In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life

Detalhes bibliográficos
Autor(a) principal: Moraes, Juliana Brum
Data de Publicação: 2018
Outros Autores: Maes, Michael, Roomruangwong, Chutima, Bonifacio, Kamila Landucci, Barbosa, Decio Sabbatini, Vargas, Heber Odebrecht, Anderson, George, Kubera, Marta, Carvalho, Andre F., Nunes, Sandra Odebrecht Vargas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/32418
Resumo: Early life trauma (ELT) may increase the risk towards bipolar diso rder (BD) and major depression (MDD), disorders associated with activated neuro-oxidative and neuro-nitrosative stress (O&NS) p athways. It has remained elusive whether ELTs are associated with O&NS and which ELTs are associated with disti nct affective disorder phenotypes. This case-control study examined patients with BD ( n = 68) and MDD ( n = 37) and healthy controls ( n = 66). The Child Trauma Questionnaire (CTQ) was used to assess specific ELT. We measured malondialdehyde (MDA) , lipid hydroperoxides (LOOH), superoxide dismutase (SOD), catalase, advanced oxidation protein products (AOPP); NO metabolites (NOx), paraoxonase 1 activity, zinc, albumin, high density lipoprotein cho- lesterol and -SH groups and computed z-unit weighted composite scores. Physical neglect significantly predicts higher z-unit weighted composite scores of LOOH+SOD, LOOH+SOD+NOx, LOOH+SOD+NOx + MDA and LOOH+SOD+NOx + AOPP. Sexual abuse was associated with a significantly lower composite s core of zinc+albumin+SH. Emotio nal abuse was associated with severity of depression and anxiety, number of depressive and mani c episodes, alcohol and hypnotics use, lifetime suicidal behavior and lowered quality of life. Sexual abuse was associated with an increased risk towards BD, but not MDD. ELT, especially physical neglect, may drive increased (nitro-)oxidativ e stress coupled with lipid and protein oxida tion, which - together with emotional abuse - may play a role in severity of illness, lowered quality of life and MDD. ELTs are also associated with the onset of BD, but this link did not appear to be related to activated O&NS pathways. These novel findings deserve confirma tion in prospective studies.
id UFC-7_f5ff9859f10fc1710cdee3a759cfcc1d
oai_identifier_str oai:repositorio.ufc.br:riufc/32418
network_acronym_str UFC-7
network_name_str Repositório Institucional da Universidade Federal do Ceará (UFC)
repository_id_str
spelling In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of lifeTranstorno BipolarBipolar DisorderEstresse OxidativoOxidative StressEarly life trauma (ELT) may increase the risk towards bipolar diso rder (BD) and major depression (MDD), disorders associated with activated neuro-oxidative and neuro-nitrosative stress (O&NS) p athways. It has remained elusive whether ELTs are associated with O&NS and which ELTs are associated with disti nct affective disorder phenotypes. This case-control study examined patients with BD ( n = 68) and MDD ( n = 37) and healthy controls ( n = 66). The Child Trauma Questionnaire (CTQ) was used to assess specific ELT. We measured malondialdehyde (MDA) , lipid hydroperoxides (LOOH), superoxide dismutase (SOD), catalase, advanced oxidation protein products (AOPP); NO metabolites (NOx), paraoxonase 1 activity, zinc, albumin, high density lipoprotein cho- lesterol and -SH groups and computed z-unit weighted composite scores. Physical neglect significantly predicts higher z-unit weighted composite scores of LOOH+SOD, LOOH+SOD+NOx, LOOH+SOD+NOx + MDA and LOOH+SOD+NOx + AOPP. Sexual abuse was associated with a significantly lower composite s core of zinc+albumin+SH. Emotio nal abuse was associated with severity of depression and anxiety, number of depressive and mani c episodes, alcohol and hypnotics use, lifetime suicidal behavior and lowered quality of life. Sexual abuse was associated with an increased risk towards BD, but not MDD. ELT, especially physical neglect, may drive increased (nitro-)oxidativ e stress coupled with lipid and protein oxida tion, which - together with emotional abuse - may play a role in severity of illness, lowered quality of life and MDD. ELTs are also associated with the onset of BD, but this link did not appear to be related to activated O&NS pathways. These novel findings deserve confirma tion in prospective studies.Metabolic Brain Disease2018-05-30T14:06:09Z2018-05-30T14:06:09Z2018-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMORAES, J. B. et al. In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life. Metabolic Brain Disease, New York, p. 1-16, mar. 2018.0885-74901573-7365 (On-line)http://www.repositorio.ufc.br/handle/riufc/32418Moraes, Juliana BrumMaes, MichaelRoomruangwong, ChutimaBonifacio, Kamila LanducciBarbosa, Decio SabbatiniVargas, Heber OdebrechtAnderson, GeorgeKubera, MartaCarvalho, Andre F.Nunes, Sandra Odebrecht Vargasengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2021-03-29T17:40:05Zoai:repositorio.ufc.br:riufc/32418Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T19:02:57.126014Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
title In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
spellingShingle In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
Moraes, Juliana Brum
Transtorno Bipolar
Bipolar Disorder
Estresse Oxidativo
Oxidative Stress
title_short In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
title_full In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
title_fullStr In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
title_full_unstemmed In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
title_sort In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life
author Moraes, Juliana Brum
author_facet Moraes, Juliana Brum
Maes, Michael
Roomruangwong, Chutima
Bonifacio, Kamila Landucci
Barbosa, Decio Sabbatini
Vargas, Heber Odebrecht
Anderson, George
Kubera, Marta
Carvalho, Andre F.
