Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)

Detalhes bibliográficos
Autor(a) principal: da Cruz, Danielle Coelho
Data de Publicação: 2022
Outros Autores: Severo Menezes, Antônio Carlos, Sabbag Cunha, Gracielle Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Brasiliensis (Online)
Texto Completo: http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/621
Resumo: The objective of this research was to perform a preliminary phytochemical study and investigate the toxicity, cytotoxicity and antibacterial activity of the species Tibouchina papyrus (Melastomataceae). The toxicity test was performed with the extracts against Artemia salina. The cytotoxic study was also performed against the following cell lines: promyelocytic leukemia (HL60), human colon carcinoma (HCT-116), breast carcinoma (MCF-7), prostate carcinoma (PC3), astrocytoma (SNB-19) and non-tumor cells (L929). Last, antibacterial activity was assessed through against Staphylococcus epidermidis (25923), Staphylococcus aureus (12228), Escherichia coli (25312) and Pseudomonas aeruginosa (27853). The phytochemical investigation indicated the presence of these metabolite groups: flavonoids, triterpenes, steroids and tannins. The methanolic extracts showed moderate antibacterial activity against S. aureus, S. epidermidis and P. aeruginosa. T. papyrus extracts showed high cytotoxic activity against promyelocytic leukemia cell lines (80.43 to 93.31%). The other lines did not reveal good activity against the extracts tested.
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spelling Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae) Avaliação da toxicidade, citotoxicidade e atividade antibacteriana de Tibouchina papyrus (Pohl) Toledo (Melastomataceae)The objective of this research was to perform a preliminary phytochemical study and investigate the toxicity, cytotoxicity and antibacterial activity of the species Tibouchina papyrus (Melastomataceae). The toxicity test was performed with the extracts against Artemia salina. The cytotoxic study was also performed against the following cell lines: promyelocytic leukemia (HL60), human colon carcinoma (HCT-116), breast carcinoma (MCF-7), prostate carcinoma (PC3), astrocytoma (SNB-19) and non-tumor cells (L929). Last, antibacterial activity was assessed through against Staphylococcus epidermidis (25923), Staphylococcus aureus (12228), Escherichia coli (25312) and Pseudomonas aeruginosa (27853). The phytochemical investigation indicated the presence of these metabolite groups: flavonoids, triterpenes, steroids and tannins. The methanolic extracts showed moderate antibacterial activity against S. aureus, S. epidermidis and P. aeruginosa. T. papyrus extracts showed high cytotoxic activity against promyelocytic leukemia cell lines (80.43 to 93.31%). The other lines did not reveal good activity against the extracts tested.O objetivo dessa pesquisa foi realizar triagem fitoquímica e investigar a toxicidade, citotoxicidade e atividade antibacteriana da espécie Tibouchina papyrus (Melastomataceae). A toxicidade foi realizada realizado com os extratos frente à Artemia salina. O estudo citotóxico também foi realizado, frente às seguintes linhagens celulares: leucemia promielocítica (HL60), carcinoma de cólon humano (HCT-116), carcinoma de mama (MCF-7), carcinoma de próstata (PC3), astrocitoma (SNB-19) e células não tumorais (L929). Por fim, foi analisada a atividade antibacteriana frente às bactérias Staphylococcus epidermidis (25923), Staphylococcus aureus (12228), Escherichia coli (25312) e Pseudomonas aeruginosa (27853). A investigação fitoquímica indicou presença dos grupos metabólitos: flavonoides, triterpenos, esteroides e taninos. Os extratos metanólicos  apresentaram atividade antibacteriana moderada frente à S. aureus, S. epidermidis e P. aeruginosa. Os extratos de T. papyrus apresentaram alta atividade citotóxica frente a linhagem de leucemia promielocítica 80,43 a 93,31%. As demais linhagens não apresentaram boa atividade frente aos extratos testados.Universidade Federal de Campina Grande - UFCG2022-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/62110.22571/2526-4338621Acta Brasiliensis; Vol 6 No 3 (2022): Acta Brasiliensis; 84-88Acta Brasiliensis; Vol 6 No 3 (2022): Acta Brasiliensis; 84-88Acta