidez Anemia, Sickle Cell |
title_short |
Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi |
title_full |
Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi |
title_fullStr |
Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi |
title_full_unstemmed |
Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi |
title_sort |
Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi |
author |
Silva-Pinto, Ana Cristina |
author_facet |
Silva-Pinto, Ana Cristina Ladeira, Simery de Oliveira Domingues Brunetta, Denise Menezes Santis, Gil Cunha De Angulo, Ivan de Lucena Covas, Dimas Tadeu |
author_role |
author |
author2 |
Ladeira, Simery de Oliveira Domingues Brunetta, Denise Menezes Santis, Gil Cunha De Angulo, Ivan de Lucena Covas, Dimas Tadeu |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva-Pinto, Ana Cristina Ladeira, Simery de Oliveira Domingues Brunetta, Denise Menezes Santis, Gil Cunha De Angulo, Ivan de Lucena Covas, Dimas Tadeu |
dc.subject.por.fl_str_mv |
Anemia Falciforme Gravdidez Anemia, Sickle Cell |
topic |
Anemia Falciforme Gravdidez Anemia, Sickle Cell |
description |
Objective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complications in the newborn were analyzed. Results: A total of 26% of the cases reported previous miscarriages, 20% had preterm labor, 10% had pre-eclampsia, and 5% had gestational diabetes. Forty-one percent of the deliveries were cesarean sections and 29% of patients required blood transfusions. In respect to sickle cell disease, 62% of patients had vaso-occlusive crises, 29% had acute chest syndrome, 23% had urinary tract infection, 15% had impaired cardiac function and 6% developed pulmonary hypertension. Only one patient died in the postnatal period due to acute chest syndrome. The mean gestational age was 37.8 ± 2.63 weeks, and mean newborn weight was 2.809 ± 643.8 g. There were seven fetal losses, including three stillbirths and four miscarriages. The impact of transfusion therapy on the incidence of maternal–fetal complications during pregnancy was evaluated. Conclusions: Pregnancy in sickle cell patients is still associated with complications. Although no statistical difference was observed between transfused and non-transfused women, there were no deaths (fetal or maternal) in transfused patients whereas one maternal death and three stillbirths occurred in non-transfused women. A larger study of sickle cell pregnant women will be necessary to elucidate the actual role of transfusion during pregnancy in sickle cell disease. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09 2017-03-30T12:49:03Z 2017-03-30T12:49:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SILVA-PINTO, A. C. et al. Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 36, n. 5, p. 329-333, 2014. 1516-8484 http://www.repositorio.ufc.br/handle/riufc/22423 |
identifier_str_mv |
SILVA-PINTO, A. C. et al. Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 36, n. 5, p. 329-333, 2014. 1516-8484 |
url |
http://www.repositorio.ufc.br/handle/riufc/22423 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia |
publisher.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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1813028957541367808 |