Nunes, Sandra Odebrecht Vargas
author_role author
author2 Maes, Michael
Roomruangwong, Chutima
Bonifacio, Kamila Landucci
Barbosa, Decio Sabbatini
Vargas, Heber Odebrecht
Anderson, George
Kubera, Marta
Carvalho, Andre F.
Nunes, Sandra Odebrecht Vargas
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moraes, Juliana Brum
Maes, Michael
Roomruangwong, Chutima
Bonifacio, Kamila Landucci
Barbosa, Decio Sabbatini
Vargas, Heber Odebrecht
Anderson, George
Kubera, Marta
Carvalho, Andre F.
Nunes, Sandra Odebrecht Vargas
dc.subject.por.fl_str_mv Transtorno Bipolar
Bipolar Disorder
Estresse Oxidativo
Oxidative Stress
topic Transtorno Bipolar
Bipolar Disorder
Estresse Oxidativo
Oxidative Stress
description Early life trauma (ELT) may increase the risk towards bipolar diso rder (BD) and major depression (MDD), disorders associated with activated neuro-oxidative and neuro-nitrosative stress (O&NS) p athways. It has remained elusive whether ELTs are associated with O&NS and which ELTs are associated with disti nct affective disorder phenotypes. This case-control study examined patients with BD ( n = 68) and MDD ( n = 37) and healthy controls ( n = 66). The Child Trauma Questionnaire (CTQ) was used to assess specific ELT. We measured malondialdehyde (MDA) , lipid hydroperoxides (LOOH), superoxide dismutase (SOD), catalase, advanced oxidation protein products (AOPP); NO metabolites (NOx), paraoxonase 1 activity, zinc, albumin, high density lipoprotein cho- lesterol and -SH groups and computed z-unit weighted composite scores. Physical neglect significantly predicts higher z-unit weighted composite scores of LOOH+SOD, LOOH+SOD+NOx, LOOH+SOD+NOx + MDA and LOOH+SOD+NOx + AOPP. Sexual abuse was associated with a significantly lower composite s core of zinc+albumin+SH. Emotio nal abuse was associated with severity of depression and anxiety, number of depressive and mani c episodes, alcohol and hypnotics use, lifetime suicidal behavior and lowered quality of life. Sexual abuse was associated with an increased risk towards BD, but not MDD. ELT, especially physical neglect, may drive increased (nitro-)oxidativ e stress coupled with lipid and protein oxida tion, which - together with emotional abuse - may play a role in severity of illness, lowered quality of life and MDD. ELTs are also associated with the onset of BD, but this link did not appear to be related to activated O&NS pathways. These novel findings deserve confirma tion in prospective studies.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-30T14:06:09Z
2018-05-30T14:06:09Z
2018-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv MORAES, J. B. et al. In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life. Metabolic Brain Disease, New York, p. 1-16, mar. 2018.
0885-7490
1573-7365 (On-line)
http://www.repositorio.ufc.br/handle/riufc/32418
identifier_str_mv MORAES, J. B. et al. In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life. Metabolic Brain Disease, New York, p. 1-16, mar. 2018.
0885-7490
1573-7365 (On-line)
url http://www.repositorio.ufc.br/handle/riufc/32418
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Metabolic Brain Disease
publisher.none.fl_str_mv Metabolic Brain Disease
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1813029046320103424