In vitro effect of Sulfamethoxazole-Trimethoprim against Histoplasma capsulatum var. capsulatum

• Autor(a) principal: Brilhante, Raimunda Sâmia Nogueira
• Data de Publicação: 2010
• Outros Autores: Fechine, Maria Auxiliadora Bezerra, Cordeiro, Rossana de Aguiar, Rocha, Marcos Fa ́bio Gadelha, Ribeiro, Joyce Fonteles, Monteiro, André Jalles, Lima, Rita Amanda Chaves de, Mesquita, Jaco ́ Ricarte Lima, Camargo, Zoilo Pires de, Sidrim, Jóse Júlio Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5280
• topic: Histoplasma; HIV

This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/ 0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.