Brasiliensis; Vol 6 No 3 (2022): Acta Brasiliensis; 84-882526-43382526-432Xreponame:Acta Brasiliensis (Online)instname:Universidade Federal de Campina Grande (UFCG)instacron:UFCGenghttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/621/151Copyright (c) 2022 Acta Brasiliensisinfo:eu-repo/semantics/openAccessda Cruz, Danielle CoelhoSevero Menezes, Antônio CarlosSabbag Cunha, Gracielle Oliveira2022-09-30T22:13:56Zoai:ActaBra.revistas.ufcg.edu.br:article/621Revistahttp://revistas.ufcg.edu.br/ActaBraPUBhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/oaiactabrasiliensis@gmail.com || actabrasiliensis@gmail.com2526-432X2526-4338opendoar:2022-09-30T22:13:56Acta Brasiliensis (Online) - Universidade Federal de Campina Grande (UFCG)false
dc.title.none.fl_str_mv Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)

Avaliação da toxicidade, citotoxicidade e atividade antibacteriana de Tibouchina papyrus (Pohl) Toledo (Melastomataceae)
title Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)
spellingShingle Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)
da Cruz, Danielle Coelho
title_short Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)
title_full Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)
title_fullStr Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)
title_full_unstemmed Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)
title_sort Evaluation of the toxicity, cytotoxicity and antibacterial activity of Tibouchina papyrus (Pohl) Toledo (Melastomataceae)
author da Cruz, Danielle Coelho
author_facet da Cruz, Danielle Coelho
Severo Menezes, Antônio Carlos
Sabbag Cunha, Gracielle Oliveira
author_role author
author2 Severo Menezes, Antônio Carlos
Sabbag Cunha, Gracielle Oliveira
author2_role author
author
dc.contributor.author.fl_str_mv da Cruz, Danielle Coelho
Severo Menezes, Antônio Carlos
Sabbag Cunha, Gracielle Oliveira
description The objective of this research was to perform a preliminary phytochemical study and investigate the toxicity, cytotoxicity and antibacterial activity of the species Tibouchina papyrus (Melastomataceae). The toxicity test was performed with the extracts against Artemia salina. The cytotoxic study was also performed against the following cell lines: promyelocytic leukemia (HL60), human colon carcinoma (HCT-116), breast carcinoma (MCF-7), prostate carcinoma (PC3), astrocytoma (SNB-19) and non-tumor cells (L929). Last, antibacterial activity was assessed through against Staphylococcus epidermidis (25923), Staphylococcus aureus (12228), Escherichia coli (25312) and Pseudomonas aeruginosa (27853). The phytochemical investigation indicated the presence of these metabolite groups: flavonoids, triterpenes, steroids and tannins. The methanolic extracts showed moderate antibacterial activity against S. aureus, S. epidermidis and P. aeruginosa. T. papyrus extracts showed high cytotoxic activity against promyelocytic leukemia cell lines (80.43 to 93.31%). The other lines did not reveal good activity against the extracts tested.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/621
10.22571/2526-4338621
url http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/621
identifier_str_mv 10.22571/2526-4338621
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/621/151
dc.rights.driver.fl_str_mv Copyright (c) 2022 Acta Brasiliensis
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Acta Brasiliensis
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Campina Grande - UFCG
publisher.none.fl_str_mv Universidade Federal de Campina Grande - UFCG
dc.source.none.fl_str_mv Acta Brasiliensis; Vol 6 No 3 (2022): Acta Brasiliensis; 84-88
Acta Brasiliensis; Vol 6 No 3 (2022): Acta Brasiliensis; 84-88
Acta Brasiliensis; Vol 6 No 3 (2022): Acta Brasiliensis; 84-88
2526-4338
2526-432X
reponame:Acta Brasiliensis (Online)
instname:Universidade Federal de Campina Grande (UFCG)
instacron:UFCG
instname_str Universidade Federal de Campina Grande (UFCG)
instacron_str UFCG
institution UFCG
reponame_str Acta Brasiliensis (Online)
collection Acta Brasiliensis (Online)
repository.name.fl_str_mv Acta Brasiliensis (Online) - Universidade Federal de Campina Grande (UFCG)
repository.mail.fl_str_mv actabrasiliensis@gmail.com || actabrasiliensis@gmail.com
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